Results 21 to 30 of about 184,061 (226)
Towards the systematic discovery of signal transduction networks using phosphorylation dynamics data
BMC Bioinformatics, 2010 Background Phosphorylation is a ubiquitous and fundamental regulatory mechanism that controls signal transduction in living cells. The number of identified phosphoproteins and their phosphosites is rapidly increasing as a result of recent mass ...
Yachie Nozomu +4 more
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Molecular Dynamics Simulations Reveal Canonical Conformations in Different pMHC/TCR Interactions
Cells, 2020 The major defense system against microbial pathogens in vertebrates is the adaptive immune response and represents an effective mechanism in cancer surveillance. T cells represent an essential component of this complex system.
Josephine Alba +4 more
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Frontiers in Immunology, 2016 Pathogens such as bacteria, viruses and parasites possess specific molecules or proteins that are recognized by several host innate immune receptors leading to the activation of several intracellular signaling molecules and pathways.
Shiby M Kuriakose +2 more
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Frontiers in Pharmacology, 2023 Purpose: Atherosclerosis is one of the most important pathological foundations of cardiovascular and cerebrovascular diseases with high morbidity and mortality.
Xue-Feng Yang +4 more
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Regulation of dermal fibroblasts by human neutrophil peptides
Scientific Reports, 2023 Human neutrophil peptides (HNPs) can induce cell proliferation and activation so their growth promoting activities may have potential clinical benefit. This study investigated the effects of HNPs on human dermal fibroblasts.
Nattarika Niwetbowornchai +8 more
doaj +1 more source
Pathophysiology of GPCR Homo- and Heterodimerization: Special Emphasis on Somatostatin Receptors
Pharmaceuticals, 2012 G-protein coupled receptors (GPCRs) are cell surface proteins responsible for translating >80% of extracellular reception to intracellular signals.
Rishi K. Somvanshi, Ujendra Kumar
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Resistance to Inhibitors of Cholinesterase 3 (Ric-3) Expression Promotes Selective Protein Associations with the Human α7-Nicotinic Acetylcholine Receptor Interactome. [PDF]
PLoS ONE, 2015 The α7-nicotinic acetylcholine receptor (α7-nAChR) is a ligand-gated ion channel widely expressed in vertebrates and is associated with numerous physiological functions.
Matthew J Mulcahy +4 more
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Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Cells, 2021 T-cell antigen recognition is accompanied by extensive morphological rearrangements of the contact zone between the T-cell and the antigen-presenting cell (APC).
Martin Fölser +4 more
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Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source