Results 51 to 60 of about 30,720 (259)
The interaction of inflammasomes and gut microbiota: novel therapeutic insights
Cell Communication and SignalingInflammasomes are complex platforms for the cleavage and release of inactivated IL-1β and IL-18 cytokines that trigger inflammatory responses against damage-associated molecular patterns (DAMPs) or pathogen-associated molecular patterns (PAMPs).
Shirin Manshouri +5 more
doaj +1 more source
Inflammasomes in Tissue Damages and Immune Disorders After Trauma
Frontiers in Immunology, 2018 Trauma remains a leading cause of death worldwide. Hemorrhagic shock and direct injury to vital organs are responsible for early mortality whereas most delayed deaths are secondary to complex pathophysiological processes.
Perrine Bortolotti +3 more
doaj +1 more source
Inflammasomes as regulators of mechano-immunity
EMBO Reports, 2023 Mechano-immunity, the intersection between cellular or tissue mechanics and immune cell function, is emerging as an important factor in many inflammatory diseases. Mechano-sensing defines how cells detect mechanical changes in their environment.
Jelena S Bezbradica, Clare E Bryant
doaj +1 more source
ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source
Inflammasomes: novel therapeutic targets for metabolic syndrome?
Frontiers in EndocrinologyChronic inflammation is a hallmark for Metabolic Syndrome (MetS). It is also one of the most important risk factors for insulin resistance and metabolic disorders.
Pengyu Cao +6 more
doaj +1 more source
The Role of NLRP3 Inflammasomes in Trained Immunity
Frontiers in Bioscience-Landmark, 2023 Inflammasomes are cytosolic multi-protein complexes that play an important role in the innate immune system, inducing cytokine maturation and pyroptosis.
Gilyoung Lee +3 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau +11 more
wiley +1 more source
Role of inflammasomes in Toxoplasma and Plasmodium infections
Parasites & VectorsBackground The detection of pathogen-associated molecular patterns (PAMPs) or damage-associated molecular patterns (DAMPs) by multimeric protein complexes, known as inflammasomes, triggers an inflammatory response, which is a critical component of the ...
Zhi-xin Wang +4 more
doaj +1 more source
Biomaterials Functionalized with Inflammasome Inhibitors—Premises and Perspectives
Journal of Functional BiomaterialsThis review aimed at searching literature for data regarding the inflammasomes’ involvement in the pathogenesis of oral diseases (mainly periodontitis) and general pathologies, including approaches to control inflammasome-related pathogenic mechanisms ...
Norina Vinţeler +7 more
doaj +1 more source
Role of Inflammasomes in Neuroimmune and Neurodegenerative Diseases: A Systematic Review
Mediators of Inflammation, 2018 Inflammasomes are multiprotein complexes that can sense pathogen-associated molecular patterns and damage-associated molecular signals. They are involved in the initiation and development of inflammation via activation of IL-1β and IL-18.
Yue Lang +6 more
doaj +1 more source