Results 1 to 10 of about 21,860 (253)
The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity [PDF]
Cell Reports, 2017 Inflammasomes activate the protease caspase-1, which cleaves interleukin-1β and interleukin-18 to generate the mature cytokines and controls their secretion and a form of inflammatory cell death called pyroptosis.
Katharina S. Schneider +16 more
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The Role of Pyroptosis in Colorectal Cancer: From Mechanisms to Therapeutic Opportunities [PDF]
Cancer Management and ResearchHaiqing Xie, Xueting Deng, Quanpeng Li Medical Center for Digestive Diseases, Second Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of ChinaCorrespondence: Quanpeng Li, Medical Center for Digestive Diseases, Second ...
Xie H, Deng X, Li Q
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The Versatile Gasdermin Family: Their Function and Roles in Diseases
Frontiers in Immunology, 2021 The gasdermin (GSDM) family, a novel group of structure-related proteins, consists of GSDMA, GSDMB, GSDMC, GSDMD, GSDME/DNFA5, and PVJK/GSDMF. GSDMs possess a C-terminal repressor domain, cytotoxic N-terminal domain, and flexible linker domain (except ...
Ju Zou +9 more
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Pyroptosis: shedding light on the mechanisms and links with cancers
Frontiers in Immunology, 2023 Pyroptosis, a novel form of programmed cell death (PCD) discovered after apoptosis and necrosis, is characterized by cell swelling, cytomembrane perforation and lysis, chromatin DNA fragmentation, and the release of intracellular proinflammatory contents,
Hong-mei You +5 more
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BMC Biology, 2022 Background Gasdermins are ancient (>500million-years-ago) proteins, constituting a family of pore-forming proteins that allow the release of intracellular content including proinflammatory cytokines.
Diego Angosto-Bazarra +5 more
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Research Progress of Pyroptosis in Alzheimer’s Disease
Frontiers in Molecular Neuroscience, 2022 Alzheimer’s disease (AD) is a disease characterized by insidious and progressive neurodegeneration, with clinical syndromes of memory and visuospatial skills damage.
Weiyue Xue, Di Cui, Ye Qiu
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Role of Pyroptosis in Inflammatory Bowel Disease (IBD): From Gasdermins to DAMPs
Frontiers in Pharmacology, 2022 Pyroptosis is a pro-inflammatory cell death executed by gasdermin family proteins that involve the formation of pores on cells, recognition of danger signals, and release of pro-inflammatory cytokines IL-1β and IL-18.
Shuxia Zhang +4 more
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Role of Pyroptosis in Acetaminophen-Induced Hepatotoxicity
Livers, 2022 Acetaminophen (APAP) is a widely used pain reliever that can cause liver injury or liver failure in response to an overdose. Understanding the mechanisms of APAP-induced cell death is critical for identifying new therapeutic targets.
Hartmut Jaeschke +2 more
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Gasdermins assemble; recent developments in bacteriology and pharmacology
Frontiers in Immunology, 2023 The discovery of gasdermin D (GSDMD) as the terminal executioner of pyroptosis provided a large piece of the cell death puzzle, whilst simultaneously and firmly putting the gasdermin family into the limelight.
Claudine S. Greenwood +4 more
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NLRP3 Inflammasome and Pyroptosis in Liver Pathophysiology: The Emerging Relevance of Nrf2 Inducers
Antioxidants, 2022 Inflammasomes, particularly the nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin domain containing 3 (NLRP3) inflammasome, apparently serve as crucial regulators of the inflammatory response through the activation of Caspase-1 ...
Laura Hurtado-Navarro +4 more
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