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Inflammasomes as Targets for Adjuvants
Pathogens, 2020 Inflammasomes are an essential part of the innate immune system. They are necessary for the development of a healthy immune response against infectious diseases.
Konstantin Ivanov +2 more
exaly +5 more sources
Inflammasomes and Colorectal Cancer
Cells, 2021 Inflammasomes are important intracellular multiprotein signaling complexes that modulate the activation of caspase-1 and induce levels of the proinflammatory cytokines interleukin-1β (IL-1β) and IL-18 in response to pathogenic microorganisms and ...
Sanaz Keshavarz Shahbaz +5 more
doaj +2 more sources
The roles of inflammasomes in cancer [PDF]
Frontiers in Immunology, 2023 Inflammation is a key characteristic of all stages of tumor development, including tumor initiation, progression, malignant transformation, invasion, and metastasis.
Zihan Deng +5 more
doaj +2 more sources
Inflammasomes cross-talk with lymphocytes to connect the innate and adaptive immune response
Journal of Advanced Research, 2023 Background: Innate and adaptive immunity are two different parts of the immune system that have different characteristics and work together to provide immune protection. Inflammasomes are a major part of the innate immune system that are expressed widely
Hongliang Zhang +4 more
doaj +2 more sources
Antiviral Inflammasomes and How to Find Them [PDF]
VirusesInflammasomes are signaling complexes of the innate immune system that are assembled in distinct sentinel cell types to coordinate inflammation. As demonstrated by the emergence of viral antagonists and evasion mechanisms, inflammasomes are critical to ...
Jennifer Deborah Wuerth +1 more
doaj +2 more sources
Roles of inflammasomes in viral myocarditis
Frontiers in Cellular and Infection Microbiology, 2023 Viral myocarditis (VMC), characterized by viral infection-induced inflammation, is a life-threatening disease associated with dilated cardiomyopathy or heart failure.
Jingyu Xu +5 more
doaj +1 more source
Emerging Roles of Inflammasomes in Cardiovascular Diseases
Frontiers in Immunology, 2022 Cardiovascular diseases are known as the leading cause of morbidity and mortality worldwide. As an innate immune signaling complex, inflammasomes can be activated by various cardiovascular risk factors and regulate the activation of caspase-1 and the ...
Yingnan Liao, Kui Liu, Liyuan Zhu
doaj +1 more source
Updating the NLRC4 Inflammasome: from Bacterial Infections to Autoimmunity and Cancer
Frontiers in Immunology, 2021 Inflammasomes comprise a family of cytosolic multi-protein complexes that modulate the activation of cysteine-aspartate-specific protease 1 (caspase-1) and promote the maturation and secretion of interleukin (IL)-1β and IL-18, leading to an inflammatory ...
Jiexia Wen +8 more
doaj +1 more source
Involvement of inflammasomes in tumor microenvironment and tumor therapies
Journal of Hematology & Oncology, 2023 Inflammasomes are macromolecular platforms formed in response to damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns, whose formation would cause maturation of interleukin-1 (IL-1) family members and gasdermin D (GSDMD)
Ziqi Zhang +4 more
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