Results 31 to 40 of about 13,805 (203)

Gasdermin D mediates endoplasmic reticulum stress via FAM134B to regulate cardiomyocyte autophagy and apoptosis in doxorubicin-induced cardiotoxicity

Cell Death and Disease, 2022
Cardiomyocyte pyroptosis and apoptosis play a vital role in the pathophysiology of several cardiovascular diseases. Our recent study revealed that gasdermin D (GSDMD) can promote myocardial I/R injury via the caspase-11/GSDMD pathway.
Ya’nan Qu, Rifeng Gao, Xiang Wei, Xiaolei Sun, Kun Yang, Huairui Shi, Yang Gao, Shiyu Hu, Yiwen Wang, Ji’e Yang, Aijun Sun, Feng Zhang, Junbo Ge   +12 more
doaj   +1 more source

Pyroptosis in NLRP3 inflammasome-related atherosclerosis

Cell Stress, 2022
Pyroptosis is a proinflammatory form of programmed cell death in response to inflammation. It involves in the pathogenesis and outcomes of atherosclerosis characterized by NLRP3 inflammasome assembly, membrane pore formation, cell swelling, pro ...
Xiang Zeng, Dongling Liu, Xia Huo, Yue Wu, Cuiqing Liu, Qinghua Sun   +5 more
doaj   +1 more source

Inflammasome-mediated GSDMD activation facilitates escape of Candida albicans from macrophages [PDF]

Nature Communications, 2021
AbstractCandida albicansis the most common cause of fungal sepsis. Inhibition of inflammasome activity confers resistance to polymicrobial and LPS-induced sepsis; however, inflammasome signaling appears to protect againstC. albicansinfection, so inflammasome inhibitors are not clinically useful for candidiasis. Here we show disruption of GSDMD, a known
Xionghui Ding, Hiroto Kambara, Rongxia Guo, Apurva Kanneganti, Maikel Acosta-Zaldívar, Jiajia Li, Fei Liu, Ting Bei, Wanjun Qi, Xuemei Xie, Wenli Han, Ningning Liu, Cunling Zhang, Xiaoyu Zhang, Hongbo Yu, Li Zhao, Fengxia Ma, Julia R. Köhler, Hongbo R. Luo   +18 more
openaire   +3 more sources

Molecular Mechanism of Caspase-8-Dependent Interleukin-18 Activation in Pancreatic Cancer Cells Induced by 5-Fluorouracil and Nutrient Starvation. [PDF]

Genes Cells
Nutrient starvation triggers pyroptosis with cleavage of pro‐IL‐18 and GSDMD in pancreatic cancer cells, and treatment of 5‐FU enhances this process. As a result, active IL‐18 is released and leads to inflammation. ABSTRACT Interleukin‐18 (IL‐18) is a pro‐inflammatory cytokine, and higher IL‐18 expression in pancreatic tumors is associated with poor ...
Kamino H, Nariai Y, Urano T.
europepmc   +2 more sources

Gasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death

Cell Reports, 2018
Summary: Gasdermin D (GSDMD) is considered a proinflammatory factor that mediates pyroptosis in macrophages to protect hosts from intracellular bacteria.
Hiroto Kambara, Fei Liu, Xiaoyu Zhang, Peng Liu, Besnik Bajrami, Yan Teng, Li Zhao, Shiyi Zhou, Hongbo Yu, Weidong Zhou, Leslie E. Silberstein, Tao Cheng, Mingzhe Han, Yuanfu Xu, Hongbo R. Luo   +14 more
doaj   +1 more source

Quercetin effectively improves LPS-induced intestinal inflammation, pyroptosis, and disruption of the barrier function through the TLR4/NF-κB/NLRP3 signaling pathway in vivo and in vitro

Food & Nutrition Research, 2022
Background: Inflammatory bowel diseases are characterized by the alterations of the mucosa and gastrointestinal physiology, and the core of these alterations is endothelial cells.
Hui-Xin Zhang, Ye-Ye Li, Zhong-Jie Liu, Jiu-Feng Wang   +3 more
doaj   +1 more source

Acute ocular hypertension induced pyropotosis in rat retinal ganglion cells and protective effect of inhibiting Caspase-1 in rat model

Di-san junyi daxue xuebao, 2022
Objective To investigate the protective effect of pyroptosis and anti-Caspase-1 treatment on retinal ganglion cells (RGCs) in rats with acute ocular hypertension.
SUN Yulin, LIU Ting
doaj   +1 more source

TR4 worsen urosepsis by regulating GSDMD

European Journal of Medical Research
Abstract Background Urosepsis is a life-threatening organ disease in which pathogenic microorganisms in the urine enter the blood through the vessels, causing an imbalance in the immune response to infection. The aim of this study was to elucidate the role of testicular orphan receptor 4 (TR4) in urosepsis.
Huan Wang, Shibin Zhu, Zhenwei Zhou, Zhenghui Wang, Wei Zhuang, Dingwei Xue, Zeyi Lu, Qiming Zheng, Lifeng Ding, Liangliang Ren, Wenqing Luo, Ruyue Wang, Guangju Ge, Liqun Xia, Gonghui Li, Haiyang Wu   +15 more
openaire   +3 more sources

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Electrostatic influence on IL-1 transport through the GSDMD pore

Proceedings of the National Academy of Sciences, 2022
Significance Gasdermin D (GSDMD) forms large pores that channel the release of alarmins, including interleukin-1 (IL-1) family cytokines, from living cells. IL-1 is synthesized as an inactive cytosolic precursor known as pro-IL-1, which is proteolytically processed into the active mature IL-1 in response to inflammasome activation or other ...
Xie, Wen Jun, Xia, Shiyu, Warshel, Arieh, Wu, Hao   +3 more
openaire   +2 more sources