Peripheral blood mitochondrial DNA content in relation to circulating metabolites and inflammatory markers: a population study [PDF]
, 2017 Mitochondrial DNA (mtDNA) content might undergo significant changes caused by metabolic derangements, oxidative stress and inflammation that lead to development and progression of cardiovascular diseases.
Brguljan-Hitij, Jana +13 more
core +2 more sources
Inflammasomes and dermatology [PDF]
Anais Brasileiros de Dermatologia, 2016 Inflammasomes are intracellular multiprotein complexes that comprise part of the innate immune response. Since their definition, inflammasome disorders have been linked to an increasing number of diseases. Autoinflammatory diseases refer to disorders in which local factors lead to the activation of innate immune cells, causing tissue damage when in the
Sá, Daniel Coelho de, Festa Neto, Cyro
openaire +5 more sources
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
From Inflammation to Prostate Cancer: The Role of Inflammasomes
Advances in Urology, 2016 Inflammation-associated studies entice specific attention due to inflammation’s role in multiple stages of prostate cancer development. However, mechanistic regulation of inflammation inciting prostate cancer remains largely uncharacterized.
Dev Karan, Seema Dubey
doaj +1 more source
Inflammasomes and their role in innate immunity of Sexually Transmitted Infections
Frontiers in Immunology, 2016 Inflammasomes are multiprotein complexes present in the cytosol as Pattern Recognition Receptors (PRRs) or as sensors of Damage Associated Molecular Patterns (DAMPs).
Vivek Verma +3 more
doaj +1 more source
Inflammasomes as regulators of mechano-immunity
EMBO Reports, 2023 Mechano-immunity, the intersection between cellular or tissue mechanics and immune cell function, is emerging as an important factor in many inflammatory diseases. Mechano-sensing defines how cells detect mechanical changes in their environment.
Jelena S Bezbradica, Clare E Bryant
doaj +1 more source
Lysophosphatidylcholine activates caspase-1 in microglia via a novel pathway involving two inflammasomes. [PDF]
, 2017 Inflammasomes regulate microglial caspase-1 activation and subsequent neuroinflammatory processes in brain pathology. In the present study, we have identified inflammasomes causing caspase-1 activation following stimulation of microglia with ...
Eder, C, Scholz, H
core +1 more source
ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source
The interaction of inflammasomes and gut microbiota: novel therapeutic insights
Cell Communication and SignalingInflammasomes are complex platforms for the cleavage and release of inactivated IL-1β and IL-18 cytokines that trigger inflammatory responses against damage-associated molecular patterns (DAMPs) or pathogen-associated molecular patterns (PAMPs).
Shirin Manshouri +5 more
doaj +1 more source
Reactive oxygen species regulate caspase-11 expression and activation of the non-canonical NLRP3 inflammasome during enteric pathogen infection [PDF]
, 2014 Enteropathogenic and enterohemorrhagic bacterial infections in humans are a severe cause of morbidity and mortality. Although NOD-like receptors (NLRs) NOD2 and NLRP3 have important roles in the generation of protective immune responses to enteric ...
Anand, Paras K +6 more
core +3 more sources