Results 31 to 40 of about 30,720 (259)
Inflammasome activation by viral infection: mechanisms of activation and regulation
Frontiers in Microbiology, 2023 Viral diseases are the most common problems threatening human health, livestock, and poultry industries worldwide. Viral infection is a complex and competitive dynamic biological process between a virus and a host/target cell.
Wen Shi +14 more
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Complementing the inflammasome [PDF]
Immunology, 2016 SummaryThe innate immune system is an ancient surveillance system able to sense microbial invaders as well as aberrations in normal cell function. No longer viewed as a static and non‐specific part of immunity, the innate immune system employs a plethora of specialized pattern recognition sensors to monitor and achieve homeostasis; these include the ...
Martha, Triantafilou +3 more
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Emerging mechanisms and functions of inflammasome complexes in teleost fish
Frontiers in Immunology, 2023 Inflammasomes are multiprotein complexes, which are assembled in response to a diverse range of exogenous pathogens and endogenous danger signals, leading to produce pro-inflammatory cytokines and induce pyroptotic cell death.
Ming Xian Chang +2 more
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Journal of Experimental Medicine, 2018 In this issue of JEM, Boucher et al. (https://doi.org/10.1084/jem.20172222) report isolation of active caspase-1 from macrophages after inflammasome activation. Surprisingly, they find that caspase-1 is quickly inactivated upon autoproteolytic processing.
Sandstrom, Andrew, Vance, Russell E
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Molecular Aspects of Medicine, 2022 Two decades of inflammasome research has led to a vast body of knowledge on the complex regulatory mechanisms and pathological roles of canonical and non-canonical inflammasome activation in a plethora of research models of primarily rodent origin. More recently, the field has made notable progress in characterizing human-specific inflammasomes and ...
Paerewijck, Oonagh, Lamkanfi, Mohamed
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Frontiers in Cellular Neuroscience, 2022 Recombinant human erythropoietin (rhEPO) has been shown to exert anti-apoptotic and anti-inflammatory effects after cerebral ischemia. Inflammatory cytokines interleukin-1β and -18 (IL-1β and IL-18) are crucial mediators of apoptosis and are maturated by
Eren Arik +11 more
doaj +1 more source
Inflammasomes and Their Activation [PDF]
Critical Reviews™ in Immunology, 2010 The innate immune system relies on the recognition of pathogens by pattern recognition receptors as a first line of defense and to initiate the adaptive immune response. Substantial progress has been made in defining the role of Nod (nucleotide-binding oligimerization domain)-like receptors and AIM2 (absent in melanoma 2) as pattern recognition ...
Sonal, Khare +3 more
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Anthrax and the inflammasome [PDF]
Microbes and Infection, 2012 Anthrax lethal toxin (LT), a major virulence determinant of anthrax disease, induces vascular collapse in mice and rats. LT activates the Nlrp1 inflammasome in macrophages and dendritic cells, resulting in caspase-1 activation, IL-1β and IL-18 maturation and a rapid cell death (pyroptosis).
Mahtab, Moayeri +2 more
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Inflammasomes: Role in disease pathogenesis and therapeutic potential
Учёные записки Казанского университета: Серия Естественные науки, 2020 The structure of inflammasomes, history of their discovery, and their potential use as therapeutic targets were discussed. Inflammasomes represent cytosolic polyprotein complexes that are formed in response to various external and internal stimuli ...
E.E. Garanina +4 more
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Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source