Results 11 to 20 of about 36,611 (292)
Cell, 2010 Inflammasomes are molecular platforms activated upon cellular infection or stress that trigger the maturation of proinflammatory cytokines such as interleukin-1β to engage innate immune defenses.
Kate Schroder +7 more
core +7 more sources
Inflammasomes, the eye and anti-inflammasome therapy [PDF]
Eye, 2018 Inflammasomes, key molecular regulators that play an important role in inflammation, consist of a central protein, an adaptor protein ASC (apoptosis speck-like protein) and a caspase-1 protein.
Yerramothu, P +2 more
core +5 more sources
Immunology, 2021 Inflammasomes are generally thought of as large protein complexes that assemble in the cytosol in response to danger such as tissue damage or infection; once activated, they trigger production of inflammatory cytokines and drive cells towards a pro ...
Kathy Triantafilou, Triantafilou, Kathy
core +4 more sources
The interaction of inflammasomes and gut microbiota: novel therapeutic insights
Cell Communication and SignalingInflammasomes are complex platforms for the cleavage and release of inactivated IL-1β and IL-18 cytokines that trigger inflammatory responses against damage-associated molecular patterns (DAMPs) or pathogen-associated molecular patterns (PAMPs).
Shirin Manshouri +5 more
doaj +2 more sources
Inflammasomes: novel therapeutic targets for metabolic syndrome? [PDF]
Frontiers in EndocrinologyChronic inflammation is a hallmark for Metabolic Syndrome (MetS). It is also one of the most important risk factors for insulin resistance and metabolic disorders.
Pengyu Cao +6 more
doaj +2 more sources
Mechanism of inflammasomes in cancer and targeted therapies [PDF]
Frontiers in Oncology, 2023 Inflammasomes, composed of the nucleotide-binding oligomerization domain(NOD)-like receptors (NLRs), are immune-functional protein multimers that are closely linked to the host defense mechanism.
Qingdan Gu +3 more
doaj +2 more sources
Inflammasomes: Role in disease pathogenesis and therapeutic potential
Учёные записки Казанского университета: Серия Естественные науки, 2020 The structure of inflammasomes, history of their discovery, and their potential use as therapeutic targets were discussed. Inflammasomes represent cytosolic polyprotein complexes that are formed in response to various external and internal stimuli ...
E.E. Garanina +4 more
doaj +3 more sources
Role of inflammasomes in Toxoplasma and Plasmodium infections
Parasites & VectorsBackground The detection of pathogen-associated molecular patterns (PAMPs) or damage-associated molecular patterns (DAMPs) by multimeric protein complexes, known as inflammasomes, triggers an inflammatory response, which is a critical component of the ...
Zhi-xin Wang +4 more
doaj +2 more sources
Inflammasomes as regulators of mechano-immunity [PDF]
EMBO Reports, 2023 Mechano-immunity, the intersection between cellular or tissue mechanics and immune cell function, is emerging as an important factor in many inflammatory diseases. Mechano-sensing defines how cells detect mechanical changes in their environment.
Jelena S Bezbradica, Clare E Bryant
doaj +3 more sources
Inflammasomes in Tissue Damages and Immune Disorders After Trauma [PDF]
Frontiers in Immunology, 2018 Trauma remains a leading cause of death worldwide. Hemorrhagic shock and direct injury to vital organs are responsible for early mortality whereas most delayed deaths are secondary to complex pathophysiological processes.
Perrine Bortolotti +3 more
doaj +2 more sources