IL-1β and IL-8 secretion in 16HBE cells.
, 2016 Cells in mono- (MO) or co-culture (CO) were incubated for 18h with either liposomes (LIPO), virosomes (VIRO) or controls (PBS, as shown). Supernatants were collected to perform IL-1β and IL-8 ELISA.
Kristína Krempaská (3185868) +9 more
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Double-walled carbon nanotubes trigger IL-1β release in human monocytes through Nlrp3 inflammasome activation [PDF]
, 2012 Because of their outstanding physical properties, carbon nanotubes (CNTs) are promising new materials in the field of nanotechnology. It is therefore imperative to assess their adverse effects on human health.
Dardenne, Christophe +19 more
core +1 more source
IL-1β mRNA expression is elevated in HG mixed glia.
, 2022 The mRNA levels of IL-1β, IL-6, and TNF α in NG and HG mixed glia cultures were quantified by real-time RT PCR. NG, 5.5 mM glucose-containing media; HG, 25 mM glucose-containing media. Data is expressed as mean ± SEM.
Meng An Chien (11993873) +9 more
core +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Lesió i protecció de les cèl·lules beta en el trasplantament d'illots pancreàtics [PDF]
, 2007 [cat] El trasplantament d'illots pancreàtics pot ser una bona teràpia per els malalts amb diabetis mellitus de tipus 1, però hi ha alguns problemes que cal solventar abans que sigui un tractament estès.
Montolio Rusiñol, Marta
core
IL-1β induced a decrease in TER values.
, 2016 In cells treated with 10% FBS (open circles) and 2% FBS in the presence (closed circles) or absence (closed squares) of IL-1β (50 pM) for the indicated time periods, the barrier properties were monitored by measuring TER.
Taku Kitanaka (3350276) +9 more
core +1 more source
Octacalcium phosphate crystals directly stimulate expression of inducible nitric oxide synthase through p38 and JNK mitogen-activated protein kinases in articular chondrocytes [PDF]
, 2005 Basic calcium phosphate (BCP) crystals, including hydroxyapatite, octacalcium phosphate (OCP) and carbonate-apatite, have been associated with severe osteoarthritis and several degenerative arthropathies.
Uzan, Benjamin +3 more
core +1 more source
PLoS ONE, 2013 BackgroundMultiple sclerosis (MS) has been mainly attributed to white matter (WM) pathology. However, recent evidence indicated the presence of grey matter (GM) lesions.
Marloes Prins +6 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source