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Pyroptosis: mechanisms and diseases [PDF]
Signal Transduction and Targeted Therapy, 2021 Currently, pyroptosis has received more and more attention because of its association with innate immunity and disease. The research scope of pyroptosis has expanded with the discovery of the gasdermin family.
Xu Zhang, Nian Liu, Ling Tang
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Emerging Mechanisms and Targeted Therapy of Pyroptosis in Central Nervous System Trauma
Frontiers in Cell and Developmental Biology, 2022 Cell death can occur in different modes, ferroptosis, pyroptosis, apoptosis, and necroptosis. Recent studies have shown that pyroptosis can be effectively regulated and that like necroptosis, pyroptosis has been regarded as a type of programmed cell ...
Biao Yang +4 more
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Noncoding RNAs in pyroptosis and cancer progression: Effect, mechanism, and clinical application
Frontiers in Immunology, 2022 Cell death is generally classified into two categories: regulated cell death (RCD) and accidental cell death (ACD). In particular, RCD is a kind of genetically controlled process, including programmed apoptotic death and programmed necrotic death ...
Menghui Zhang +4 more
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Scientific Reports, 2023 Pyroptosis is a type of programmed cell death and plays a dual role in distinct cancers. It is elusive to evaluate the activation level of pyroptosis and to appraise the involvement of pyroptosis in the occurrence and development of diverse tumors ...
Jin-Zhou Xu +11 more
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Scientific Reports, 2022 Understanding the association of pyroptosis with tumor progression, prognosis and effect on immunotherapeutic response in breast cancer (BC) is limited. This study analysed forty pyroptosis-related genes to construct the pyroptosis score.
Guo Huang +3 more
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Frontiers in Genetics, 2023 The phenotype of pyroptosis has been extensively studied in a variety of tumors, but the relationship between pyroptosis and esophageal squamous cell carcinoma (ESCC) remains unclear. Here, 22 pyroptosis genes were downloaded from the website of Gene Set
Zhan-Fei Zhang, Zhan-Fei Zhang
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Journal of Translational Medicine, 2022 Background Programmed cell death is an active and orderly form of cell death regulated by intracellular genes that plays an important role in the normal occurrence and development of the immune system, and pyroptosis has been found to be involved in ...
Aibin Liu +4 more
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NLRP3 inflammasome-induced pyroptosis in digestive system tumors
Frontiers in Immunology, 2023 Programmed cell death (PCD) refers to cell death in a manner that depends on specific genes encoding signals or activities. PCD includes apoptosis, pyroptosis, autophagy and necrosis (programmed necrosis).
Jiexia Wen +8 more
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Methods for monitoring cancer cell pyroptosis
Cancer Biology & Medicine, 2022 Pyroptosis is a form of proinflammatory cell death that depends on the gasdermin family of proteins. The main features of pyroptosis are altered membrane permeability, cell swelling, membrane rupture, and the ability to mobilize a strong immune response.
Shuo Wang +3 more
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Emerging mechanisms of pyroptosis and its therapeutic strategy in cancer
Cell Death Discovery, 2022 Pyroptosis, a type of inflammatory programmed cell death, is triggered by caspase cleavage of gasdermin family proteins. Based on accumulating evidence, pyroptosis is closely associated with tumour development, but the molecular mechanism underlying ...
Liqing Lu +12 more
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