Results 61 to 70 of about 6,778,674 (329)
D-mannose suppresses macrophage IL-1β production
Nature Communications, 2020 D-mannose is a monosaccharide approximately a hundred times less abundant than glucose in human blood. Previous studies demonstrated that supraphysiological levels of D-mannose inhibit tumour growth and stimulate regulatory T cell differentiation.
S. Torretta +9 more
semanticscholar +1 more source
A critical role for hemolysin in Vibrio fluvialis-induced IL-1β secretion mediated by the NLRP3 inflammasome in macrophages [PDF]
Frontiers in Microbiology, 2015 Vibrio fluvialis causes human diarrhea, but the pathogenesis is not well-studied. We hypothesized that V. fluvialis-secreted hemolysin (VFH) may induce IL-1β secretion through the activation of the NLRP3 inflammasome and contribute to the pathogenicity of V. fluvialis.
Song, Liqiong +9 more
openaire +3 more sources
, 2016 (A) Gene expression profiling identified Mmp7 as one of the top up-regulated gene in Asc-/- and Nlrp3-/- mice with bladder pathology (CFT073 infected mice, 7 days). Log2 fold change of Mmp7 expression levels in individual mice are shown relative to the H&
Björn Wullt (243099) +10 more
core +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Shwachman–Diamond syndrome (SDS) is a rare autosomal recessive ribosomopathy characterized by bone marrow failure and multisystem involvement, with emerging evidence of associated neurocognitive impairment. Methods We conducted a retrospective study of 240 individuals with biallelic Shwachman–Bodian–Diamond syndrome (SBDS) mutations
Jane Koo +11 more
wiley +1 more source
Non-canonical Inflammasome-Mediated IL-1β Production by Primary Endometrial Epithelial and Stromal Fibroblast Cells Is NLRP3 and Caspase-4 Dependent [PDF]
Frontiers in Immunology, 2019 Inflammation of the post-partum uterus is a normal physiological event, crucial for tissue involution and repair. However, in the bovine, some cows fail to resolve this inflammation, resulting in endometritis, which compromises fertility. Earlier work has identified upregulated expression of the potent inflammatory cytokine IL-1β early post-partum, in ...
Paul Kelly +4 more
openaire +6 more sources
HPV16 oncoproteins inhibit pro-IL-1β levels.
, 2018 (A) Human keratinocytes transduced with pLXSN or 16E6E7 were stimulated with AIM2 and (B) NLPR3 ligands and both pro-IL-1β and IL-1β from cell lysates or supernatants were analysed by immunoblotting. β-actin was used as a loading control.
Claudia Zannetti (199411) +21 more
core +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa +7 more
wiley +1 more source
Serine metabolism supports macrophage IL-1β production.
Cell Metabolism, 2019 SUMMARY Serine is a substrate for nucleotides, NADPH and glutathione (GSH) synthesis. Previous studies in cancer cells and lymphocytes have shown that serine-dependent one-carbon units are necessary for nucleotide production to support proliferation ...
Arianne E. Rodriguez +10 more
semanticscholar +1 more source
ATP-Induced IL-1β Specific Secretion: True Under Stringent Conditions [PDF]
Frontiers in Immunology, 2015 Interleukin-1β is a potent proinflammatory cytokine, of which processing and secretion are tightly regulated. After exposure to various stimuli, mononuclear phagocytes synthesize the inactive precursor (pro-IL-1β), which is then cleaved intracellularly by caspase-1 and secreted.
Monique eStoffels +11 more
openaire +5 more sources
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source