Results 31 to 40 of about 35,568 (289)
Involvement of inflammasomes in tumor microenvironment and tumor therapies
Journal of Hematology & Oncology, 2023 Inflammasomes are macromolecular platforms formed in response to damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns, whose formation would cause maturation of interleukin-1 (IL-1) family members and gasdermin D (GSDMD)
Ziqi Zhang +4 more
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Inflammasomes and Fibrosis [PDF]
Frontiers in Immunology, 2021 Fibrosis is the final common pathway of inflammatory diseases in various organs. The inflammasomes play an important role in the progression of fibrosis as innate immune receptors. There are four main members of the inflammasomes, such as NOD-like receptor protein 1 (NLRP1), NOD-like receptor protein 3 (NLRP3), NOD-like receptor C4 (NLRC4), and absent ...
Wen-Juan Zhang +5 more
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Molecules, 2021 In recent years, the interplay between the activation of the immune system, the development of chronic inflammation and the onset and progression of many different diseases has been studied extensively [...]
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Frontiers in Immunology, 2022 BackgroundThe absent in melanoma 2 (AIM2) inflammasome is a multi-protein platform that recognizes aberrant cytoplasmic double-stranded DNA(dsDNA) and induces cytokine maturation, release, and pyroptosis. Some studies found that the AIM2 inflammasome was
Yan Qin +8 more
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Inflammasomes in the Intestinal Epithelium [PDF]
, 2023 Inflammasomes are multiprotein signalling complexes that detect a diverse range of pathological stimuli to activate inflammatory caspases, resulting in cell death and the release of IL-18 and IL-1. Inflammasomes are important in a wide range of diseases,
Bruce, Jessica
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Activation of Nlrp3 inflammasomes enhances macrophage lipid-deposition and migration: implication of a novel role of inflammasome in atherogenesis. [PDF]
PLoS ONE, 2014 Although Nlrp3 inflammasome activation in macrophages has been shown to be critical for the development of atherosclerosis upon atherogenic stimuli, it remains unknown whether activated Nlrp3 inflammasomes by other non-atherogenic stimuli induce ...
Xiang Li +5 more
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Exploring Inflammasome Complex as a Therapeutic Approach in Inflammatory Diseases
Future Pharmacology, 2023 Inflammasomes, a group of multiprotein complexes, are essential in regulating inflammation and immune responses. Several inflammasomes, including nucleotide-binding domain leucine-rich repeat-containing protein 1 (NLRP1), NLRP3, NLRP6, NLRP7, NLRP12 ...
Sharmim Sultana +7 more
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ASC filament formation serves as a signal amplification mechanism for inflammasomes [PDF]
, 2016 A hallmark of inflammasome activation is the ASC speck, a micrometre-sized structure formed by the inflammasome adaptor protein ASC (apoptosis-associated speck-like protein containing a CARD), which consists of a pyrin domain (PYD) and a caspase ...
Hiller, Sebastian +4 more
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Inflammasomes and Atherosclerosis [PDF]
, 2016 Inflammation plays an important role in atherosclerosis. Inflammasomes play a crucial role in innate immunity, which mediates the body’s response to various pathogens.
J. L. Mehta, S. Vallurupalli, Yao Dai
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Of inflammasomes and pathogens – sensing of microbes by the inflammasome
EMBO Molecular Medicine, 2013 Abstract Inflammasomes are signalling platforms that sense a diverse range of microbial products and also a number of stress and damage associated endogenous signals. Inflammasome complexes can be formed by members of the Nod‐like receptor family or the PYHIN family member AIM2.
Franz Bauernfeind, Veit Hornung
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