Results 11 to 20 of about 6,483 (210)

Harnessing Pyroptosis for Cancer Immunotherapy

Cells
Cancer immunotherapy is a novel pillar of cancer treatment that harnesses the immune system to fight tumors and generally results in robust antitumor immunity.
Christopher M. Bourne, Cornelius Y. Taabazuing   +1 more
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Pyroptosis [PDF]

Current Biology, 2016
Injury and physical trauma may inflict accidental cell death, but we have come to realize during the past four decades that cells may also actively engage cell death when needed. These regulated cell death forms are intrinsically connected with human embryonic development, homeostatic maintenance and disease pathology.
Lieselotte, Vande Walle, Mohamed, Lamkanfi   +1 more
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Pyroptosis in Kidney Disease

Journal of Molecular Biology, 2022
In the last several decades, apoptosis interference has been considered clinically irrelevant in the context of renal injury. Recent discovery of programmed necrotic cell death, including necroptosis, ferroptosis, and pyroptosis refreshed our understanding of the role of cell death in kidney disease.
Yujia, Wang, Yinshuang, Li, Yanfang, Xu
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Genomic Analysis Uncovers the Prognostic and Immunogenetic Feature of Pyroptosis in Gastric Carcinoma: Indication for Immunotherapy

Frontiers in Cell and Developmental Biology, 2022
Crosstalk between pyroptosis and tumor immune microenvironment (TIME) in cancer has yet to be elucidated. Herein, we aimed to explore the role of pyroptosis and its association with TIME in gastric cancer.
Jie Zhou, Run-cong Nie, Run-cong Nie, Yi-xin Yin, Yun Wang, Yun Wang, Shu-qiang Yuan, Shu-qiang Yuan, Zi-han Zhao, Zi-han Zhao, Xin-ke Zhang, Xin-ke Zhang, Jin-ling Duan, Jin-ling Duan, Ying-bo Chen, Ying-bo Chen, Zhi-wei Zhou, Zhi-wei Zhou, Dan Xie, Dan Xie, Yuan-fang Li, Yuan-fang Li, Mu-yan Cai, Mu-yan Cai   +23 more
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Inhibition of macrophage pyroptosis ameliorates silica-induced pulmonary fibrosis

Ecotoxicology and Environmental Safety, 2023
Macrophage pyroptosis has recently been involved in some inflammatory and fibrosis diseases, however, the role of macrophage pyroptosis in silica-induced pulmonary fibrosis has not been fully elucidated.
Fuyang Jiang, Qiyue Jiang, Lin Hou, Jing Zhao, Zhonghui Zhu, Qiyue Jia, Wenming Xue, Hongwei Wang, Yan Wang, Lin Tian   +9 more
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Induction of Pyroptosis: A Promising Strategy for Cancer Treatment

Frontiers in Oncology, 2021
Pyroptosis, a lytic pro-inflammatory type of programmed cell death, has been widely studied in diverse inflammatory disease models. Membrane perforation and cell swelling induced by cleaved gasdermin family members is the main characteristic of ...
Lei Wang, Xiaowei Qin, Jianmin Liang, Pengfei Ge   +3 more
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Complement induces podocyte pyroptosis in membranous nephropathy by mediating mitochondrial dysfunction

Cell Death and Disease, 2022
Podocyte damage mediated by in situ complement activation in the glomeruli is a key factor in the pathogenesis of membranous nephropathy (MN), but the molecular mechanism has not been fully elucidated.
Hui Wang, Daoyuan Lv, Song Jiang, Qing Hou, Lei Zhang, Shen Li, Xiaodong Zhu, Xiaodong Xu, Jianqiang Wen, Caihong Zeng, Mingchao Zhang, Fan Yang, Zhaohong Chen, Chunxia Zheng, Jing Li, Ke Zen, Zhihong Liu, Limin Li   +17 more
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Establishment of a prognosis Prediction Model Based on Pyroptosis-Related Signatures Associated With the Immune Microenvironment and Molecular Heterogeneity in Clear Cell Renal Cell Carcinoma

Frontiers in Oncology, 2021
BackgroundPyroptosis is essential for tumorigenesis and progression of neoplasm. However, the heterogeneity of pyroptosis and its relationship with the tumor microenvironment (TME) in clear cell renal cell carcinoma (ccRCC) remain unclear. The purpose of
Aimin Jiang, Jialin Meng, Yewei Bao, Anbang Wang, Wenliang Gong, Xinxin Gan, Jie Wang, Yi Bao, Zhenjie Wu, Juan Lu, Bing Liu, Linhui Wang   +11 more
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The implication of pyroptosis in cancer immunology: Current advances and prospects

Genes and Diseases, 2023
Pyroptosis is a regulated cell death pathway involved in numerous human diseases, especially malignant tumors. Recent studies have identified multiple pyroptosis-associated signaling molecules, like caspases, gasdermin family and inflammasomes.
Wei Liu, Jinwu Peng, Muzhang Xiao, Yuan Cai, Bi Peng, Wenqin Zhang, Jianbo Li, Fanhua Kang, Qianhui Hong, Qiuju Liang, Yuanliang Yan, Zhijie Xu   +11 more
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Pyroptosis in pterygium pathogenesis [PDF]

Bioscience Reports, 2018
Pterygium is a common ocular disease characterized by proliferating fibrovascular tissue. Pyroptosis, a recently discovered programed cell death, is known to be associated with oxidative stress, one of the main causes of pterygia. Here, we aimed to study the role of pyroptosis in pterygium pathogenesis.
Sun, Naiyu, Zhang, Hong
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