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The Regulation and Modification of GSDMD Signaling in Diseases
Frontiers in Immunology, 2022 Gasdermin D (GSDMD) serves as a key executor to trigger pyroptosis and is emerging as an attractive checkpoint in host defense, inflammatory, autoimmune diseases, and many other systemic diseases.
Zihao Li +12 more
exaly +5 more sources
CellsGasdermin D (GSDMD) is a key executor of pyroptosis, a form of inflammation-induced programmed cell death. Recently, GSDMD has been shown to play important roles in the development of various inflammatory-related human diseases including heart failure ...
Xiaolong Yang
exaly +4 more sources
GSDMD contributes to myocardial reperfusion injury by regulating pyroptosis
Frontiers in Immunology, 2022 BackgroundGasdermin D (GSDMD) plays an essential role in the pathway of pyroptosis. However, whether GSDMD participates in myocardial ischaemia/reperfusion injury (MI/RI) remains poorly understood.MethodsSerum levels of GSDMD and IL-18 in ST-segment ...
Xiaomiao Ye +8 more
doaj +3 more sources
Recipient‐derived macrophages mediate acute cardiac allograft rejection via GSDMD‐induced pyroptosis mechanism [PDF]
Clinical and Translational MedicineObjective To determine whether macrophage gasdermin D (GSDMD)‐dependent pyroptosis drives acute cardiac allograft rejection and whether targeting GSDMD improves graft survival. Methods GSDMD activation was assessed by immunoblotting.
Bixian Luo +8 more
doaj +2 more sources
Di-san junyi daxue xuebao, 2021 Objective To determine the effect of muscarinic acetylcholine M1 receptor (CHRM1) on pyroptosis of prostate cancer cells and investigate its possible molecular mechanism. Methods Pirenzepine (PIN), a specific CHRM1 antagonist, and bethanechol (BETH), its
CHEN Jinying +6 more
doaj +1 more source
Cancer Biology & Therapy, 2022 Curcumin, the primary bioactive component isolated from turmeric, has been found to possess a variety of biological functions, including anti-leukemia activity. However, the effect of curcumin in different leukemia cells vary.
Yuru Zhou +10 more
doaj +1 more source
Autoimmunity, 2022 Acute lung injury (ALI) is considered as a severe respiratory disease with aggravated inflammatory responses. Krüppel-like factor 9 (KLF9), a member of KLF family, has been reported to be involved in inflammatory disorders. However, the effect of KLF9 in
Renliang Qu +6 more
doaj +1 more source
Gasdermin D-mediated pyroptosis: mechanisms, diseases, and inhibitors
Frontiers in Immunology, 2023 Gasdermin D (GSDMD)-mediated pyroptosis and downstream inflammation are important self-protection mechanisms against stimuli and infections. Hosts can defend against intracellular bacterial infections by inducing cell pyroptosis, which triggers the ...
Zhen Dai +5 more
doaj +1 more source
Gut Microbes, 2021 Gasdermin D (GSDMD) functions as a key pyroptotic executor through its secreted N-terminal domain (GSDMD-N). However, the functional relevance and mechanistic basis of the precise roles of host colonic GSDMD in high-fat diet (HFD)-induced gut dysbiosis ...
Yujie Shi +8 more
doaj +1 more source
Development of diagnostic and prognostic biomarker models for knee osteoarthritis based on NLRP3 inflammasome activation [PDF]
Journal of Medical BiochemistryBackground: This study aimed to characterize the expression profiles of the NOD-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome and its downstream effectors [Interleukin (IL)-1b, IL-18, and Gasdermin-D (GSDMD)] in degenerative knee ...
Xiong Shui +4 more
doaj +1 more source