Results 21 to 30 of about 14,672 (225)

GSDMD Deficiency Protects Against Aortic Rupture [PDF]

, 2021
ABSTRACT Objective Aortic ruptures are fatal consequences of aortic aneurysms with macrophage accumulation being a hallmark at the site of ruptures. Pyroptosis is critical in macrophage-mediated inflammation.
Dien Ye, Deborah A. Howatt, Zhenyu Li, Alan Daugherty, Hong S. Lu, Congqing Wu   +5 more
openaire   +1 more source

Development of diagnostic and prognostic biomarker models for knee osteoarthritis based on NLRP3 inflammasome activation [PDF]

Journal of Medical Biochemistry
Background: This study aimed to characterize the expression profiles of the NOD-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome and its downstream effectors [Interleukin (IL)-1b, IL-18, and Gasdermin-D (GSDMD)] in degenerative knee ...
Xiong Shui, Zhou Junxin, Dong Yuying, Long Ling, Deng Gaorong   +4 more
doaj   +1 more source

Calcitriol Alleviates Hyperosmotic Stress-Induced Corneal Epithelial Cell Damage via Inhibiting the NLRP3–ASC–Caspase-1–GSDMD Pyroptosis Pathway in Dry Eye Disease

Journal of Inflammation Research, 2021
Jing Zhang,* Yiqin Dai,* Yujing Yang, Jianjiang Xu Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University; Shanghai Key Laboratory of Visual Impairment and Restoration; NHC Key Laboratory of Myopia, Fudan University ...
Zhang J, Dai Y, Yang Y, Xu J
doaj  

Gasdermin D Deficiency Does Not Protect Mice from High-Fat Diet-Induced Glucose Intolerance and Adipose Tissue Inflammation

Mediators of Inflammation, 2022
The adipose tissue NLRP3 inflammasome has recently emerged as a contributor to obesity-related metabolic inflammation. Recent studies have demonstrated that the activation of the NLRP3 inflammasome cleaves gasdermin D (GSDMD) and induces pyroptosis, a ...
Eun Bi Ma, Hafiz Muhammad Ahmad Javaid, Do-Hyeon Jung, Jong-Hwan Park, Joo Young Huh   +4 more
doaj   +1 more source

Gasdermin D (GSDMD) as a new target for the treatment of infection [PDF]

MedChemComm, 2019
Inhibition of pyroptosis through targeting the activation or pore-formation of GSDMD.
Ankit Pandeya, Lan Li, Zhenyu Li, Yinan Wei   +3 more
openaire   +2 more sources

Role of Pyroptosis in Diabetes and Its Therapeutic Implications

Journal of Inflammation Research, 2021
Abdullah Al Mamun,1 Yanqing Wu,2 Fatema Nasrin,3,4 Afroza Akter,5 Masuma Afrin Taniya,6 Fahad Munir,7 Chang Jia,8 Jian Xiao1 1Department of Hand Surgery and Peripheral Neurosurgery, The First Affiliated Hospital and School of Pharmaceutical Sciences ...
Al Mamun A, Wu Y, Nasrin F, Akter A, Taniya MA, Munir F, Jia C, Xiao J   +7 more
doaj  

Pyroptosis in NLRP3 inflammasome-related atherosclerosis

Cell Stress, 2022
Pyroptosis is a proinflammatory form of programmed cell death in response to inflammation. It involves in the pathogenesis and outcomes of atherosclerosis characterized by NLRP3 inflammasome assembly, membrane pore formation, cell swelling, pro ...
Xiang Zeng, Dongling Liu, Xia Huo, Yue Wu, Cuiqing Liu, Qinghua Sun   +5 more
doaj   +1 more source

Assessment of Pyroptosis-Related Indicators as Potential Biomarkers and Their Association with Severity in Patients with Liver Cirrhosis

Journal of Inflammation Research, 2021
Ding Wang,1,* Xi Zhan,1,* Rui Wu,2 Yan You,3 Weixian Chen,1 Liang Duan1 1Department of Laboratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2Department of Laboratory Medicine,
Wang D, Zhan X, Wu R, You Y, Chen W, Duan L   +5 more
doaj  

Gasdermins: novel mitochondrial pore-forming proteins

Molecular & Cellular Oncology, 2019
Gasdermin proteins have been extensively characterized for their ability to form necrotic pores in the plasma membrane, however, their interactions with other organelles have yet to be described.
Corey Rogers, Emad S. Alnemri
doaj   +1 more source

Electrostatic influence on IL-1 transport through the GSDMD pore

Proceedings of the National Academy of Sciences, 2022
Significance Gasdermin D (GSDMD) forms large pores that channel the release of alarmins, including interleukin-1 (IL-1) family cytokines, from living cells. IL-1 is synthesized as an inactive cytosolic precursor known as pro-IL-1, which is proteolytically processed into the active mature IL-1 in response to inflammasome activation or ...
Xie, Wen Jun, Xia, Shiyu, Warshel, Arieh, Wu, Hao   +3 more
openaire   +2 more sources