Results 31 to 40 of about 17,882 (284)

GSDMD Deficiency Protects Against Aortic Rupture [PDF]

, 2021
ABSTRACT Objective Aortic ruptures are fatal consequences of aortic aneurysms with macrophage accumulation being a hallmark at the site of ruptures. Pyroptosis is critical in macrophage-mediated inflammation.
Dien Ye, Deborah A. Howatt, Zhenyu Li, Alan Daugherty, Hong S. Lu, Congqing Wu   +5 more
openaire   +1 more source

Calcitriol Alleviates Hyperosmotic Stress-Induced Corneal Epithelial Cell Damage via Inhibiting the NLRP3–ASC–Caspase-1–GSDMD Pyroptosis Pathway in Dry Eye Disease

Journal of Inflammation Research, 2021
Jing Zhang,* Yiqin Dai,* Yujing Yang, Jianjiang Xu Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University; Shanghai Key Laboratory of Visual Impairment and Restoration; NHC Key Laboratory of Myopia, Fudan University ...
Zhang J, Dai Y, Yang Y, Xu J
doaj  

Role of Pyroptosis in Diabetes and Its Therapeutic Implications

Journal of Inflammation Research, 2021
Abdullah Al Mamun,1 Yanqing Wu,2 Fatema Nasrin,3,4 Afroza Akter,5 Masuma Afrin Taniya,6 Fahad Munir,7 Chang Jia,8 Jian Xiao1 1Department of Hand Surgery and Peripheral Neurosurgery, The First Affiliated Hospital and School of Pharmaceutical Sciences ...
Al Mamun A, Wu Y, Nasrin F, Akter A, Taniya MA, Munir F, Jia C, Xiao J   +7 more
doaj  

Quercetin effectively improves LPS-induced intestinal inflammation, pyroptosis, and disruption of the barrier function through the TLR4/NF-κB/NLRP3 signaling pathway in vivo and in vitro

Food & Nutrition Research, 2022
Background: Inflammatory bowel diseases are characterized by the alterations of the mucosa and gastrointestinal physiology, and the core of these alterations is endothelial cells.
Hui-Xin Zhang, Ye-Ye Li, Zhong-Jie Liu, Jiu-Feng Wang   +3 more
doaj   +1 more source

Gasdermin D (GSDMD) as a new target for the treatment of infection [PDF]

MedChemComm, 2019
Inhibition of pyroptosis through targeting the activation or pore-formation of GSDMD.
Ankit Pandeya, Lan Li, Zhenyu Li, Yinan Wei   +3 more
openaire   +2 more sources

Acute ocular hypertension induced pyropotosis in rat retinal ganglion cells and protective effect of inhibiting Caspase-1 in rat model

Di-san junyi daxue xuebao, 2022
Objective To investigate the protective effect of pyroptosis and anti-Caspase-1 treatment on retinal ganglion cells (RGCs) in rats with acute ocular hypertension.
SUN Yulin, LIU Ting
doaj   +1 more source

GSDMD gene knockout alleviates hyperoxia-induced hippocampal brain injury in neonatal mice

, 2023
Background: Neonatal hyperoxia exposure is associated with brain injury and poor neurodevelopment outcomes in preterm infants. Our previous studies in neonatal rodent models have shown that hyperoxia stimulates the brain’s inflammasome pathway, leading ...
Bramlett, Helen, Benny, Merline, Wu, Shu, Dietrich, W Dalton, Moreno, Williams Javier, Schmidt, Augusto F, Duncan, Matthew R, Challa, Naga Venkata Divya, Young, Karen, Chen, Shaoyi, Yun, Huijun   +10 more
core   +2 more sources

Electrostatic influence on IL-1 transport through the GSDMD pore

Proceedings of the National Academy of Sciences, 2022
Significance Gasdermin D (GSDMD) forms large pores that channel the release of alarmins, including interleukin-1 (IL-1) family cytokines, from living cells. IL-1 is synthesized as an inactive cytosolic precursor known as pro-IL-1, which is proteolytically processed into the active mature IL-1 in response to inflammasome activation or ...
Xie, Wen Jun, Xia, Shiyu, Warshel, Arieh, Wu, Hao   +3 more
openaire   +2 more sources

Nuclear translocation of Gasdermin D (GSDMD) sensitizes chemotherapy through inhibiting PARP-1 in colorectal cancer

, 2022
Gasdermin D (GSDMD) has recently been identified to play a central role in pyroptosis of monocytes, through its N-terminal effector domain cleaved by activated inflammatory caspases to form pores on cell membrane.
Peng, Xiao
core   +1 more source

Circ-USP9X interacts with EIF4A3 to promote endothelial cell pyroptosis by regulating GSDMD stability in atherosclerosis

Clinical and Experimental Hypertension, 2023
Endothelial pyroptosis is a pathological mechanism of atherosclerosis (AS). Circular RNAs (circRNAs) are vital in AS progression by regulating endothelial cell functions.
Shengkai Xu, Yishan Ge, Xuebin Wang, Wei Yin, Xiaoqing Zhu, Jie Wang, Shigang Qiao   +6 more
doaj   +1 more source