Results 11 to 20 of about 45,312 (295)
The roles of inflammasomes in cancer
Frontiers in Immunology, 2023 Inflammation is a key characteristic of all stages of tumor development, including tumor initiation, progression, malignant transformation, invasion, and metastasis.
Zihan Deng +5 more
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Emerging Roles of Inflammasomes in Cardiovascular Diseases
Frontiers in Immunology, 2022 Cardiovascular diseases are known as the leading cause of morbidity and mortality worldwide. As an innate immune signaling complex, inflammasomes can be activated by various cardiovascular risk factors and regulate the activation of caspase-1 and the ...
Yingnan Liao, Kui Liu, Liyuan Zhu
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Inflammasomes and Colorectal Cancer
Cells, 2021 Inflammasomes are important intracellular multiprotein signaling complexes that modulate the activation of caspase-1 and induce levels of the proinflammatory cytokines interleukin-1β (IL-1β) and IL-18 in response to pathogenic microorganisms and ...
Sanaz Keshavarz Shahbaz +5 more
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Cold Spring Harbor Perspectives in Biology, 2014 Inflammasomes are large cytosolic multiprotein complexes that assemble in response to detection of infection- or stress-associated stimuli and lead to the activation of caspase-1-mediated inflammatory responses, including cleavage and unconventional secretion of the leaderless proinflammatory cytokines IL-1β and IL-18, and initiation of an inflammatory
de Zoete, Marcel R +3 more
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Molecules, 2021 In recent years, the interplay between the activation of the immune system, the development of chronic inflammation and the onset and progression of many different diseases has been studied extensively [...]
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Immunology, 2021 SummaryInflammasomes are generally thought of as large protein complexes that assemble in the cytosol in response to danger such as tissue damage or infection; once activated, they trigger production of inflammatory cytokines and drive cells towards a pro‐inflammatory death – termed pyroptosis.
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Updating the NLRC4 Inflammasome: from Bacterial Infections to Autoimmunity and Cancer
Frontiers in Immunology, 2021 Inflammasomes comprise a family of cytosolic multi-protein complexes that modulate the activation of cysteine-aspartate-specific protease 1 (caspase-1) and promote the maturation and secretion of interleukin (IL)-1β and IL-18, leading to an inflammatory ...
Jiexia Wen +8 more
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Involvement of inflammasomes in tumor microenvironment and tumor therapies
Journal of Hematology & Oncology, 2023 Inflammasomes are macromolecular platforms formed in response to damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns, whose formation would cause maturation of interleukin-1 (IL-1) family members and gasdermin D (GSDMD)
Ziqi Zhang +4 more
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Frontiers in Immunology, 2022 BackgroundThe absent in melanoma 2 (AIM2) inflammasome is a multi-protein platform that recognizes aberrant cytoplasmic double-stranded DNA(dsDNA) and induces cytokine maturation, release, and pyroptosis. Some studies found that the AIM2 inflammasome was
Yan Qin +8 more
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Inflammasomes, the eye and anti-inflammasome therapy [PDF]
Eye, 2017 Inflammasomes, key molecular regulators that play an important role in inflammation, consist of a central protein, an adaptor protein ASC (apoptosis speck-like protein) and a caspase-1 protein. Upon activation, caspase-1 induces maturation of cytokines such as interleukin-1β (IL-1β) and interleukin-18 (IL-18).
Yerramothu, P, Vijay, AK, Willcox, MDP
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