Results 31 to 40 of about 198,097 (261)

Theoretical and Computational Studies of Peptides and Receptors of the Insulin Family

Membranes, 2015
Synergistic interactions among peptides and receptors of the insulin family are required for glucose homeostasis, normal cellular growth and development, proliferation, differentiation and other metabolic processes. The peptides of the insulin family are
Harish Vashisth
doaj   +1 more source

Misfolded proteins bind and activate death receptor 5 to trigger apoptosis during unresolved endoplasmic reticulum stress

eLife, 2020
Disruption of protein folding in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR)—a signaling network that ultimately determines cell fate.
Mable Lam, Scot A Marsters, Avi Ashkenazi, Peter Walter   +3 more
doaj   +1 more source

A Global Review on Short Peptides: Frontiers and Perspectives

Molecules, 2021
Peptides are fragments of proteins that carry out biological functions. They act as signaling entities via all domains of life and interfere with protein-protein interactions, which are indispensable in bio-processes.
Vasso Apostolopoulos, Joanna Bojarska, Tsun-Thai Chai, Sherif Elnagdy, Krzysztof Kaczmarek, John Matsoukas, Roger New, Keykavous Parang, Octavio Paredes Lopez, Hamideh Parhiz, Conrad O. Perera, Monica Pickholz, Milan Remko, Michele Saviano, Mariusz Skwarczynski, Yefeng Tang, Wojciech M. Wolf, Taku Yoshiya, Janusz Zabrocki, Piotr Zielenkiewicz, Maha AlKhazindar, Vanessa Barriga, Konstantinos Kelaidonis, Elham Mousavinezhad Sarasia, Istvan Toth   +24 more
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Clinical Determinants of Urinary Podocyte Biomarkers and Their Feasibility in Paraprotein-Related Kidney Disease

Diagnostics
Background/Objectives: Kidney injury is a frequent complication of multiple myeloma (MM) and monoclonal gammopathies. Podocyte stress markers, such as urinary nephrin and podocin, have been studied in other renal diseases but their utility in paraprotein-
Oliver Helk, Ludwig Wagner, Gürkan Sengölge, Thomas Reiter, Daniela Gerges, Hermine Agis, Wolfgang Winnicki   +6 more
doaj   +1 more source

Towards the systematic discovery of signal transduction networks using phosphorylation dynamics data

BMC Bioinformatics, 2010
Background Phosphorylation is a ubiquitous and fundamental regulatory mechanism that controls signal transduction in living cells. The number of identified phosphoproteins and their phosphosites is rapidly increasing as a result of recent mass ...
Yachie Nozomu, Imamura Haruna, Saito Rintaro, Ishihama Yasushi, Tomita Masaru   +4 more
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Host intracellular signaling events and pro-inflammatory cytokine production in African trypanosomiasis

Frontiers in Immunology, 2016
Pathogens such as bacteria, viruses and parasites possess specific molecules or proteins that are recognized by several host innate immune receptors leading to the activation of several intracellular signaling molecules and pathways.
Shiby M Kuriakose, Rani eSingh, JUDE EZEH UZONNA   +2 more
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Molecular Dynamics Simulations Reveal Canonical Conformations in Different pMHC/TCR Interactions

Cells, 2020
The major defense system against microbial pathogens in vertebrates is the adaptive immune response and represents an effective mechanism in cancer surveillance. T cells represent an essential component of this complex system.
Josephine Alba, Lorenzo Di Rienzo, Edoardo Milanetti, Oreste Acuto, Marco D’Abramo   +4 more
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Effects of frog skin peptide temporin-1CEa and its analogs on ox-LDL induced macrophage-derived foam cells

Frontiers in Pharmacology, 2023
Purpose: Atherosclerosis is one of the most important pathological foundations of cardiovascular and cerebrovascular diseases with high morbidity and mortality.
Xue-Feng Yang, Xue-Feng Yang, Xin Liu, Xiao-Yi Yan, De-Jing Shang   +4 more
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Pathophysiology of GPCR Homo- and Heterodimerization: Special Emphasis on Somatostatin Receptors

Pharmaceuticals, 2012
G-protein coupled receptors (GPCRs) are cell surface proteins responsible for translating >80% of extracellular reception to intracellular signals.
Rishi K. Somvanshi, Ujendra Kumar
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Regulation of dermal fibroblasts by human neutrophil peptides

Scientific Reports, 2023
Human neutrophil peptides (HNPs) can induce cell proliferation and activation so their growth promoting activities may have potential clinical benefit. This study investigated the effects of HNPs on human dermal fibroblasts.
Nattarika Niwetbowornchai, Thanawat Chaisirirat, Sira Sriswasdi, Supichcha Saithong, Grace Filbertine, Helen L. Wright, Steven W. Edwards, Sita Virakul, Direkrit Chiewchengchol   +8 more
doaj   +1 more source