Results 21 to 30 of about 53,711 (308)
Induction of Pyroptosis: A Promising Strategy for Cancer Treatment
Frontiers in Oncology, 2021 Pyroptosis, a lytic pro-inflammatory type of programmed cell death, has been widely studied in diverse inflammatory disease models. Membrane perforation and cell swelling induced by cleaved gasdermin family members is the main characteristic of ...
Lei Wang +3 more
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Frontiers in Cell and Developmental Biology, 2022 Crosstalk between pyroptosis and tumor immune microenvironment (TIME) in cancer has yet to be elucidated. Herein, we aimed to explore the role of pyroptosis and its association with TIME in gastric cancer.
Jie Zhou +23 more
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Inhibition of macrophage pyroptosis ameliorates silica-induced pulmonary fibrosis
Ecotoxicology and Environmental Safety, 2023 Macrophage pyroptosis has recently been involved in some inflammatory and fibrosis diseases, however, the role of macrophage pyroptosis in silica-induced pulmonary fibrosis has not been fully elucidated.
Fuyang Jiang +9 more
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Frontiers in Oncology, 2021 BackgroundPyroptosis is essential for tumorigenesis and progression of neoplasm. However, the heterogeneity of pyroptosis and its relationship with the tumor microenvironment (TME) in clear cell renal cell carcinoma (ccRCC) remain unclear. The purpose of
Aimin Jiang +11 more
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Cell Death and Disease, 2022 Podocyte damage mediated by in situ complement activation in the glomeruli is a key factor in the pathogenesis of membranous nephropathy (MN), but the molecular mechanism has not been fully elucidated.
Hui Wang +17 more
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The Role of Mitochondria in Pyroptosis [PDF]
Frontiers in Cell and Developmental Biology, 2021 Pyroptosis is a recently discovered aspartic aspart-specific cysteine protease (Caspase-1/4/5/11) dependent mode of gene-regulated cell death cell death, which is represented by the rupture of cell membrane perforations and the production of proinflammatory mediaters like interleukin-18(IL-18) and interleukin-1β (IL-1β).
Qian Li +6 more
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The implication of pyroptosis in cancer immunology: Current advances and prospects
Genes and Diseases, 2023 Pyroptosis is a regulated cell death pathway involved in numerous human diseases, especially malignant tumors. Recent studies have identified multiple pyroptosis-associated signaling molecules, like caspases, gasdermin family and inflammasomes.
Wei Liu +11 more
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Aerobic exercise alleviates pyroptosis-related diseases by regulating NLRP3 inflammasome
Frontiers in Physiology, 2022 Pyroptosis plays a crucial role in a variety of human diseases, including atherosclerosis, obesity, diabetes, depression, and Alzheimer’s disease, which usually release pyroptosis-related cytokines due to inflammation. Many studies have demonstrated that
Shujuan Hu +4 more
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Frontiers in Oncology, 2022 BackgroundIt is well known that chronic inflammation can promote the occurrence and progression of cancer. As a type of proinflammatory death, pyroptosis can recast a suitable microenvironment to promote tumor growth.
Xi Zhang +7 more
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Enamel Matrix Derivative Decreases Pyroptosis-Related Genes in Macrophages. [PDF]
, 2022 Background: Pyroptosis is a caspase-dependent catabolic process relevant to periodontal disorders for which inflammation is central to the pathophysiology of the disease.
Cabral da Cruz, Ariadne Cristiane +7 more
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