Results 21 to 30 of about 198,097 (261)

A Cyclic Peptide Mimicking the Third Intracellular Loop of the V2 Vasopressin Receptor Inhibits Signaling through Its Interaction with Receptor Dimer and G Protein [PDF]

Journal of Biological Chemistry, 2004
In this study, we investigated the mechanism by which a peptide mimicking the third cytoplasmic loop of the vasopressin V2 receptor inhibits signaling. This loop was synthesized as a cyclic peptide (i3 cyc) that adopted defined secondary structure in solution.
Sébastien, Granier, Sonia, Terrillon, Robert, Pascal, Hélène, Déméné, Michel, Bouvier, Gilles, Guillon, Christiane, Mendre   +6 more
openaire   +2 more sources

Food-derived bioactive peptides: Mechanisms of action underlying inflammation and oxidative stress in the central nervous system

Food Chemistry Advances, 2022
There is a great interest in neuroprotective molecules capable of inhibiting the signaling, transduction and amplification of inflammatory and oxidative pathways to reverse or prevent brain cell damage and neurodegeneration.
Fabiana Galland, Juliana Santos de Espindola, Daniel Saraiva Lopes, Milena Ferreira Taccola, Maria Teresa Bertoldo Pacheco   +4 more
doaj   +1 more source

Regulator of G-Protein Signaling (RGS) Protein Modulation of Opioid Receptor Signaling as a Potential Target for Pain Management

Frontiers in Molecular Neuroscience, 2020
Opioid drugs are the gold standard for the management of pain, but their use is severely limited by dangerous and unpleasant side effects. All clinically available opioid analgesics bind to and activate the mu-opioid receptor (MOR), a heterotrimeric G ...
Nicolas B. Senese, Nicolas B. Senese, Ram Kandasamy, Ram Kandasamy, Kelsey E. Kochan, John R. Traynor, John R. Traynor   +6 more
doaj   +1 more source

Signal Protein-Derived Peptides as Functional Probes and Regulators of Intracellular Signaling [PDF]

Journal of Amino Acids, 2011
The functionally important regions of signal proteins participating in their specific interaction and responsible for transduction of hormonal signal into cell are rather short in length, having, as a rule, 8 to 20 amino acid residues. Synthetic peptides corresponding to these regions are able to mimic the activated form of full-size signal protein and
openaire   +2 more sources

Effect of Protein Denaturation and Enzyme Inhibitors on Proteasomal-Mediated Production of Peptides in Human Embryonic Kidney Cells

Biomolecules, 2019
Peptides produced by the proteasome have been proposed to function as signaling molecules that regulate a number of biological processes. In the current study, we used quantitative peptidomics to test whether conditions that affect protein stability ...
Sayani Dasgupta, Michael A. Fishman, Leandro M. Castro, Alexandre K. Tashima, Emer S. Ferro, Lloyd D. Fricker   +5 more
doaj   +1 more source

Targeting GABAAR-Associated Proteins: New Modulators, Labels and Concepts

Frontiers in Molecular Neuroscience, 2019
γ-aminobutyric acid type A receptors (GABAARs) are the major mediators of synaptic inhibition in the brain. Aberrant GABAAR activity or regulation is observed in various neurodevelopmental disorders, neurodegenerative diseases and mental illnesses ...
Vladimir Khayenko, Vladimir Khayenko, Hans Michael Maric, Hans Michael Maric   +3 more
doaj   +1 more source

Potential of known and short prokaryotic protein motifs as a basis for novel peptide-based antibacterial therapeutics: a computational survey.

Frontiers in Microbiology, 2014
Short linear motifs are functional stretches of protein sequence that are of crucial importance for numerous biological processes by mediating protein-protein interactions.
Heini eRuhanen, Heini eRuhanen, Heini eRuhanen, Daniel eHurley, Daniel eHurley, Daniel eHurley, Ambarnil eGhosh, Kevin T O'Brien, Kevin T O'Brien, Kevin T O'Brien, Catrióna R Johnston, Denis Colum Shields, Denis Colum Shields, Denis Colum Shields   +13 more
doaj   +1 more source

Homozygosity for a partial deletion of apoprotein A-V signal peptide results in intracellular missorting of the protein and chylomicronemia in a breast-fed infant

Atherosclerosis, 2014
Deficiency of apoprotein A-V (apoA-V) can cause hypertriglyceridemia. In an 11 months old boy presenting with a severe hypertriglyceridemia, a formerly unknown 24 nucleotide deletion in exon 2 of the APOA5 gene was detected. The homozygous mutation results in an eight amino acid loss in the signal peptide sequence (c.16_39del; p.Ala6_Ala13del ...
Albers, Kirstin, Schlein, Christian, Wenner, Kirsten, Lohse, Peter, Bartelt, Alexander, Heeren, Joerg, Santer, René, Merkel, Martin   +7 more
openaire   +2 more sources

Relationships between Cargo, Cell Penetrating Peptides and Cell Type for Uptake of Non-Covalent Complexes into Live Cells

Pharmaceuticals, 2013
Modulating signaling pathways for research and therapy requires either suppression or expression of selected genes or internalization of proteins such as enzymes, antibodies, nucleotide binding proteins or substrates including nucleoside phosphates and ...
Andrea-Anneliese Keller, Franziska Mussbach, Reinhard Breitling, Peter Hemmerich, Buerk Schaefer, Stefan Lorkowski, Siegmund Reissmann   +6 more
doaj   +1 more source

Evolution of KIPPIS as a versatile platform for evaluating intracellularly functional peptide aptamers

Scientific Reports, 2021
Chimeric proteins have been widely used to evaluate intracellular protein–protein interactions (PPIs) in living cells with various readouts. By combining an interleukin-3-dependent murine cells and chimeric proteins containing a receptor tyrosine kinase ...
Daiki Kashima, Masahiro Kawahara
doaj   +1 more source