Results 21 to 30 of about 17,882 (284)
Human polymorphisms in GSDMD alter the inflammatory response [PDF]
Journal of Biological Chemistry, 2020 Exomic studies have demonstrated that innate immune genes exhibit an even higher degree of variation than the majority of other gene families. However, the phenotypic implications of this genetic variation are not well understood, with effects ranging from hypomorphic to silent to hyperfunctioning.
Joseph K. Rathkey +2 more
openaire +2 more sources
Pore formation by GSDMD is the effector mechanism of pyroptosis [PDF]
The EMBO Journal, 2016 Pyroptosis is a unique, pro‐inflammatory form of lytic cell death that is initiated by the activation of inflammatory caspases. The caspase substrate gasdermin D (GSDMD) plays a critical function in pyroptosis, yet the precise mode of action of this molecule in cell death execution remained unclear. Several recent reports, including a The EMBO Journal
Gaidt, M. +1 more
openaire +3 more sources
Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis [PDF]
Cell, 2020 The pyroptosis execution protein GSDMD is cleaved by inflammasome-activated caspase-1 and LPS-activated caspase-11/4/5. The cleavage unmasks the pore-forming domain from GSDMD-C-terminal domain. How the caspases recognize GSDMD and its connection with caspase activation are unknown.
Kun, Wang +10 more
openaire +2 more sources
Protein Mass Spectrometry on GSDMD Interacting Protein
, 2022 Protein Mass Spectrometry on GSDMD Interacting Protein to identify the likely interaction of GSDMD and PARP ...
Liwei Song (12370613)
core +1 more source
Di-san junyi daxue xuebao, 2022 Objective To investigate the effect of Th1/Th2 ratio on pyroptosis of placental trophoblast cells in early-onset severe preeclampsia. Methods The clinical data of 55 cases of early-onset severe preeclampsia diagnosed in our hospital from June 2018 to ...
WANG Haijiao +5 more
doaj +1 more source
Clinical and Translational Medicine, 2022 Backgrounds Inflammation underlies the mechanism of different kinds of heart disease. Cytoplasmic membrane localized N‐terminal fragment of gasdermin‐D (GSDMD‐N) could induce inflammatory injury to cardiomyocyte.
Ziqing Yu +11 more
doaj +1 more source
Journal of Inflammation Research, 2021 Ding Wang,1,* Xi Zhan,1,* Rui Wu,2 Yan You,3 Weixian Chen,1 Liang Duan1 1Department of Laboratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2Department of Laboratory Medicine,
Wang D +5 more
doaj
Pyroptosis in NLRP3 inflammasome-related atherosclerosis
Cell Stress, 2022 Pyroptosis is a proinflammatory form of programmed cell death in response to inflammation. It involves in the pathogenesis and outcomes of atherosclerosis characterized by NLRP3 inflammasome assembly, membrane pore formation, cell swelling, pro ...
Xiang Zeng +5 more
doaj +1 more source
Gasdermins: novel mitochondrial pore-forming proteins
Molecular & Cellular Oncology, 2019 Gasdermin proteins have been extensively characterized for their ability to form necrotic pores in the plasma membrane, however, their interactions with other organelles have yet to be described.
Corey Rogers, Emad S. Alnemri
doaj +1 more source
Mediators of Inflammation, 2022 The adipose tissue NLRP3 inflammasome has recently emerged as a contributor to obesity-related metabolic inflammation. Recent studies have demonstrated that the activation of the NLRP3 inflammasome cleaves gasdermin D (GSDMD) and induces pyroptosis, a ...
Eun Bi Ma +4 more
doaj +1 more source