Results 61 to 70 of about 35,568 (289)

Inflammasomes and Their Activation [PDF]

Critical Reviews™ in Immunology, 2010
The innate immune system relies on the recognition of pathogens by pattern recognition receptors as a first line of defense and to initiate the adaptive immune response. Substantial progress has been made in defining the role of Nod (nucleotide-binding oligimerization domain)-like receptors and AIM2 (absent in melanoma 2) as pattern recognition ...
Sonal, Khare, Nancy, Luc, Andrea, Dorfleutner, Christian, Stehlik   +3 more
openaire   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Anthrax and the inflammasome [PDF]

Microbes and Infection, 2012
Anthrax lethal toxin (LT), a major virulence determinant of anthrax disease, induces vascular collapse in mice and rats. LT activates the Nlrp1 inflammasome in macrophages and dendritic cells, resulting in caspase-1 activation, IL-1β and IL-18 maturation and a rapid cell death (pyroptosis).
Mahtab, Moayeri, Inka, Sastalla, Stephen H, Leppla   +2 more
openaire   +2 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Inflammasomes of the intestinal epithelium

, 2015
While the functional importance of inflammasomes in blood-derived cell types is well established, it remains poorly understood how inflammasomes in nonhematopoietic cells contribute to mucosal immunity.
Wolf-Dietrich, Hardt,, Sellin, Mikael E, Sellin, Mikael E., Maloy, Kevin J., Maloy, Kevin J, Sellin, Mikael E.,, Mikael E. Sellin, Maslwowski, Kendle M., Kevin J. Maloy, Wolf-Dietrich Hardt, Maloy, Kevin J.,, Maslowski, Kendle M.,, Maslowski, Kendle M; id_orcid, Hardt, Wolf-Dietrich, Kendle M. Maslowski   +14 more
core   +1 more source

Inflammasomes in neuroinflammatory and neurodegenerative diseases [PDF]

, 2019
Neuroinflammation and neurodegeneration often result from the aberrant deposition of aggregated host proteins, including amyloid-beta, alpha-synuclein, and prions, that can activate inflammasomes.
Sahana Srinivasan, Sofie Voet, Mohamed Lamkanfi, Srinivasan, Sahana, van Loo, Geert, Voet, Sofie, Lamkanfi, Mohamed, Geert van Loo   +7 more
core   +1 more source

Inflammasomes and dermatology [PDF]

Anais Brasileiros de Dermatologia, 2016
Inflammasomes are intracellular multiprotein complexes that comprise part of the innate immune response. Since their definition, inflammasome disorders have been linked to an increasing number of diseases. Autoinflammatory diseases refer to disorders in which local factors lead to the activation of innate immune cells, causing tissue damage when in the
Sá, Daniel Coelho de, Festa Neto, Cyro
openaire   +5 more sources

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

From Inflammation to Prostate Cancer: The Role of Inflammasomes

Advances in Urology, 2016
Inflammation-associated studies entice specific attention due to inflammation’s role in multiple stages of prostate cancer development. However, mechanistic regulation of inflammation inciting prostate cancer remains largely uncharacterized.
Dev Karan, Seema Dubey
doaj   +1 more source

Inflammasomes and Cancer: The Dynamic Role of the Inflammasome in Tumor Development

Frontiers in Immunology, 2017
Chronic Inflammation in tumor microenvironments is not only associated with various stages of tumor development, but also has significant impacts on tumor immunity and immunotherapy.
Melvin Kantono, Melvin Kantono, Beichu Guo, Beichu Guo   +3 more
doaj   +1 more source