Results 1 to 10 of about 17,935 (273)

Structural basis and regulation of GSDME pore formation. [PDF]

Nat Commun
Teran E, Tian T, Wang C, Wang X, Wang J, Ni D, Rathinam VA, Ruan J.   +7 more
europepmc   +1 more source

Advances in understanding the NLRP3 inflammasome‑mediated mechanisms and therapeutic targets in diabetic nephropathy (Review). [PDF]

Int J Mol Med
Wang X, Li S, Ge X, Xie T, Li S, Yuan R, Li T, Yuan H.   +7 more
europepmc   +1 more source

Recalibrating cell fate: targeting the mitochondrial signaling hub with natural active compounds to inhibit regulated cell death in diabetic kidney disease. [PDF]

Front Physiol
Dai Y, Wu C, Zheng J, Zhao K, Hua S, Sun J, Zhu H, Luo J, Shi J, Han L, Wang L, Liu P.   +11 more
europepmc   +1 more source

Disulfiram Attenuates Bleomycin-Induced Lung Inflammation and Fibrosis with Reduced Endothelial Pyroptosis and Neutrophil Adhesion. [PDF]

J Inflamm Res
Sun CY, Yang WL, Shen HC, Yu WK, Chen WC, Yang KY.   +5 more
europepmc   +1 more source

Gasdermin and Gasdermin-Like Pore-Forming Proteins in Invertebrates, Fungi and Bacteria

Journal of Molecular Biology, 2022
The gasdermin family of pore-forming proteins (PFPs) has recently emerged as key molecular players controlling immune-related cell death in mammals. Characterized mammalian gasdermins are activated through proteolytic cleavage by caspases or serine proteases, which remove an inhibitory carboxy-terminal domain, allowing the pore-formation process ...
Asen Daskalov, N Louise Glass
exaly   +3 more sources

Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway

Cell, 2021
Charles L Evavold, Iva Hafner-Bratkovič, Pascal Devant   +2 more
exaly  

Gasdermin D licenses MHCII induction to maintain food tolerance in small intestine

Cell, 2023
Kaixin He, Zheng Wei, Richard A Flavell   +2 more
exaly  

Pyroptosis and the cellular consequences of gasdermin pores

Seminars in Immunology, 2023
Susan L Fink
exaly  

Mechanistic Insights into Gasdermin Pore Formation and Regulation in Pyroptosis

Journal of Molecular Biology, 2022
Chengliang Wang, Jianbin Ruan
exaly  

Chemical modulation of gasdermin D activity: Therapeutic implications and consequences

Seminars in Immunology, 2023
Bowen Zhou, Derek W Abbott
exaly