Results 11 to 20 of about 35,568 (289)

Inflammasomes as Targets for Adjuvants

Pathogens, 2020
Inflammasomes are an essential part of the innate immune system. They are necessary for the development of a healthy immune response against infectious diseases.
Konstantin Ivanov, Albert Rizvanov
exaly   +5 more sources

Antiviral Inflammasomes and How to Find Them [PDF]

Viruses
Inflammasomes are signaling complexes of the innate immune system that are assembled in distinct sentinel cell types to coordinate inflammation. As demonstrated by the emergence of viral antagonists and evasion mechanisms, inflammasomes are critical to ...
Jennifer Deborah Wuerth, Florian Ingo Schmidt   +1 more
doaj   +3 more sources

The Inflammasomes [PDF]

PLoS Pathogens, 2009
Vishva Dixit, Mohamed Lamkanfi
exaly   +5 more sources

Inflammasomes and Colorectal Cancer

Cells, 2021
Inflammasomes are important intracellular multiprotein signaling complexes that modulate the activation of caspase-1 and induce levels of the proinflammatory cytokines interleukin-1β (IL-1β) and IL-18 in response to pathogenic microorganisms and ...
Sanaz Keshavarz Shahbaz, Khadijeh Koushki, Seyed Hassan Ayati, Abigail R. Bland, Evgeny E. Bezsonov, Amirhossein Sahebkar   +5 more
doaj   +2 more sources

The roles of inflammasomes in cancer [PDF]

Frontiers in Immunology, 2023
Inflammation is a key characteristic of all stages of tumor development, including tumor initiation, progression, malignant transformation, invasion, and metastasis.
Zihan Deng, Lisen Lu, Binghui Li, Xiujuan Shi, Honglin Jin, Weidong Hu   +5 more
doaj   +2 more sources

Enigmatic inflammasomes [PDF]

Immunology, 2021
Inflammasomes are generally thought of as large protein complexes that assemble in the cytosol in response to danger such as tissue damage or infection; once activated, they trigger production of inflammatory cytokines and drive cells towards a pro ...
Kathy Triantafilou, Triantafilou, Kathy
core   +4 more sources

Inflammasomes, the eye and anti-inflammasome therapy [PDF]

Eye, 2018
Inflammasomes, key molecular regulators that play an important role in inflammation, consist of a central protein, an adaptor protein ASC (apoptosis speck-like protein) and a caspase-1 protein.
Yerramothu, P, Vijay, AK ; https://orcid.org/, Willcox, MDP ; https://orcid.org/   +2 more
core   +5 more sources

Dynamic roles of inflammasomes in inflammatory tumor microenvironment

npj Precision Oncology, 2021
The inflammatory tumor microenvironment has been known to be closely connected to all stages of cancer development, including initiation, promotion, and progression.
Jeong-Hoon Jang, Do-Hee Kim, Young-Joon Surh   +2 more
doaj   +2 more sources

Inflammasomes as regulators of mechano-immunity [PDF]

EMBO Reports, 2023
Mechano-immunity, the intersection between cellular or tissue mechanics and immune cell function, is emerging as an important factor in many inflammatory diseases. Mechano-sensing defines how cells detect mechanical changes in their environment.
Jelena S Bezbradica, Clare E Bryant
doaj   +5 more sources

The interaction of inflammasomes and gut microbiota: novel therapeutic insights

Cell Communication and Signaling
Inflammasomes are complex platforms for the cleavage and release of inactivated IL-1β and IL-18 cytokines that trigger inflammatory responses against damage-associated molecular patterns (DAMPs) or pathogen-associated molecular patterns (PAMPs).
Shirin Manshouri, Farhad Seif, Monireh Kamali, Mohammad Ali Bahar, Arshideh Mashayekh, Rasol Molatefi   +5 more
doaj   +2 more sources