Results 1 to 10 of about 187,152 (231)

Mitochondrial-Encoded Peptide MOTS-c, Diabetes, and Aging-Related Diseases [PDF]

Diabetes & Metabolism Journal, 2023
Mitochondria are complex metabolic organelles with manifold pathophysiological implications in diabetes. Currently published mitochondrial-encoded peptides, which are expressed from the mitochondrial open reading frame of the 12S ribosomal RNA type-c ...
Byung Soo Kong, Changhan Lee, Young Min Cho   +2 more
doaj   +1 more source

The ARM repeat domain of hemocyanin interacts with MKK4 to modulate antimicrobial peptides expression

iScience, 2022
Summary: The mitogen-activated protein kinase (MAPK) intracellular signaling pathway mediates numerous biological processes, including antimicrobial immune response by inducing antimicrobial peptides (AMPs) production.
Jude Juventus Aweya, Kaiying Zhuang, Yiqi Liu, Jiaohong Fan, Defu Yao, Fan Wang, Xiaohan Chen, Shengkang Li, Hongyu Ma, Yueling Zhang   +9 more
doaj   +1 more source

Signal Peptide Cleavage and Internal Targeting Signals Direct the Hepatitis C Virus p7 Protein to Distinct Intracellular Membranes [PDF]

Journal of Virology, 2005
ABSTRACT The hepatitis C virus (HCV) p7 protein forms an amantadine-sensitive ion channel required for viral replication in chimpanzees, though its precise role in the life cycle of HCV is unknown. In an attempt to gain some insights into p7 function, we examined the intracellular localization of p7 using epitope tags and an anti-p7 peptide ...
Griffin, Stephen, Clarke, Dean, McCormick, Christopher, Rowlands, David, Harris, Mark   +4 more
openaire   +3 more sources

Digoxigenin-Labeled Peptides for the Immunological Quantification of Intracellular Signaling Proteins: Application to the MAP Kinase Kinase Isoform MEK2 [PDF]

BioTechniques, 1997
Two competitive enzyme immunoassays using digoxigenin-labeled peptides have been developed for the quantification of the protein kinase MEK2 in cell extracts. Rabbit polyclonal antibodies directed against either the amino-terminal or proline-rich amino acid sequences of MEK2 were used for the immunoconcentration of the protein.
Charles Blais, Guy Drapeau, Sylvain Meloche, Réjean Morais, Albert Adam   +4 more
openaire   +3 more sources

Novel soybean peptide iglycin ameliorates insulin resistance of high-fat diet fed C57BL/6J mice and differentiated 3T3L1 adipocytes with improvement of insulin signaling and mitochondrial function

Food Science and Human Wellness, 2022
Soy consumption has been associated with potential health benefits in reducing chronic diseases. These physiological functions have been attributed to soy proteins or more commonly to bioactive peptides.
Yinghuan Wu, Ran Zhao, Minxia Li, Huiyun Li, Zhengwang Chen, Yanying Zhao   +5 more
doaj   +1 more source

Intracellular artificial supramolecules based on de novo designed Y15 peptides

Nature Communications, 2021
Self-assembling peptides (SAPs) can be used to build biomaterials, but genetically encoded SAPs have rarely been used as building blocks in cells.
Takayuki Miki, Taichi Nakai, Masahiro Hashimoto, Keigo Kajiwara, Hiroshi Tsutsumi, Hisakazu Mihara   +5 more
doaj   +1 more source

Analysis of the Yeast Peptidome and Comparison with the Human Peptidome. [PDF]

PLoS ONE, 2016
Peptides function as signaling molecules in species as diverse as humans and yeast. Mass spectrometry-based peptidomics techniques provide a relatively unbiased method to assess the peptidome of biological samples.
Sayani Dasgupta, Ciyu Yang, Leandro M Castro, Alexandre K Tashima, Emer S Ferro, Robyn D Moir, Ian M Willis, Lloyd D Fricker   +7 more
doaj   +1 more source

A Cyclic Peptide Mimicking the Third Intracellular Loop of the V2 Vasopressin Receptor Inhibits Signaling through Its Interaction with Receptor Dimer and G Protein [PDF]

Journal of Biological Chemistry, 2004
In this study, we investigated the mechanism by which a peptide mimicking the third cytoplasmic loop of the vasopressin V2 receptor inhibits signaling. This loop was synthesized as a cyclic peptide (i3 cyc) that adopted defined secondary structure in solution.
Sébastien, Granier, Sonia, Terrillon, Robert, Pascal, Hélène, Déméné, Michel, Bouvier, Gilles, Guillon, Christiane, Mendre   +6 more
openaire   +2 more sources

Food-derived bioactive peptides: Mechanisms of action underlying inflammation and oxidative stress in the central nervous system

Food Chemistry Advances, 2022
There is a great interest in neuroprotective molecules capable of inhibiting the signaling, transduction and amplification of inflammatory and oxidative pathways to reverse or prevent brain cell damage and neurodegeneration.
Fabiana Galland, Juliana Santos de Espindola, Daniel Saraiva Lopes, Milena Ferreira Taccola, Maria Teresa Bertoldo Pacheco   +4 more
doaj   +1 more source

Regulator of G-Protein Signaling (RGS) Protein Modulation of Opioid Receptor Signaling as a Potential Target for Pain Management

Frontiers in Molecular Neuroscience, 2020
Opioid drugs are the gold standard for the management of pain, but their use is severely limited by dangerous and unpleasant side effects. All clinically available opioid analgesics bind to and activate the mu-opioid receptor (MOR), a heterotrimeric G ...
Nicolas B. Senese, Nicolas B. Senese, Ram Kandasamy, Ram Kandasamy, Kelsey E. Kochan, John R. Traynor, John R. Traynor   +6 more
doaj   +1 more source