Results 21 to 30 of about 63,199 (297)
IFI27 and BAX are Essential for GSDME-Mediated Myeloma Cell Pyroptosis. [PDF]
Adv Sci (Weinh)The proposed model of GSDME‐mediated MM cell pyroptosis modulated by IFI27 and BAX. IFI27 is downregulated in MM cells. Upon pyroptotic stimulation, such as DOX or ETO treatment, IFI27 is induced, therefore liberating BAX from BCL‐2 ❶. BAX is then recruited to mitochondria and forms homo‐oligomeric channels in OMM, therefore leading to cytochrome C ...
Cui Y +12 more
europepmc +2 more sources
Role of pyroptosis in COVID-19 [PDF]
, 2023 Aim: In this study, we aimed to investigate the relationship between gasdermin-D, caspase-1, IL-1β and NLRP3, biomarkers that play an important role in COVID-19, and pyroptosis.
Mahmut Alp Karahan +5 more
core +2 more sources
Journal of Molecular Biology, 2022 In the last several decades, apoptosis interference has been considered clinically irrelevant in the context of renal injury. Recent discovery of programmed necrotic cell death, including necroptosis, ferroptosis, and pyroptosis refreshed our understanding of the role of cell death in kidney disease.
Yujia, Wang, Yinshuang, Li, Yanfang, Xu
openaire +2 more sources
Frontiers in Cell and Developmental Biology, 2022 Crosstalk between pyroptosis and tumor immune microenvironment (TIME) in cancer has yet to be elucidated. Herein, we aimed to explore the role of pyroptosis and its association with TIME in gastric cancer.
Jie Zhou +23 more
doaj +1 more source
Inhibition of macrophage pyroptosis ameliorates silica-induced pulmonary fibrosis
Ecotoxicology and Environmental Safety, 2023 Macrophage pyroptosis has recently been involved in some inflammatory and fibrosis diseases, however, the role of macrophage pyroptosis in silica-induced pulmonary fibrosis has not been fully elucidated.
Fuyang Jiang +9 more
doaj +1 more source
Frontiers in Oncology, 2021 BackgroundPyroptosis is essential for tumorigenesis and progression of neoplasm. However, the heterogeneity of pyroptosis and its relationship with the tumor microenvironment (TME) in clear cell renal cell carcinoma (ccRCC) remain unclear. The purpose of
Aimin Jiang +11 more
doaj +1 more source
Cell Death and Disease, 2022 Podocyte damage mediated by in situ complement activation in the glomeruli is a key factor in the pathogenesis of membranous nephropathy (MN), but the molecular mechanism has not been fully elucidated.
Hui Wang +17 more
doaj +1 more source
Induction of Pyroptosis: A Promising Strategy for Cancer Treatment
Frontiers in Oncology, 2021 Pyroptosis, a lytic pro-inflammatory type of programmed cell death, has been widely studied in diverse inflammatory disease models. Membrane perforation and cell swelling induced by cleaved gasdermin family members is the main characteristic of ...
Lei Wang +3 more
doaj +1 more source
Enamel Matrix Derivative Decreases Pyroptosis-Related Genes in Macrophages. [PDF]
, 2022 Background: Pyroptosis is a caspase-dependent catabolic process relevant to periodontal disorders for which inflammation is central to the pathophysiology of the disease.
Cabral da Cruz, Ariadne Cristiane +7 more
core +2 more sources
The implication of pyroptosis in cancer immunology: Current advances and prospects
Genes and Diseases, 2023 Pyroptosis is a regulated cell death pathway involved in numerous human diseases, especially malignant tumors. Recent studies have identified multiple pyroptosis-associated signaling molecules, like caspases, gasdermin family and inflammasomes.
Wei Liu +11 more
doaj +1 more source