Results 1 to 10 of about 45,213 (197)
Journal of Experimental Medicine, 2018 In this issue of JEM, Boucher et al. (https://doi.org/10.1084/jem.20172222) report isolation of active caspase-1 from macrophages after inflammasome activation.
Sandstrom, Andrew, VANCE, Russell E.
core +6 more sources
Activation of Nlrp3 inflammasomes enhances macrophage lipid-deposition and migration: implication of a novel role of inflammasome in atherogenesis. [PDF]
PLoS ONE, 2014 Although Nlrp3 inflammasome activation in macrophages has been shown to be critical for the development of atherosclerosis upon atherogenic stimuli, it remains unknown whether activated Nlrp3 inflammasomes by other non-atherogenic stimuli induce ...
Xiang Li +5 more
doaj +11 more sources
Cell, 2010 Inflammasomes are molecular platforms activated upon cellular infection or stress that trigger the maturation of proinflammatory cytokines such as interleukin-1beta to engage innate immune defenses. Strong associations between dysregulated inflammasome activity and human heritable and acquired inflammatory diseases highlight the importance this pathway
Assoc Prof Kate Schroder
exaly +4 more sources
Antiviral Inflammasomes and How to Find Them [PDF]
VirusesInflammasomes are signaling complexes of the innate immune system that are assembled in distinct sentinel cell types to coordinate inflammation. As demonstrated by the emergence of viral antagonists and evasion mechanisms, inflammasomes are critical to ...
Jennifer Deborah Wuerth +1 more
doaj +2 more sources
Inflammasomes and pyroptosis in cancer: mechanisms and therapeutic advances [PDF]
Journal of Hematology & OncologyInflammasomes are being increasingly recognized for their critical roles in regulating immune cell infiltration, antitumor immunity, and tumorigenesis in cancer biology.
Wonhyoung Seo +6 more
doaj +2 more sources
Molecular Aspects of Medicine, 2020 Ketelut-Carneiro and Fitzgerald discuss the basic concepts about inflammasome composition, assembly and activation, effector functions and role in infection and inflammatory disease.
Natália, Ketelut-Carneiro +1 more
openaire +4 more sources
Regulation of cancer by inflammasomes: from inflammation to tumorigenesis [PDF]
Frontiers in ImmunologyInflammation is closely linked to the development and progression of cancer, as well as the effectiveness of cancer treatment. Inflammation is an immune response triggered when the immune system detects harmful stimuli such as pathogens, damaged cells ...
Shivani Malvankar +3 more
doaj +2 more sources
Inflammasomes cross-talk with lymphocytes to connect the innate and adaptive immune response
Journal of Advanced Research, 2023 Background: Innate and adaptive immunity are two different parts of the immune system that have different characteristics and work together to provide immune protection. Inflammasomes are a major part of the innate immune system that are expressed widely
Hongliang Zhang +4 more
doaj +1 more source
Roles of inflammasomes in viral myocarditis
Frontiers in Cellular and Infection Microbiology, 2023 Viral myocarditis (VMC), characterized by viral infection-induced inflammation, is a life-threatening disease associated with dilated cardiomyopathy or heart failure.
Jingyu Xu +5 more
doaj +1 more source