Results 11 to 20 of about 9,905,544 (245)
Repurposing Interleukin-6 Inhibitors to Combat COVID-19. [PDF]
, 2020 Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) is a pandemic with major implications across the world. One of the most frequent causes of death from SARS-CoV-2 is fatal pneumonia from coronavirus disease 2019 (COVID-19), which is associated
Kato, Shumei, Kurzrock, Razelle
core +1 more source
Autoimmunity Reviews, 2020 Severe COVID-19 associated pneumonia patients may exhibit features of systemic hyper-inflammation designated under the umbrella term of macrophage activation syndrome (MAS) or cytokine storm, also known as secondary haemophagocytic lymphohistocytosis ...
D. McGonagle +3 more
semanticscholar +1 more source
Interleukin-6: obstacles to targeting a complex cytokine in critical illness
The Lancet Respiratory Medicine, 2021 Circulating concentrations of the pleiotropic cytokine interleukin-6 (IL-6) are known to be increased in pro-inflammatory critical care syndromes, such as sepsis and acute respiratory distress syndrome. Elevations in serum IL-6 concentrations in patients
O. McElvaney +3 more
semanticscholar +1 more source
Phenotypic features of interleukin-6 gene polymorphism in the context of formation of addictive pathology [PDF]
, 1998 Search for biomarkers of addictive disorders including molecular-genetic and immunoregulatory characteristics is of relevance. 114 persons with mental and behavioural disorders caused by use of psychoactive substances and 97 conditionally healthy persons
Brokmeier, Heinz-Günter +2 more
core +2 more sources
Interleukin-6: A Novel Target for Cardio-Cerebrovascular Diseases
Frontiers in Pharmacology, 2021 Cardio-Cerebrovascular Disease is a collective term for cardiovascular disease and cerebrovascular disease, being a serious threat to human health. A growing number of studies have proved that the content of inflammatory factors or mediators determines ...
Jiangping Su +7 more
semanticscholar +1 more source
Annals of the Rheumatic Diseases, 2012 Background Since approval of tocilizumab (TCZ) for treatment of rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA), interleukin 6 (IL-6) pathway inhibition was evaluated in trials of TCZ and other agents targeting the IL-6 receptor and ...
Josef S Smolen +34 more
semanticscholar +1 more source
Paraneoplastic thrombocytosis in ovarian cancer [PDF]
, 2012 <p>Background: The mechanisms of paraneoplastic thrombocytosis in ovarian cancer and the role that platelets play in abetting cancer growth are unclear.</p> <p>Methods: We analyzed clinical data on 619 patients with epithelial ...
Akl EA +35 more
core +1 more source
Interleukin‐6 in Covid‐19: A systematic review and meta‐analysis
medRxiv, 2020 Coronaviruses may activate dysregulated host immune responses. As exploratory studies have suggested that interleukin‐6 (IL‐6) levels are elevated in cases of complicated Covid‐19, we undertook a systematic review and meta‐analysis to assess the evidence
E. Coomes, H. Haghbayan
semanticscholar +1 more source
Journal of Autoimmunity, 2020 The emergent outbreak of coronavirus disease 2019 (COVID-19) has caused a global pandemic. Acute respiratory distress syndrome (ARDS) and multiorgan dysfunction are among the leading causes of death in critically ill patients with COVID-19.
Bingwen Liu +4 more
semanticscholar +1 more source
Placental-mediated increased cytokine response to lipopolysaccharides: a potential mechanism for enhanced inflammation susceptibility of the preterm fetus. [PDF]
, 2012 BackgroundCerebral palsy is a nonprogressive motor impairment syndrome that has no effective cure. The etiology of most cases of cerebral palsy remains unknown; however, recent epidemiologic data have demonstrated an association between fetal neurologic ...
Belkacemi, Louiza +4 more
core +1 more source