Results 51 to 60 of about 35,568 (289)
Molecular Definition of Inflammasomes
, 2011 Inflammasomes are crucial actors of the innate immunity. They consist of cytoplasmic multiprotein complexes controlling the biological activities of the inflammatory cytokines IL-1ß and IL-18.
Martinon, F. +3 more
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Frontiers in Cellular Neuroscience, 2022 Recombinant human erythropoietin (rhEPO) has been shown to exert anti-apoptotic and anti-inflammatory effects after cerebral ischemia. Inflammatory cytokines interleukin-1β and -18 (IL-1β and IL-18) are crucial mediators of apoptosis and are maturated by
Eren Arik +11 more
doaj +1 more source
, 2016 The cells of the innate immune system continually undergo surveillance of the extracellular milieu to serve as the first line of defense against invading microbial pathogens.
Jing, MK, Idris, A, Mahmud, M
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The NAIP/NLRC4 inflammasomes [PDF]
, 2015 Inflammasomes comprise a family of cytosolic multi-protein complexes that sense infection, or other threats, and initiate inflammation via the recruitment and activation of the Caspase-1 protease.
Vance, Russell E
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Atheroma and the inflammasome [PDF]
Journal of Nuclear Cardiology, 2015 Atherosclerosis is a ubiquitous disorder that begins in childhood. An autopsy study of 2,876 adolescents and young adults (ages 15-34) who died of external causes found fatty streaks in the aorta of 100% of subjects, and in the right coronary artery in half the subjects. The number and extent of lesions increased with age.
openaire +2 more sources
Inflammasomes: Role in disease pathogenesis and therapeutic potential
Учёные записки Казанского университета: Серия Естественные науки, 2020 The structure of inflammasomes, history of their discovery, and their potential use as therapeutic targets were discussed. Inflammasomes represent cytosolic polyprotein complexes that are formed in response to various external and internal stimuli ...
E.E. Garanina +4 more
doaj +1 more source
Biochemical and microscopic analysis of inflammasome complex formation
, 2019 Inflammasomes are multiprotein signaling platforms responsible for the maturation of pro-IL-1β and pro-IL-18 as well as the induction of an inflammatory cell death termed pyroptosis.
Swacha, Patrycja, +7 more
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Reassessing the Evolutionary Importance of Inflammasomes [PDF]
, 2016 Inflammasomes monitor the cytosol for microbial contamination or perturbation, and are thus predicted to provide potent defense against infection. However, the compendium of data from murine infection models suggests that inflammasomes merely delay the ...
Miao, Edward A., Maltez, Vivien I.
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Inflammasomes—New Contributors to Blood Diseases
, 2022 Inflammasomes are intracellular multimeric complexes that cleave the precursors of the IL-1 family of cytokines and various proteins, found predominantly in cells of hematopoietic origin.
Basak, Grzegorz Władysław +3 more
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Mechanism of inflammasomes in cancer and targeted therapies
Frontiers in Oncology, 2023 Inflammasomes, composed of the nucleotide-binding oligomerization domain(NOD)-like receptors (NLRs), are immune-functional protein multimers that are closely linked to the host defense mechanism.
Qingdan Gu +3 more
doaj +1 more source