Results 41 to 50 of about 17,882 (284)
N-GSDMD trafficking to neutrophil organelles facilitates IL-1β release independently of plasma membrane pores and pyroptosis [PDF]
, 2020 Gasdermin-D (GSDMD) in inflammasome-activated macrophages is cleaved by caspase-1 to generate N-GSDMD fragments. N-GSDMD then oligomerizes in the plasma membrane (PM) to form pores that increase membrane permeability, leading to pyroptosis and IL-1β ...
Karmakar, Mausita +12 more
core +1 more source
mBio, 2022 Pyroptosis, a programmed cell death, functions as an innate immune effector mechanism and plays a crucial role against microbial invasion. Gasdermin D (GSDMD), as the main pyroptosis effector, mediates pyroptosis and promotes releasing proinflammatory ...
Liyuan Zhao +8 more
doaj +1 more source
GSDMD deficiency ameliorates hyperoxia-induced BPD and ROP in neonatal mice
, 2023 Bronchopulmonary dysplasia (BPD) and retinopathy of prematurity (ROP) are among the most common morbidities affecting extremely premature infants who receive oxygen therapy. Many clinical studies indicate that BPD is associated with advanced ROP. However,
Duncan, Matthew R. +9 more
core +1 more source
Frontiers in Immunology, 2022 Streptococcus equi subsp. zooepidemicus (S. zooepidemicus, SEZ) is an essential zoonotic bacterial pathogen that can cause various inflammation, such as meningitis, endocarditis, and pneumonia. Gasdermin D (GSDMD) is involved in cytokine release and cell
Guobin Xu +9 more
doaj +1 more source
Predicated cleavage site for caspase-4 on GSDMD.
, 2022 The molecular weight of full length rGSDMD is 81 kDa as a GST tag is linked to NT of rGSDMD, whereas CT is tagged by His. (A) Cleavage of 5 μg purified recombinant GSDMD with 6U recombinant caspase-4 visualized by Coomassie blue staining of the protein ...
Kris Chadee (249039) +2 more
core +1 more source
From pattern recognition to pro-inflammatory cell death - Functional characterization of the proteins NLRP7 and GSDMD [PDF]
, 2023 Inflammasomes are cytosolic multi-protein complexes that form in response to infection or other harmful stimuli to induce innate immune responses.
Kopp, Anja
core +1 more source
Gasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death
Cell Reports, 2018 Summary: Gasdermin D (GSDMD) is considered a proinflammatory factor that mediates pyroptosis in macrophages to protect hosts from intracellular bacteria.
Hiroto Kambara +14 more
doaj +1 more source
Cathepsin G inhibition by Serpinb1 and Serpinb6 prevents programmed necrosis in neutrophils and monocytes and reduces GSDMD-driven inflammation [PDF]
, 2019 Neutrophil granule serine proteases contribute to immune responses through cleavage of microbial toxins and structural proteins. They induce tissue damage and modulate inflammation if levels exceed their inhibitors.
Burgener, Sabrina Sofia +7 more
core +2 more sources
, 2022 Pyroptosis plays a significant role in neuroinflammation after traumatic brain injury (TBI). However, the role of pyroptosis executor Gasdermin D (GSDMD) in neurological deficits and neuropathological alterations after TBI have not been elucidated.
Hao Du (748002) +4 more
core +1 more source
, 2023 Glioblastoma (GBM) is the most common aggressive malignant brain cancer and is chemo- and radioresistant, with poor therapeutic outcomes. The “double-edged sword” of virus-induced cell death could be a potential solution if the oncolytic virus ...
Chiou-Feng Lin +5 more
core +2 more sources