Results 1 to 10 of about 13,805 (203)

The Regulation and Modification of GSDMD Signaling in Diseases

Frontiers in Immunology, 2022
Gasdermin D (GSDMD) serves as a key executor to trigger pyroptosis and is emerging as an attractive checkpoint in host defense, inflammatory, autoimmune diseases, and many other systemic diseases.
Zihao Li, Senlin Ji, Mei-Ling Jiang, Yun Xu, Yun Xu, Yun Xu, Yun Xu, Yun Xu, Cun-Jin Zhang, Cun-Jin Zhang, Cun-Jin Zhang, Cun-Jin Zhang, Cun-Jin Zhang   +12 more
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GSDMD contributes to myocardial reperfusion injury by regulating pyroptosis

Frontiers in Immunology, 2022
BackgroundGasdermin D (GSDMD) plays an essential role in the pathway of pyroptosis. However, whether GSDMD participates in myocardial ischaemia/reperfusion injury (MI/RI) remains poorly understood.MethodsSerum levels of GSDMD and IL-18 in ST-segment ...
Xiaomiao Ye, Peng Zhang, Yuting Zhang, Jingyun Luan, Caili Xu, Zhengyu Wu, Dianwen Ju, Dianwen Ju, Wei Hu   +8 more
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Muscarinic acetylcholine M1 receptor regulates pyroptosis of prostate cancer cells through Caspase-1/GSDMD pathway

Di-san junyi daxue xuebao, 2021
Objective To determine the effect of muscarinic acetylcholine M1 receptor (CHRM1) on pyroptosis of prostate cancer cells and investigate its possible molecular mechanism. Methods Pirenzepine (PIN), a specific CHRM1 antagonist, and bethanechol (BETH), its
CHEN Jinying, ZHANG Mi, ZENG Yan, HUANG Yanping, CHEN Fangfang, WANG Qianhui, XU Chen   +6 more
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Curcumin activates NLRC4, AIM2, and IFI16 inflammasomes and induces pyroptosis by up-regulated ISG3 transcript factor in acute myeloid leukemia cell lines

Cancer Biology & Therapy, 2022
Curcumin, the primary bioactive component isolated from turmeric, has been found to possess a variety of biological functions, including anti-leukemia activity. However, the effect of curcumin in different leukemia cells vary.
Yuru Zhou, Yunyuan Kong, Mei Jiang, Linju Kuang, Jinhua Wan, Shuyuan Liu, Qian Zhang, Kuai Yu, Na Li, Aiping Le, Zhanglin Zhang   +10 more
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Gasdermin D-mediated pyroptosis: mechanisms, diseases, and inhibitors

Frontiers in Immunology, 2023
Gasdermin D (GSDMD)-mediated pyroptosis and downstream inflammation are important self-protection mechanisms against stimuli and infections. Hosts can defend against intracellular bacterial infections by inducing cell pyroptosis, which triggers the ...
Zhen Dai, Wan-Cong Liu, Xiao-Yi Chen, Xiao Wang, Jun-Long Li, Xiang Zhang   +5 more
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Down-regulation of KLF9 ameliorates LPS-caused acute lung injury and inflammation in mice via reducing GSDMD expression

Autoimmunity, 2022
Acute lung injury (ALI) is considered as a severe respiratory disease with aggravated inflammatory responses. Krüppel-like factor 9 (KLF9), a member of KLF family, has been reported to be involved in inflammatory disorders. However, the effect of KLF9 in
Renliang Qu, Jingjing Liu, Lili Feng, Lianbing Li, Junwei Liu, Fengnan Sun, Lin Sun   +6 more
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Host Gasdermin D restrains systemic endotoxemia by capturing Proteobacteria in the colon of high-fat diet-feeding mice

Gut Microbes, 2021
Gasdermin D (GSDMD) functions as a key pyroptotic executor through its secreted N-terminal domain (GSDMD-N). However, the functional relevance and mechanistic basis of the precise roles of host colonic GSDMD in high-fat diet (HFD)-induced gut dysbiosis ...
Yujie Shi, Yixin Zou, Yonghong Xiong, Shiyao Zhang, Mingming Song, Xiaofei An, Chang Liu, Wenxiang Zhang, Siyu Chen   +8 more
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Translocation of gasdermin D induced mitochondrial injury and mitophagy mediated quality control in lipopolysaccharide related cardiomyocyte injury

Clinical and Translational Medicine, 2022
Backgrounds Inflammation underlies the mechanism of different kinds of heart disease. Cytoplasmic membrane localized N‐terminal fragment of gasdermin‐D (GSDMD‐N) could induce inflammatory injury to cardiomyocyte.
Ziqing Yu, Zilong Xiao, Lichun Guan, Pei Bao, Yong Yu, Yixiu Liang, Minghui Li, Zhenzhen Huang, Xueying Chen, Ruizhen Chen, Yangang Su, Junbo Ge   +11 more
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Gasdermin D protects against Streptococcus equi subsp. zooepidemicus infection through macrophage pyroptosis

Frontiers in Immunology, 2022
Streptococcus equi subsp. zooepidemicus (S. zooepidemicus, SEZ) is an essential zoonotic bacterial pathogen that can cause various inflammation, such as meningitis, endocarditis, and pneumonia. Gasdermin D (GSDMD) is involved in cytokine release and cell
Guobin Xu, Zheng Guo, Yuxuan Liu, Yalin Yang, Yongjin Lin, Chunliu Li, Yunfei Huang, Yunfei Huang, Qiang Fu, Qiang Fu   +9 more
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Gasdermin D Inhibits Coronavirus Infection by Promoting the Noncanonical Secretion of Beta Interferon

mBio, 2022
Pyroptosis, a programmed cell death, functions as an innate immune effector mechanism and plays a crucial role against microbial invasion. Gasdermin D (GSDMD), as the main pyroptosis effector, mediates pyroptosis and promotes releasing proinflammatory ...
Liyuan Zhao, Liang Li, Mei Xue, Xiang Liu, Chengfan Jiang, Wenzhe Wang, Lijie Tang, Li Feng, Pinghuang Liu   +8 more
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