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Pyroptosis: mechanisms and diseases [PDF]

Signal Transduction and Targeted Therapy, 2021
Currently, pyroptosis has received more and more attention because of its association with innate immunity and disease. The research scope of pyroptosis has expanded with the discovery of the gasdermin family.
Pian Yu, Xu Zhang, Nian Liu, Ling Tang, Cong Peng, Xiang Chen   +5 more
doaj   +3 more sources

Approaching Neutrophil Pyroptosis [PDF]

Journal of Molecular Biology, 2022
All cells must die at some point, and the dogma is that they do it either silently via apoptosis or via pro-inflammatory, lytic forms of death. Amongst these lytic cell death pathways, pyroptosis is one of the best characterized.
Sollberger, G., Sollberger, Gabriel
core   +5 more sources

Pyroptosis in Periprosthetic Osteolysis

Biomolecules, 2022
Periprosthetic osteolysis (PPO) along with aseptic loosening (AL) caused by wear particles after artificial joint replacement is the key factor in surgical failure and subsequent revision surgery, however, the precise molecular mechanism underlying PPO ...
Yin, Jian, Peng Lai, Jian Yin, Ma, Jinzhong, Yin, Zhaoyang, Liu, Xinhui, Jinzhong Ma, Lai, Peng, Zhaoyang Yin, Xinhui Liu   +9 more
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Pyroptosis in Pulpitis

Journal of Inflammation Research
Xiaorui Wei,1 Shidian Ran,1 Xingrui Yan,1 Jindie Huang,1 Linyu Xue,1 Tong-Chuan He,2,3 Hongmei Zhang,1 Si Wu1 1The Affiliated Stomatological Hospital of Chongqing Medical University, Chongqing Key Laboratory of Oral Diseases, Chongqing Municipal Key ...
Ran S, Huang J, He TC, Zhang H, Wu S, Wei X, Xue L, Yan X   +7 more
core   +6 more sources

Pyroptosis in pterygium pathogenesis [PDF]

Bioscience Reports, 2018
Pterygium is a common ocular disease characterized by proliferating fibrovascular tissue. Pyroptosis, a recently discovered programed cell death, is known to be associated with oxidative stress, one of the main causes of pterygia. Here, we aimed to study
Naiyu Sun, Hong Zhang
core   +3 more sources

Bioorthogonal Disruption of Pyroptosis Checkpoint for High-Efficiency Pyroptosis Cancer Therapy

Journal of the American Chemical Society, 2023
Pyroptosis is an inflammatory form of programmed cell death that holds great promise in cancer therapy. However, autophagy as the crucial pyroptosis checkpoint and the self-protective mechanism of cancer cells significantly weakens the therapeutic ...
Xiaogang Qu, Wenting Zhang, Jinsong Ren (260913), Yu Zhang, Zhenqi Liu (296064), Zhenqi Liu, Zhengwei Liu (3452954), Zhengwei Liu, Jinsong Ren, Jiawei Zhu, Geng Qin, Xiaogang Qu (19674), Wenting Zhang (342162), Yu Zhang (12946), Geng Qin (567797), Jiawei Zhu (177754)   +15 more
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Harnessing Pyroptosis for Cancer Immunotherapy

Cells
Cancer immunotherapy is a novel pillar of cancer treatment that harnesses the immune system to fight tumors and generally results in robust antitumor immunity.
Christopher M. Bourne, Cornelius Y. Taabazuing   +1 more
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Emerging Mechanisms and Targeted Therapy of Pyroptosis in Central Nervous System Trauma

Frontiers in Cell and Developmental Biology, 2022
Cell death can occur in different modes, ferroptosis, pyroptosis, apoptosis, and necroptosis. Recent studies have shown that pyroptosis can be effectively regulated and that like necroptosis, pyroptosis has been regarded as a type of programmed cell ...
Biao Yang, Biao Yang, Weijie Zhong, Ying Gu, Yi Li   +4 more
doaj   +1 more source

Noncoding RNAs in pyroptosis and cancer progression: Effect, mechanism, and clinical application

Frontiers in Immunology, 2022
Cell death is generally classified into two categories: regulated cell death (RCD) and accidental cell death (ACD). In particular, RCD is a kind of genetically controlled process, including programmed apoptotic death and programmed necrotic death ...
Menghui Zhang, Pengyuan Dang, Yang Liu, Bingbing Qiao, Zhenqiang Sun   +4 more
doaj   +1 more source

Establishment of a novel indicator of pyroptosis regulated gene transcription level and its application in pan-cancer

Scientific Reports, 2023
Pyroptosis is a type of programmed cell death and plays a dual role in distinct cancers. It is elusive to evaluate the activation level of pyroptosis and to appraise the involvement of pyroptosis in the occurrence and development of diverse tumors ...
Jin-Zhou Xu, Qi-Dong Xia, Jian-Xuan Sun, Chen-Qian Liu, Jun-Lin Lu, Meng-Yao Xu, Ye An, Yang Xun, Zheng Liu, Jia Hu, Cong Li, Shao-Gang Wang   +11 more
doaj   +1 more source