Results 1 to 10 of about 14,672 (225)

The Regulation and Modification of GSDMD Signaling in Diseases

Frontiers in Immunology, 2022
Gasdermin D (GSDMD) serves as a key executor to trigger pyroptosis and is emerging as an attractive checkpoint in host defense, inflammatory, autoimmune diseases, and many other systemic diseases.
Xu Yun
exaly   +5 more sources

GSDMD contributes to myocardial reperfusion injury by regulating pyroptosis

Frontiers in Immunology, 2022
BackgroundGasdermin D (GSDMD) plays an essential role in the pathway of pyroptosis. However, whether GSDMD participates in myocardial ischaemia/reperfusion injury (MI/RI) remains poorly understood.MethodsSerum levels of GSDMD and IL-18 in ST-segment ...
Xiaomiao Ye, Peng Zhang, Yuting Zhang, Jingyun Luan, Caili Xu, Zhengyu Wu, Dianwen Ju, Dianwen Ju, Wei Hu   +8 more
doaj   +3 more sources

A Novel Bioluminescent Biosensor Quantifying Intramolecular Interaction and Levels of Pyroptosis Effector GSDMD

Cells
Gasdermin D (GSDMD) is a key executor of pyroptosis, a form of inflammation-induced programmed cell death. Recently, GSDMD has been shown to play important roles in the development of various inflammatory-related human diseases including heart failure ...
Xiaolong Yang
exaly   +3 more sources

Muscarinic acetylcholine M1 receptor regulates pyroptosis of prostate cancer cells through Caspase-1/GSDMD pathway

Di-san junyi daxue xuebao, 2021
Objective To determine the effect of muscarinic acetylcholine M1 receptor (CHRM1) on pyroptosis of prostate cancer cells and investigate its possible molecular mechanism. Methods Pirenzepine (PIN), a specific CHRM1 antagonist, and bethanechol (BETH), its
CHEN Jinying, ZHANG Mi, ZENG Yan, HUANG Yanping, CHEN Fangfang, WANG Qianhui, XU Chen   +6 more
doaj   +1 more source

Curcumin activates NLRC4, AIM2, and IFI16 inflammasomes and induces pyroptosis by up-regulated ISG3 transcript factor in acute myeloid leukemia cell lines

Cancer Biology & Therapy, 2022
Curcumin, the primary bioactive component isolated from turmeric, has been found to possess a variety of biological functions, including anti-leukemia activity. However, the effect of curcumin in different leukemia cells vary.
Yuru Zhou, Yunyuan Kong, Mei Jiang, Linju Kuang, Jinhua Wan, Shuyuan Liu, Qian Zhang, Kuai Yu, Na Li, Aiping Le, Zhanglin Zhang   +10 more
doaj   +1 more source

Down-regulation of KLF9 ameliorates LPS-caused acute lung injury and inflammation in mice via reducing GSDMD expression

Autoimmunity, 2022
Acute lung injury (ALI) is considered as a severe respiratory disease with aggravated inflammatory responses. Krüppel-like factor 9 (KLF9), a member of KLF family, has been reported to be involved in inflammatory disorders. However, the effect of KLF9 in
Renliang Qu, Jingjing Liu, Lili Feng, Lianbing Li, Junwei Liu, Fengnan Sun, Lin Sun   +6 more
doaj   +1 more source

Gasdermin D-mediated pyroptosis: mechanisms, diseases, and inhibitors

Frontiers in Immunology, 2023
Gasdermin D (GSDMD)-mediated pyroptosis and downstream inflammation are important self-protection mechanisms against stimuli and infections. Hosts can defend against intracellular bacterial infections by inducing cell pyroptosis, which triggers the ...
Zhen Dai, Wan-Cong Liu, Xiao-Yi Chen, Xiao Wang, Jun-Long Li, Xiang Zhang   +5 more
doaj   +1 more source

Host Gasdermin D restrains systemic endotoxemia by capturing Proteobacteria in the colon of high-fat diet-feeding mice

Gut Microbes, 2021
Gasdermin D (GSDMD) functions as a key pyroptotic executor through its secreted N-terminal domain (GSDMD-N). However, the functional relevance and mechanistic basis of the precise roles of host colonic GSDMD in high-fat diet (HFD)-induced gut dysbiosis ...
Yujie Shi, Yixin Zou, Yonghong Xiong, Shiyao Zhang, Mingming Song, Xiaofei An, Chang Liu, Wenxiang Zhang, Siyu Chen   +8 more
doaj   +1 more source

Translocation of gasdermin D induced mitochondrial injury and mitophagy mediated quality control in lipopolysaccharide related cardiomyocyte injury

Clinical and Translational Medicine, 2022
Backgrounds Inflammation underlies the mechanism of different kinds of heart disease. Cytoplasmic membrane localized N‐terminal fragment of gasdermin‐D (GSDMD‐N) could induce inflammatory injury to cardiomyocyte.
Ziqing Yu, Zilong Xiao, Lichun Guan, Pei Bao, Yong Yu, Yixiu Liang, Minghui Li, Zhenzhen Huang, Xueying Chen, Ruizhen Chen, Yangang Su, Junbo Ge   +11 more
doaj   +1 more source

Increased ratio of Th1/Th2 cells promotes pyroptosis of placental trophoblast cells in early-onset severe preeclampsia

Di-san junyi daxue xuebao, 2022
Objective To investigate the effect of Th1/Th2 ratio on pyroptosis of placental trophoblast cells in early-onset severe preeclampsia. Methods The clinical data of 55 cases of early-onset severe preeclampsia diagnosed in our hospital from June 2018 to ...
WANG Haijiao, WANG Yi, HE Hongmei, QI Lin, CUI Yujiao, LIU Li   +5 more
doaj   +1 more source