Results 41 to 50 of about 36,611 (292)
Journal of Experimental Medicine, 2018 In this issue of JEM, Boucher et al. (https://doi.org/10.1084/jem.20172222) report isolation of active caspase-1 from macrophages after inflammasome activation. Surprisingly, they find that caspase-1 is quickly inactivated upon autoproteolytic processing.
Sandstrom, Andrew, Vance, Russell E
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The AIM2 inflammasome is activated in astrocytes during the late phase of EAE
JCI Insight, 2022 Inflammasomes are a class of innate immune signaling platforms that activate in response to an array of cellular damage and pathogens. Inflammasomes promote inflammation under many circumstances to enhance immunity against pathogens and inflammatory ...
William E. Barclay +8 more
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Inflammasome activation by viral infection: mechanisms of activation and regulation
Frontiers in Microbiology, 2023 Viral diseases are the most common problems threatening human health, livestock, and poultry industries worldwide. Viral infection is a complex and competitive dynamic biological process between a virus and a host/target cell.
Wen Shi +14 more
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, 2011 Inflammasomes are crucial actors of the innate immunity. They consist of cytoplasmic multiprotein complexes controlling the biological activities of the inflammatory cytokines IL-1ß and IL-18.
Martinon, F. +7 more
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Frontiers in Cellular Neuroscience, 2022 Recombinant human erythropoietin (rhEPO) has been shown to exert anti-apoptotic and anti-inflammatory effects after cerebral ischemia. Inflammatory cytokines interleukin-1β and -18 (IL-1β and IL-18) are crucial mediators of apoptosis and are maturated by
Eren Arik +11 more
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Molecular Immunology, 2017 Innate immune responses act as first line defences upon exposure to potentially noxious stimuli. The innate immune system has evolved numerous intracellular and extracellular receptors that undertake surveillance for potentially damaging particulates.
Pinkerton, James W. +9 more
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Inflammasomes in neuroinflammatory and neurodegenerative diseases [PDF]
, 2019 Neuroinflammation and neurodegeneration often result from the aberrant deposition of aggregated host proteins, including amyloid-beta, alpha-synuclein, and prions, that can activate inflammasomes.
Sahana Srinivasan +7 more
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Atheroma and the inflammasome [PDF]
Journal of Nuclear Cardiology, 2015 Atherosclerosis is a ubiquitous disorder that begins in childhood. An autopsy study of 2,876 adolescents and young adults (ages 15-34) who died of external causes found fatty streaks in the aorta of 100% of subjects, and in the right coronary artery in half the subjects. The number and extent of lesions increased with age.
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The crystal-induced activation of NLRP3 inflammasomes in atherosclerosis
Inflammation and Regeneration, 2017 Atherosclerosis is an inflammatory disease, which is accompanied by the deposition of cholesterol-rich lipids and the infiltration of macrophages. Other well-known features of atherosclerotic lesions include the deposition of cholesterol crystals and ...
Tadayoshi Karasawa, Masafumi Takahashi
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Biochemical and microscopic analysis of inflammasome complex formation
, 2019 Inflammasomes are multiprotein signaling platforms responsible for the maturation of pro-IL-1β and pro-IL-18 as well as the induction of an inflammatory cell death termed pyroptosis.
Swacha, Patrycja, +7 more
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