Results 1 to 10 of about 25,524 (331)

Intestinal epithelial Gasdermin C is induced by IL-4R/STAT6 signaling but is dispensable for gut immune homeostasis [PDF]

Scientific Reports
Gasdermin C is one of the least studied members of the gasdermin family of proteins, known for their critical involvement in pyroptosis and host defense.
Reyes Gámez-Belmonte, Yara Wagner, Mousumi Mahapatro, Ru Wang, Lena Erkert, Miguel González-Acera, Roodline Cineus, Saskia Hainbuch, Jay V. Patankar, David Voehringer, Ahmed N. Hegazy, Markus F. Neurath, Stefan Wirtz, Christoph Becker   +13 more
doaj   +2 more sources

Caspase-1 activates gasdermin A in non-mammals [PDF]

eLife
Gasdermins oligomerize to form pores in the cell membrane, causing regulated lytic cell death called pyroptosis. Mammals encode five gasdermins that can trigger pyroptosis: GSDMA, B, C, D, and E.
Zachary Paul Billman, Stephen Bela Kovacs, Bo Wei, Kidong Kang, Ousmane H Cissé, Edward A Miao   +5 more
doaj   +3 more sources

Gasdermin E deficiency limits inflammation and lung damage during influenza virus infection

Cell Death and Disease
Severe influenza A virus (IAV) infections are associated with hyperinflammation and significant lung damage. Gasdermin E (GSDME) mediates pyroptosis, a lytic and inflammatory type of cell death.
Sarah Rosli, Rebecca L. Ambrose, C. Harpur, Maggie Lam, Christopher J. Hodges, Kristian T. Barry, Alison C. West, Ashley Mansell, Kate E. Lawlor, M. Tate   +9 more
semanticscholar   +1 more source

NcRNA Regulated Pyroptosis in Liver Diseases and Traditional Chinese Medicine Intervention: A Narrative Review

Journal of Inflammation Research
Jiasheng Deng,1,* Le Qin,2,* Sulang Qin,3,* Ruisheng Wu,1 Guidong Huang,1 Yibin Fang,4 Lanlan Huang,4 Zhipin Zhou4 1School of Pharmacy, Guangxi University of Chinese Medicine, Nanning, Guangxi, 530200, People’s Republic of China; 2Department ...
Deng J, Qin L, Qin S, Wu R, Huang G, Fang Y, Huang L, Zhou Z   +7 more
doaj  

Cardiolipin oxidized by ROS from complex II acts as a target of gasdermin D to drive mitochondrial pore and heart dysfunction in endotoxemia.

Cell Reports
Cardiac dysfunction, an early complication of endotoxemia, is the major cause of death in intensive care units. No specific therapy is available at present for this cardiac dysfunction.
Yan Tang, Junru Wu, Xu Sun, Shasha Tan, Wenbo Li, Siyu Yin, Lun Liu, Yuanyuan Chen, Yuan-Yuan Liu, Qian Tan, You-Jing Jiang, Wenjing Yang, Wei Huang, Chun-Yan Weng, Qing Wu, Yao Lu, Hong Yuan, Qingzhong Xiao, Alex F. Chen, Qin Xu, T. Billiar, Jingjing Cai   +21 more
semanticscholar   +1 more source

USP18 Antagonizes Pyroptosis by Facilitating Selective Autophagic Degradation of Gasdermin D

Research
As a key executioner of pyroptosis, Gasdermin D (GSDMD) plays a crucial role in host defense and emerges as an essential therapeutic target in the treatment of inflammatory diseases.
Li-Qiu Wang, Mengqiu Li, Guangyu Lian, Shuai Yang, Yaoxing Wu, Jun Cui   +5 more
semanticscholar   +1 more source

Unlocking the potential of pyroptosis in tumor immunotherapy: a new horizon in cancer treatment

Frontiers in Immunology
BackgroundThe interaction between pyroptosis—a form of programmed cell death—and tumor immunity represents a burgeoning field of interest. Pyroptosis exhibits a dual role in cancer: it can both promote tumor development and counteract it by activating ...
Qinan Yin, Qinan Yin, Si-Yuan Song, Yuan Bian, Yuan Bian, Yiping Wang, Anchen Deng, Jianzhen Lv, Yi Wang, Yi Wang   +9 more
doaj   +1 more source

Starvation-induced phosphorylation activates gasdermin A to initiate pyroptosis.

Cell Reports
Pyroptosis, a pro-inflammatory form of programmed cell death, is crucial for host defense against pathogens and danger signals. Proteolytic cleavage of gasdermin proteins B-E (GSDMB-GSDME) is well established as a trigger for pyroptosis, but the ...
Xin-Ran Li, Xiao Li, Cong Xiang, Jin Cao, Jian-sheng Guo, Shilei Zhu, Jia-Yan Tan, Lijing Wang, Chun Gao, Shengduo Liu, Li-Feng Zhao, Bo Yuan, Pinglong Xu, Bing Yang, Dali Li, Bin Zhao, Xin-Hua Feng   +16 more
semanticscholar   +1 more source

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

Nature, 2017
Yu-Peng Wang, Wenqing Gao, Xu-Yan Shi, Jing-Jin Ding, Wang Liu, Hua-Bin He, Kun Wang, F. Shao   +7 more
semanticscholar   +1 more source

Gasdermin D cysteine residues synergistically control its palmitoylation-mediated membrane targeting and assembly

EMBO Journal
Gasdermin D (GSDMD) executes the cell death program of pyroptosis by assembling into oligomers that permeabilize the plasma membrane. Here, by single-molecule imaging, we elucidate the yet unclear mechanism of Gasdermin D pore assembly and the role of ...
E. Margheritis, Shirin Kappelhoff, John S. H. Danial, Nadine Gehle, Wladislaw Kohl, Rainer Kurre, Ayelén González Montoro, Katia Cosentino   +7 more
semanticscholar   +1 more source