Results 21 to 30 of about 47,718 (166)

The Role of Mitochondria in Pyroptosis [PDF]

Frontiers in Cell and Developmental Biology, 2021
Pyroptosis is a recently discovered aspartic aspart-specific cysteine protease (Caspase-1/4/5/11) dependent mode of gene-regulated cell death cell death, which is represented by the rupture of cell membrane perforations and the production of proinflammatory mediaters like interleukin-18(IL-18) and interleukin-1β (IL-1β).
Qian Li, Nengxian Shi, Chen Cai, Mingming Zhang, Jing He, Ying Tan, Weijun Fu   +6 more
openaire   +3 more sources

Aerobic exercise alleviates pyroptosis-related diseases by regulating NLRP3 inflammasome

Frontiers in Physiology, 2022
Pyroptosis plays a crucial role in a variety of human diseases, including atherosclerosis, obesity, diabetes, depression, and Alzheimer’s disease, which usually release pyroptosis-related cytokines due to inflammation. Many studies have demonstrated that
Shujuan Hu, Shujuan Hu, Xingxia Wan, Xianhui Li, Xianwang Wang   +4 more
doaj   +1 more source

Pyroptosis in pterygium pathogenesis [PDF]

Bioscience Reports, 2018
Pterygium is a common ocular disease characterized by proliferating fibrovascular tissue. Pyroptosis, a recently discovered programed cell death, is known to be associated with oxidative stress, one of the main causes of pterygia. Here, we aimed to study the role of pyroptosis in pterygium pathogenesis.
Sun, Naiyu, Zhang, Hong
openaire   +2 more sources

Pyroptosis Regulators and Tumor Microenvironment Infiltration Characterization in Clear Cell Renal Cell Carcinoma

Frontiers in Oncology, 2022
BackgroundIt is well known that chronic inflammation can promote the occurrence and progression of cancer. As a type of proinflammatory death, pyroptosis can recast a suitable microenvironment to promote tumor growth.
Xi Zhang, Xiyi Wei, Yichun Wang, Shuai Wang, Chengjian Ji, Liangyu Yao, Ninghong Song, Ninghong Song   +7 more
doaj   +1 more source

Mesenchymal stem cells protect against TBI-induced pyroptosis in vivo and in vitro through TSG-6

Cell Communication and Signaling, 2022
Background Pyroptosis, especially microglial pyroptosis, may play an important role in central nervous system pathologies, including traumatic brain injury (TBI). Transplantation of mesenchymal stem cells (MSCs), such as human umbilical cord MSCs (hUMSCs)
Zhiming Feng, Shiting Hua, Wangan Li, Jianbang Han, Feng Li, Haijia Chen, Zhongfei Zhang, Yu Xie, Qian Ouyang, Xiaoxiong Zou, Zhizheng Liu, Cong Li, Sixian Huang, Zelin Lai, Xiaolin Cai, Yingqian Cai, Yuxi Zou, Yanping Tang, Xiaodan Jiang   +18 more
doaj   +1 more source

The role of pyroptosis and its crosstalk with immune therapy in breast cancer

Frontiers in Immunology, 2022
Pyroptosis is a brand-new category of programmed cell death (PCD) that is brought on by multitudinous inflammasomes, which can recognize several stimuli to pilot the cleavage of and activate inflammatory cytokines like IL-18 and IL-1β is believed to have
Ling Wu, Ling Wu, Hongsheng Lu, Yin Pan, Chen Liu, Jinyan Wang, Baofu Chen, Yichao Wang   +7 more
doaj   +1 more source

Approaching Neutrophil Pyroptosis

Journal of Molecular Biology, 2022
All cells must die at some point, and the dogma is that they do it either silently via apoptosis or via pro-inflammatory, lytic forms of death. Amongst these lytic cell death pathways, pyroptosis is one of the best characterized. Pyroptosis depends on inflammatory caspases which activate members of the gasdermin family of proteins, and it is associated
openaire   +4 more sources

Pyroptosis Induction and Detection [PDF]

Current Protocols in Immunology, 2018
AbstractPyroptosis is a form of programmed pro‐inflammatory cell death that plays a protective role in the host response to infection, but can also promote pathogenic inflammation. Pyroptosis is mediated by the cysteine protease, caspase‐1. Caspase‐1 cleaves gasdermin D, releasing the N‐terminal pore‐forming domain, which inserts into the plasma ...
Andreas B, den Hartigh, Susan L, Fink
openaire   +2 more sources

Identification of a pyroptosis‐based model for predicting clinical outcomes from immunotherapy in patients with metastatic melanoma

Cancer Medicine, 2023
Immunotherapy has greatly improved outcomes for patients with advanced melanoma, but good predictive biomarkers remain lacking in clinical practice. Although increasing evidence has revealed a vital role of pyroptosis in the tumor microenvironment (TME),
Guanghao Wu, Biying Chen, Junjie Jiang, Yiran Chen, Yanyan Chen, Haiyong Wang   +5 more
doaj   +1 more source

Pyroptosis in Pulpitis

Journal of Inflammation Research
Pulpitis is an inflammatory disease occurs in the pulp tissues. Continuous development of pulpitis can lead to apical periodontitis and seriously damage the function of teeth, affecting the oral health and daily life of patients. Pyroptosis, alternatively termed inflammatory necrosis, is a type of programmed cell death that is characterized by the ...
Wei,Xiaorui, Ran,Shidian, Yan,Xingrui, Huang,Jindie, Xue,Linyu, He,Tong-Chuan, Zhang,Hongmei, Wu,Si   +7 more
openaire   +5 more sources