Results 31 to 40 of about 14,672 (225)

Quercetin effectively improves LPS-induced intestinal inflammation, pyroptosis, and disruption of the barrier function through the TLR4/NF-κB/NLRP3 signaling pathway in vivo and in vitro

Food & Nutrition Research, 2022
Background: Inflammatory bowel diseases are characterized by the alterations of the mucosa and gastrointestinal physiology, and the core of these alterations is endothelial cells.
Hui-Xin Zhang, Ye-Ye Li, Zhong-Jie Liu, Jiu-Feng Wang   +3 more
doaj   +1 more source

Acute ocular hypertension induced pyropotosis in rat retinal ganglion cells and protective effect of inhibiting Caspase-1 in rat model

Di-san junyi daxue xuebao, 2022
Objective To investigate the protective effect of pyroptosis and anti-Caspase-1 treatment on retinal ganglion cells (RGCs) in rats with acute ocular hypertension.
SUN Yulin, LIU Ting
doaj   +1 more source

Synoviolin alleviates GSDMD‐mediated periodontitis by suppressing its stability

Immunity, Inflammation and Disease, 2023
AbstractIntroductionInflammasome and pyroptosis play important roles in periodontitis. Gasdermin D (GSDMD), a key factor in pyroptosis, is cleaved by caspase‐1 and regulated by ubiquitination. Synoviolin is a ubiquitin E3 ligase that interacts with GSDMD.
Ying Pang, Lili Liu, Shuainan Wu, Jianqi Wang, Lu Liu   +4 more
openaire   +3 more sources

Gasdermin D Inhibits Coronavirus Infection by Promoting the Noncanonical Secretion of Beta Interferon

mBio, 2022
Pyroptosis, a programmed cell death, functions as an innate immune effector mechanism and plays a crucial role against microbial invasion. Gasdermin D (GSDMD), as the main pyroptosis effector, mediates pyroptosis and promotes releasing proinflammatory ...
Liyuan Zhao, Liang Li, Mei Xue, Xiang Liu, Chengfan Jiang, Wenzhe Wang, Lijie Tang, Li Feng, Pinghuang Liu   +8 more
doaj   +1 more source

Gasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death

Cell Reports, 2018
Summary: Gasdermin D (GSDMD) is considered a proinflammatory factor that mediates pyroptosis in macrophages to protect hosts from intracellular bacteria.
Hiroto Kambara, Fei Liu, Xiaoyu Zhang, Peng Liu, Besnik Bajrami, Yan Teng, Li Zhao, Shiyi Zhou, Hongbo Yu, Weidong Zhou, Leslie E. Silberstein, Tao Cheng, Mingzhe Han, Yuanfu Xu, Hongbo R. Luo   +14 more
doaj   +1 more source

Circ-USP9X interacts with EIF4A3 to promote endothelial cell pyroptosis by regulating GSDMD stability in atherosclerosis

Clinical and Experimental Hypertension, 2023
Endothelial pyroptosis is a pathological mechanism of atherosclerosis (AS). Circular RNAs (circRNAs) are vital in AS progression by regulating endothelial cell functions.
Shengkai Xu, Yishan Ge, Xuebin Wang, Wei Yin, Xiaoqing Zhu, Jie Wang, Shigang Qiao   +6 more
doaj   +1 more source

Gasdermin D protects against Streptococcus equi subsp. zooepidemicus infection through macrophage pyroptosis

Frontiers in Immunology, 2022
Streptococcus equi subsp. zooepidemicus (S. zooepidemicus, SEZ) is an essential zoonotic bacterial pathogen that can cause various inflammation, such as meningitis, endocarditis, and pneumonia. Gasdermin D (GSDMD) is involved in cytokine release and cell
Guobin Xu, Zheng Guo, Yuxuan Liu, Yalin Yang, Yongjin Lin, Chunliu Li, Yunfei Huang, Yunfei Huang, Qiang Fu, Qiang Fu   +9 more
doaj   +1 more source

TR4 worsen urosepsis by regulating GSDMD

European Journal of Medical Research
Abstract Background Urosepsis is a life-threatening organ disease in which pathogenic microorganisms in the urine enter the blood through the vessels, causing an imbalance in the immune response to infection. The aim of this study was to elucidate the role of testicular orphan receptor 4 (TR4) in urosepsis.
Huan Wang, Shibin Zhu, Zhenwei Zhou, Zhenghui Wang, Wei Zhuang, Dingwei Xue, Zeyi Lu, Qiming Zheng, Lifeng Ding, Liangliang Ren, Wenqing Luo, Ruyue Wang, Guangju Ge, Liqun Xia, Gonghui Li, Haiyang Wu   +15 more
openaire   +3 more sources

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Environmental toxin chlorpyrifos induces liver injury by activating P53-mediated ferroptosis via GSDMD-mtROS

Ecotoxicology and Environmental Safety, 2023
Aim: We investigate the mechanism whereby chlorpyrifos (CHI), an environmental toxin, causes liver injury by inducing ferroptosis in hepatocytes. Methods: The toxic dose (LD50 = 50 μM) of CHI for inducing AML12 injury in normal mouse hepatocytes was ...
Chenyang Han, Jian Sheng, Hongyan Pei, Yongjia Sheng, Jin Wang, Xiaohong Zhou, Wenyan Li, Chenxi Cao, Yi Yang   +8 more
doaj   +1 more source