Results 1 to 10 of about 35,568 (289)

Inflammasomes: novel therapeutic targets for metabolic syndrome? [PDF]

Frontiers in Endocrinology
Chronic inflammation is a hallmark for Metabolic Syndrome (MetS). It is also one of the most important risk factors for insulin resistance and metabolic disorders.
Pengyu Cao, Pengyu Cao, Yulin Yang, Yulin Yang, Ningning Zhang, Bojian Wang, Zhenwei Gong   +6 more
doaj   +2 more sources

Targeting inflammasomes as an immunotherapeutic strategy for cancer

Journal of Translational Medicine
Inflammasomes are essential regulators of innate immunity, inflammation, and cellular apoptosis, and they have surfaced as significant modulators of cancer progression and regulation.
Luanluan Huang, Xiaoyan Chen, Ruiqi Liu, Ding Nan, Wenxuan Bao, Lixian Yang, Xiaomeng Dai, Jianming Tang, Haibo Zhang, Yanwei Lu   +9 more
doaj   +2 more sources

Bacterial exotoxins and the inflammasome [PDF]

Frontiers in Immunology, 2015
The inflammasomes are intracellular protein complexes that play an important role in innate immune sensing. Activation of inflammasomes leads to activation of caspase-1 and maturation and secretion of the pro-inflammatory cytokines IL-1β and IL-18.
Allison J. Greaney, Stephen H. Leppla, Mahtab eMoayeri   +2 more
doaj   +3 more sources

Pyroptosis: a new insight into intestinal inflammation and cancer

Frontiers in Immunology
Pyroptosis is an innate immune response triggered by the activation of inflammasomes by various influencing factors, characterized by cell destruction. It impacts the immune system and cancer immunotherapy.
Limin Chao, Wenjing Zhang, Yuchao Feng, Pei Gao, Jinyou Ma   +4 more
doaj   +1 more source

Changes in expression of NLRP3 inflamasome and IL-1β in the development of oxazolone-induced colitis in rats and on the background of administration of simvastatin and interleukin-1β receptor antagonist

Patologìâ, 2021
The aim. To study the expression of mRNA of the NLRP3 inflammasome and proinflammatory cytokine IL-1β in the inflamed colon of rats with experimental oxazolone-induced colitis and against the background of the introduction of simvastatin and antagonist ...
O. S. Zherebiatiev, N. M. Polishchuk
doaj   +1 more source

Nanobodies dismantle post‐pyroptotic ASC specks and counteract inflammation in vivo

EMBO Molecular Medicine, 2022
Inflammasomes sense intracellular clues of infection, damage, or metabolic imbalances. Activated inflammasome sensors polymerize the adaptor ASC into micron‐sized “specks” to maximize caspase‐1 activation and the maturation of IL‐1 cytokines.
Damien Bertheloot, Carlos WS Wanderley, Ayda H Schneider, Lisa DJ Schiffelers, Jennifer D Wuerth, Jan MP Tödtmann, Salie Maasewerd, Ibrahim Hawwari, Fraser Duthie, Cornelia Rohland, Lucas S Ribeiro, Lea‐Marie Jenster, Nathalia Rosero, Yonas M Tesfamariam, Fernando Q Cunha, Florian I Schmidt, Bernardo S Franklin   +16 more
doaj   +1 more source

Inflammasomes driven inflammation in lung cancer revisited: a short review

Exploration of Immunology, 2023
Lung cancer is the leading cause of cancer-related deaths worldwide. The main risk factor for lung cancer is exposure to chemicals present in cigarettes and atmospheric pollutants, which, among other mechanisms, can increase the risk of cancer by ...
Vitor Rodrigues da Costa, Olívia Fonseca Souza, Michelli Ramires Teixeira, Anderson Lucas Alievi, Hugo Vigerelli, Rodrigo Pinheiro Araldi   +5 more
doaj   +1 more source

Biomaterials Functionalized with Inflammasome Inhibitors—Premises and Perspectives

Journal of Functional Biomaterials
This review aimed at searching literature for data regarding the inflammasomes’ involvement in the pathogenesis of oral diseases (mainly periodontitis) and general pathologies, including approaches to control inflammasome-related pathogenic mechanisms ...
Norina Vinţeler, Claudia Nicoleta Feurdean, Regina Petkes, Reka Barabas, Bianca Adina Boşca, Alexandrina Muntean, Dana Feștilă, Aranka Ilea   +7 more
doaj   +1 more source

Caspase-1 interdomain linker cleavage is required for pyroptosis

Life Science Alliance, 2020
The related human NLRP1 and CARD8 form ASC-dependent and ASC-independent inflammasomes, respectively, both of which require pro-caspase-1 interdomain linker processing for the induction of pyroptosis. Pathogen-related signals induce a number of cytosolic
Daniel P Ball, Cornelius Y Taabazuing, Andrew R Griswold, Elizabeth L Orth, Sahana D Rao, Ilana B Kotliar, Lauren E Vostal, Darren C Johnson, Daniel A Bachovchin   +8 more
doaj   +1 more source

Mitochondrial dysfunction induces NLRP3 inflammasome activation during cerebral ischemia/reperfusion injury

Journal of Neuroinflammation, 2018
Background Nod-like receptor protein 3 (NLRP3) inflammasome is a crucial factor in mediating inflammatory responses after cerebral ischemia/reperfusion (I/R), but the cellular location of NLRP3 inflammasome in cerebral I/R has yet come to a conclusion ...
Zhe Gong, Jingrui Pan, Qingyu Shen, Mei Li, Ying Peng   +4 more
doaj   +1 more source