Results 61 to 70 of about 375,754 (237)

Brain Perivascular Macrophages Do Not Mediate Interleukin-1-Induced Sickness Behavior in Rats

Pharmaceuticals, 2021
Sickness behavior, characterized by on overall reduction in behavioral activity, is commonly observed after bacterial infection. Sickness behavior can also be induced by the peripheral administration of Gram-negative bacterial lipopolysaccharide (LPS) or
Léa Chaskiel, Robert Dantzer, Jan Pieter Konsman   +2 more
doaj   +1 more source

Glibenclamide inhibits NLRP3 inflammasome-mediated IL-1β secretion in human trophoblasts

Journal of Pharmacological Sciences, 2017
Infection-associated pregnancy complications cause premature delivery. Caspase-1 is involved in the maturation of interleukin (IL)-1β, which is activated by the NLRP3 inflammasome. To characterize the significance of the NLRP3 inflammasome pathway in the placenta, the effects of activators and inhibitors on NLRP3-related molecules were examined using ...
Kazuhiro Tamura, Gen Ishikawa, Mikihiro Yoshie, Wakana Ohneda, Akihito Nakai, Toshiyuki Takeshita, Eiichi Tachikawa   +6 more
openaire   +3 more sources

Secretory Phospholipase A2 in Patients With Sickle Cell Disease Hospitalized for Vaso‐Occlusive Pain Episodes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Secretory phospholipase A2 (sPLA2) is an inflammatory mediator linked to acute chest syndrome (ACS) in sickle cell disease (SCD), a serious complication that can develop during an acute vaso‐occlusive pain episode (VOE). Plasma sPLA2 levels have been proposed as a potential biomarker for predicting ACS onset.
Rawan Korman, Maria Yasmine, Dunia Hatabah, Noor Alzraikat, Frank Harris, Lou Ann Brown, Satheesh Chonat, Nitya Bakshi, Chris A. Rees, Carlton Dampier, Claudia R. Morris   +10 more
wiley   +1 more source

La interleucina-1β aumenta la muerte neuronal en el giro dentado del hipocampo asociada al estado epiléptico en la rata en desarrollo

Neurología, 2017
Resumen: Introducción: La interleucina 1β (IL-1β) aumenta la muerte neuronal necrótica debido al estado epiléptico (EE) en el área CA1 del hipocampo de ratas en desarrollo; sin embargo, se desconoce si ejerce un efecto similar en el giro dentado (GD ...
C. Rincón-López, A. Tlapa-Pale, J.-S. Medel-Matus, J. Martínez-Quiroz, J.F. Rodríguez-Landa, M.-L. López-Meraz   +5 more
doaj   +1 more source

Alteration of dopamine, homovanillic acid (HVA) with interleukine-1β (IL-1β) and tumor necrosis factor-α (TNF-α) in cerebral palsy

Biodiversitas Journal of Biological Diversity, 1970
Now, diagnosis of cerebral palsy base only on clinical finding without involve the alteration of the neurochemistry cause by cerebral hypoxic, although cerebral palsy is a syndrome cause by cerebral hypoxic; so, the accuracy diagnosis of this disease is very low.
openaire   +2 more sources

Additional file 2: Table S1. of IL-1β mediates lung neutrophilia and IL-33 expression in a mouse model of viral-induced asthma exacerbation

, 2018
Commercially available primer sequences for genes analysed with RT-qPCR. (DOCX 13 kb)
Mahmutovic Persson, Irma, Menzel, Mandy, Ramu, Sangeetha, Cerps, Samuel, Akbarshahi, Hamid, Uller, Lena   +5 more
openaire   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Additional file 1: Figure S1. of Human iPSC-derived chondrocytes mimic juvenile chondrocyte function for the dual advantage of increased proliferation and resistance to IL-1β

, 2017
Global gene expression patterns in hiChondrocytes and juvenile chondrocytes are distinct from adult chondrocytes: (a) scheme for a step-wise hiChondrocyte differentiation from hiPSC using defined growth factors, (b) cell proliferation kinetics of hiChondrocytes, adult chondrocytes, and juvenile chondrocytes over 24, 48, and 96 hours, (c)heatmap ...
Lee, Jieun, Smeriglio, Piera, Chu, Constance, Bhutani, Nidhi   +3 more
openaire   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

A moonlighting function of tumoral interleukin-1β precursor promotes metastasis via RACK1-mediated actin remodeling

Nature Communications
Interleukin-1β (IL-1β) is a key inflammatory mediator in cancer. Its precursor, Pro-IL-1β, is conventionally considered inactive. Here we demonstrate that head and neck squamous cell carcinoma (HNSCC) cells exhibit significantly elevated Pro-IL-1β ...
Quanzhu Chen, Pan Wu, Jing Cai, Xingxing Lu, Zhaojian Gong, Pan Chen, Zhaoyang Zeng, Guiyuan Li, Wei Xiong, Mei Yi, Bo Xiang   +10 more
doaj   +1 more source