Results 11 to 20 of about 14,672 (225)

Crosstalk of HDAC4, PP1, and GSDMD in controlling pyroptosis

Cell Death and Disease
Gasdermin D (GSDMD) functions as a pivotal executor of pyroptosis, eliciting cytokine secretion following cleavage by inflammatory caspases. However, the role of posttranslational modifications (PTMs) in GSDMD-mediated pyroptosis remains largely ...
Weilv Xu, Qiao Jin, Xinyue Li, Danyue Li, Xinyu Fu, Nan Chen, Qian Lv, Yuhua Shi, Suhui He, Lu Dong, Yang Yang, Yuqi Yan, Fushan Shi   +12 more
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GSDMD-mediated pyroptosis promotes cardiac remodeling in pressure overload

Clinical and Experimental Hypertension, 2023
Background Gasdermin D (GSDMD) forms membrane pores to execute pyroptosis. But the mechanism of how cardiomyocyte pyroptosis induces cardiac remodeling in pressure overload remains unclear.
Jieyun You, Xuan Li, Fangjie Dai, Jun Liu, Qi Zhang, Wei Guo   +5 more
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Review: the role of GSDMD in sepsis

Inflammation Research, 2022
Gasdermin D (GSDMD) is a cytoplasmic protein that is encoded by the gasdermin family GSDMD gene and is the ultimate executor of pyroptosis. Pyroptosis is a mode of lysis and inflammation that regulates cell death, ultimately leading to cell swelling and rupture.
Shao, Ruifei, Lou, Xiran, Xue, Jinfang, Ning, Deyuan, Chen, Guobing, Jiang, Lihong   +5 more
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Mitochondrial GSDMD Pores DAMPen Pyroptosis [PDF]

Immunity, 2020
Noncanoncial inflammasome activation by cytosolic lipopolysaccharide (LPS) causes pyroptotic cell death facilitated by gasdermin D (GSDMD) pore formation. In this issue of Immunity, Huang et al. describe how cytosolic LPS in endothelial cells does not cause cell death but restrains endothelial cell proliferation.
Katherine C, Barnett, Jenny P-Y, Ting
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GSDMD-mediated pyroptosis: a critical mechanism of diabetic nephropathy [PDF]

Expert Reviews in Molecular Medicine, 2021
AbstractPyroptosis is a recently identified mechanism of programmed cell death related to Caspase-1 that triggers a series of inflammatory reactions by releasing several proinflammatory factors such as IL-1β and IL-18. The process is characterised by the rupture of cell membranes and the release of cell contents through the mediation of gasdermin (GSDM)
Yi Zuo, Li Chen, Huiping Gu, Xiaoyun He, Zhen Ye, Zhao Wang, Qixiang Shao, Caiping Xue   +7 more
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Structure insight of GSDMD reveals the basis of GSDMD autoinhibition in cell pyroptosis [PDF]

Proceedings of the National Academy of Sciences, 2017
Significance The protein gasdermin D (GSDMD) is the physiological substrate of inflammatory caspases and plays key roles in cell pyroptosis upon microbial infection and associated danger signals. GSDMD, as well as other gasdermin members, can bind lipid and form pore structures to induce pyroptosis.
Siyun, Kuang, Jun, Zheng, Hui, Yang, Suhua, Li, Shuyan, Duan, Yanfang, Shen, Chaoneng, Ji, Jianhua, Gan, Xue-Wei, Xu, Jixi, Li   +9 more
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Human polymorphisms in GSDMD alter the inflammatory response [PDF]

Journal of Biological Chemistry, 2020
Exomic studies have demonstrated that innate immune genes exhibit an even higher degree of variation than the majority of other gene families. However, the phenotypic implications of this genetic variation are not well understood, with effects ranging from hypomorphic to silent to hyperfunctioning.
Joseph K. Rathkey, Tsan S. Xiao, Derek W. Abbott   +2 more
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Snapshot of a Deadly Embrace: The Caspase-1-GSDMD Interface [PDF]

Immunity, 2020
Proteolytic maturation of the pore-forming protein gasdermin D (GSDMD) by inflammasome-activated caspase-1 is crucial for initiating pyroptosis, a lytic form of cell death. In this issue of Immunity, Lui et al. report the X-ray structure of the caspase-1-GSDMD complex, mapping the interaction interfaces that determine recognition and cleavage of GSDMD ...
Lieselotte, Vande Walle, Mohamed, Lamkanfi   +1 more
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Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis [PDF]

Cell, 2020
The pyroptosis execution protein GSDMD is cleaved by inflammasome-activated caspase-1 and LPS-activated caspase-11/4/5. The cleavage unmasks the pore-forming domain from GSDMD-C-terminal domain. How the caspases recognize GSDMD and its connection with caspase activation are unknown.
Kun, Wang, Qi, Sun, Xiu, Zhong, Mengxue, Zeng, Huan, Zeng, Xuyan, Shi, Zilin, Li, Yupeng, Wang, Qiang, Zhao, Feng, Shao, Jingjin, Ding   +10 more
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Pore formation by GSDMD is the effector mechanism of pyroptosis [PDF]

The EMBO Journal, 2016
Pyroptosis is a unique, pro‐inflammatory form of lytic cell death that is initiated by the activation of inflammatory caspases. The caspase substrate gasdermin D (GSDMD) plays a critical function in pyroptosis, yet the precise mode of action of this molecule in cell death execution remained unclear. Several recent reports, including a The EMBO Journal
Moritz M, Gaidt, Veit, Hornung
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