Results 11 to 20 of about 13,805 (203)

Crosstalk of HDAC4, PP1, and GSDMD in controlling pyroptosis

Cell Death and Disease
Gasdermin D (GSDMD) functions as a pivotal executor of pyroptosis, eliciting cytokine secretion following cleavage by inflammatory caspases. However, the role of posttranslational modifications (PTMs) in GSDMD-mediated pyroptosis remains largely ...
Weilv Xu, Qiao Jin, Xinyue Li, Danyue Li, Xinyu Fu, Nan Chen, Qian Lv, Yuhua Shi, Suhui He, Lu Dong, Yang Yang, Yuqi Yan, Fushan Shi   +12 more
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Mitochondrial GSDMD Pores DAMPen Pyroptosis [PDF]

Immunity, 2020
Noncanoncial inflammasome activation by cytosolic lipopolysaccharide (LPS) causes pyroptotic cell death facilitated by gasdermin D (GSDMD) pore formation. In this issue of Immunity, Huang et al. describe how cytosolic LPS in endothelial cells does not cause cell death but restrains endothelial cell proliferation.
Katherine C, Barnett, Jenny P-Y, Ting
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Review: the role of GSDMD in sepsis

Inflammation Research, 2022
Gasdermin D (GSDMD) is a cytoplasmic protein that is encoded by the gasdermin family GSDMD gene and is the ultimate executor of pyroptosis. Pyroptosis is a mode of lysis and inflammation that regulates cell death, ultimately leading to cell swelling and rupture.
Shao, Ruifei, Lou, Xiran, Xue, Jinfang, Ning, Deyuan, Chen, Guobing, Jiang, Lihong   +5 more
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GSDMD Deficiency Protects Against Aortic Rupture [PDF]

, 2021
ABSTRACTObjectiveAortic ruptures are fatal consequences of aortic aneurysms with macrophage accumulation being a hallmark at the site of ruptures. Pyroptosis is critical in macrophage-mediated inflammation. This study determined effects of pyroptosis on aortic dilation and rupture using GSDMD deficient mice.Approach and ResultsIn an initial study ...
Dien Ye, Deborah A. Howatt, Zhenyu Li, Alan Daugherty, Hong S. Lu, Congqing Wu   +5 more
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Human polymorphisms in GSDMD alter the inflammatory response [PDF]

Journal of Biological Chemistry, 2020
Exomic studies have demonstrated that innate immune genes exhibit an even higher degree of variation than the majority of other gene families. However, the phenotypic implications of this genetic variation are not well understood, with effects ranging from hypomorphic to silent to hyperfunctioning.
Joseph K. Rathkey, Tsan S. Xiao, Derek W. Abbott   +2 more
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GSDMD-mediated pyroptosis: a critical mechanism of diabetic nephropathy [PDF]

Expert Reviews in Molecular Medicine, 2021
AbstractPyroptosis is a recently identified mechanism of programmed cell death related to Caspase-1 that triggers a series of inflammatory reactions by releasing several proinflammatory factors such as IL-1β and IL-18. The process is characterised by the rupture of cell membranes and the release of cell contents through the mediation of gasdermin (GSDM)
Yi Zuo, Li Chen, Huiping Gu, Xiaoyun He, Zhen Ye, Zhao Wang, Qixiang Shao, Caiping Xue   +7 more
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GSDMD-Mediated Cardiomyocyte Pyroptosis Promotes Myocardial I/R Injury [PDF]

Circulation Research, 2021
Rationale: Pyroptosis is a morphologically and mechanistically distinct form of cell death and is characterized by GSDMD (gasdermin D) or GSDME (gasdermin E)-mediated necrosis with excessive inflammatory factor release. Cardiomyocyte necrosis and inflammation play key roles in the pathophysiology of myocardial ischemia ...
Huairui Shi, Yang Gao, Zhen Dong, Ji’e Yang, Rifeng Gao, Xiao Li, Shuqi Zhang, Leilei Ma, Xiaolei Sun, Zeng Wang, Feng Zhang, Kai Hu, Aijun Sun, Junbo Ge   +13 more
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Synoviolin alleviates GSDMD‐mediated periodontitis by suppressing its stability

Immunity, Inflammation and Disease, 2023
AbstractIntroductionInflammasome and pyroptosis play important roles in periodontitis. Gasdermin D (GSDMD), a key factor in pyroptosis, is cleaved by caspase‐1 and regulated by ubiquitination. Synoviolin is a ubiquitin E3 ligase that interacts with GSDMD.
Ying Pang, Lili Liu, Shuainan Wu, Jianqi Wang, Lu Liu   +4 more
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Development of diagnostic and prognostic biomarker models for knee osteoarthritis based on NLRP3 inflammasome activation [PDF]

Journal of Medical Biochemistry
Background: This study aimed to characterize the expression profiles of the NOD-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome and its downstream effectors [Interleukin (IL)-1b, IL-18, and Gasdermin-D (GSDMD)] in degenerative knee ...
Xiong Shui, Zhou Junxin, Dong Yuying, Long Ling, Deng Gaorong   +4 more
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Gasdermin D Deficiency Does Not Protect Mice from High-Fat Diet-Induced Glucose Intolerance and Adipose Tissue Inflammation

Mediators of Inflammation, 2022
The adipose tissue NLRP3 inflammasome has recently emerged as a contributor to obesity-related metabolic inflammation. Recent studies have demonstrated that the activation of the NLRP3 inflammasome cleaves gasdermin D (GSDMD) and induces pyroptosis, a ...
Eun Bi Ma, Hafiz Muhammad Ahmad Javaid, Do-Hyeon Jung, Jong-Hwan Park, Joo Young Huh   +4 more
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