Results 21 to 30 of about 13,805 (203)
Journal of Inflammation Research, 2021 Jing Zhang,* Yiqin Dai,* Yujing Yang, Jianjiang Xu Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University; Shanghai Key Laboratory of Visual Impairment and Restoration; NHC Key Laboratory of Myopia, Fudan University ...
Zhang J, Dai Y, Yang Y, Xu J
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Role of Pyroptosis in Diabetes and Its Therapeutic Implications
Journal of Inflammation Research, 2021 Abdullah Al Mamun,1 Yanqing Wu,2 Fatema Nasrin,3,4 Afroza Akter,5 Masuma Afrin Taniya,6 Fahad Munir,7 Chang Jia,8 Jian Xiao1 1Department of Hand Surgery and Peripheral Neurosurgery, The First Affiliated Hospital and School of Pharmaceutical Sciences ...
Al Mamun A +7 more
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Journal of Inflammation Research, 2021 Ding Wang,1,* Xi Zhan,1,* Rui Wu,2 Yan You,3 Weixian Chen,1 Liang Duan1 1Department of Laboratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2Department of Laboratory Medicine,
Wang D +5 more
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Ion Man: GSDMD Punches Pores to Knock Out cGAS [PDF]
Immunity, 2018 The pore-forming protein GSDMD promotes cytokine release and induces pyroptotic cell death. In this issue of Immunity, Banerjee et al. (2018) document how GSDMD triggers potassium efflux to inhibit cGAS-STING and prevent damaging interferon production after bacterial infection.
Rebecca, Feltham, James E, Vince
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Gasdermins: novel mitochondrial pore-forming proteins
Molecular & Cellular Oncology, 2019 Gasdermin proteins have been extensively characterized for their ability to form necrotic pores in the plasma membrane, however, their interactions with other organelles have yet to be described.
Corey Rogers, Emad S. Alnemri
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GSDMD-mediated pyroptosis promotes cardiac remodeling in pressure overload
Clinical and Experimental Hypertension, 2023 Gasdermin D (GSDMD) forms membrane pores to execute pyroptosis. But the mechanism of how cardiomyocyte pyroptosis induces cardiac remodeling in pressure overload remains unclear. We investigated the role of GSDMD-mediated pyroptosis in the pathogenesis of cardiac remodeling in pressure overload.Wild-type (WT) and cardiomyocyte-specific GSDMD-deficient (
Jieyun You +5 more
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Snapshot of a Deadly Embrace: The Caspase-1-GSDMD Interface [PDF]
Immunity, 2020 Proteolytic maturation of the pore-forming protein gasdermin D (GSDMD) by inflammasome-activated caspase-1 is crucial for initiating pyroptosis, a lytic form of cell death. In this issue of Immunity, Lui et al. report the X-ray structure of the caspase-1-GSDMD complex, mapping the interaction interfaces that determine recognition and cleavage of GSDMD ...
Lieselotte, Vande Walle +1 more
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Gasdermin D–mediated pyroptosis suppresses liver regeneration after 70% partial hepatectomy
Hepatology Communications, 2022 Pyroptosis is a kind of programmed cell death primarily mediated by gasdermin D (GSDMD) and shown to regulate multiple diseases. However, its contribution to liver regeneration, a fine‐tuned tissue repair process mediated primarily by hepatocytes after ...
Xingyu Lv +8 more
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Ecotoxicology and Environmental Safety, 2023 Aim: We investigate the mechanism whereby chlorpyrifos (CHI), an environmental toxin, causes liver injury by inducing ferroptosis in hepatocytes. Methods: The toxic dose (LD50 = 50 μM) of CHI for inducing AML12 injury in normal mouse hepatocytes was ...
Chenyang Han +8 more
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Di-san junyi daxue xuebao, 2022 Objective To investigate the effect of Th1/Th2 ratio on pyroptosis of placental trophoblast cells in early-onset severe preeclampsia. Methods The clinical data of 55 cases of early-onset severe preeclampsia diagnosed in our hospital from June 2018 to ...
WANG Haijiao +5 more
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