Results 11 to 20 of about 17,882 (284)

Crosstalk of HDAC4, PP1, and GSDMD in controlling pyroptosis

Cell Death and Disease
Gasdermin D (GSDMD) functions as a pivotal executor of pyroptosis, eliciting cytokine secretion following cleavage by inflammatory caspases. However, the role of posttranslational modifications (PTMs) in GSDMD-mediated pyroptosis remains largely ...
Weilv Xu, Qiao Jin, Xinyue Li, Danyue Li, Xinyu Fu, Nan Chen, Qian Lv, Yuhua Shi, Suhui He, Lu Dong, Yang Yang, Yuqi Yan, Fushan Shi   +12 more
doaj   +4 more sources

Structure insight of GSDMD reveals the basis of GSDMD autoinhibition in cell pyroptosis [PDF]

Proceedings of the National Academy of Sciences, 2017
Significance The protein gasdermin D (GSDMD) is the physiological substrate of inflammatory caspases and plays key roles in cell pyroptosis upon microbial infection and associated danger signals. GSDMD, as well as other gasdermin members, can bind lipid and form pore structures to induce pyroptosis.
Siyun, Kuang, Jun, Zheng, Hui, Yang, Suhua, Li, Shuyan, Duan, Yanfang, Shen, Chaoneng, Ji, Jianhua, Gan, Xue-Wei, Xu, Jixi, Li   +9 more
openaire   +3 more sources

Mitochondrial GSDMD Pores DAMPen Pyroptosis [PDF]

Immunity, 2020
Noncanoncial inflammasome activation by cytosolic lipopolysaccharide (LPS) causes pyroptotic cell death facilitated by gasdermin D (GSDMD) pore formation. In this issue of Immunity, Huang et al. describe how cytosolic LPS in endothelial cells does not cause cell death but restrains endothelial cell proliferation.
Katherine C, Barnett, Jenny P-Y, Ting
openaire   +4 more sources

Snapshot of a Deadly Embrace: The Caspase-1-GSDMD Interface [PDF]

Immunity, 2020
Proteolytic maturation of the pore-forming protein gasdermin D (GSDMD) by inflammasome-activated caspase-1 is crucial for initiating pyroptosis, a lytic form of cell death. In this issue of Immunity, Lui et al. report the X-ray structure of the caspase-1-GSDMD complex, mapping the interaction interfaces that determine recognition and cleavage of GSDMD ...
Lieselotte, Vande Walle, Mohamed, Lamkanfi   +1 more
openaire   +3 more sources

IRF2 transcriptionally induces GSDMD expression for pyroptosis

Science Signaling, 2019
Pyroptosis requires the induction of gasdermin D expression by the transcription factor IRF2.
Nobuhiko Kayagaki, Bettina L. Lee, Irma B. Stowe, Opher S. Kornfeld, Karen O'Rourke, Kathleen M. Mirrashidi, Benjamin Haley, Colin Watanabe, Merone Roose-Girma, Zora Modrusan, Sarah Kummerfeld, Rohit Reja, Yafei Zhang, Vicky Cho, T. Daniel Andrews, Lucy X. Morris, Christopher C. Goodnow, Edward M. Bertram, Vishva M. Dixit   +18 more
openaire   +3 more sources

TR4 worsen urosepsis by regulating GSDMD

European Journal of Medical Research
Abstract Background Urosepsis is a life-threatening organ disease in which pathogenic microorganisms in the urine enter the blood through the vessels, causing an imbalance in the immune response to infection. The aim of this study was to elucidate the role of testicular orphan receptor 4 (TR4) in urosepsis.
Huan Wang, Shibin Zhu, Zhenwei Zhou, Zhenghui Wang, Wei Zhuang, Dingwei Xue, Zeyi Lu, Qiming Zheng, Lifeng Ding, Liangliang Ren, Wenqing Luo, Ruyue Wang, Guangju Ge, Liqun Xia, Gonghui Li, Haiyang Wu   +15 more
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Review: the role of GSDMD in sepsis

Inflammation Research, 2022
Gasdermin D (GSDMD) is a cytoplasmic protein that is encoded by the gasdermin family GSDMD gene and is the ultimate executor of pyroptosis. Pyroptosis is a mode of lysis and inflammation that regulates cell death, ultimately leading to cell swelling and rupture.
Shao, Ruifei, Lou, Xiran, Xue, Jinfang, Ning, Deyuan, Chen, Guobing, Jiang, Lihong   +5 more
openaire   +2 more sources

A CD4+ T lymphocyte–specific TCR/GSDMD/IL-2 axis facilitates antitumor immunity

The Journal of Clinical Investigation
Gasdermin (GSDM) family proteins mediate tumor pyroptosis and impact cancer progression, but other than that, their involvement in the tumor immune microenvironment remains largely unknown.
Yihan Yao, Lingling Wang, Weiqin Jiang, Ning Wang, Mengjie Li, Wenlong Lin, Ting Zhang, Wanqiang Sheng, Xiaojian Wang   +8 more
doaj   +2 more sources

GSDMD-mediated pyroptosis: a critical mechanism of diabetic nephropathy [PDF]

Expert Reviews in Molecular Medicine, 2021
AbstractPyroptosis is a recently identified mechanism of programmed cell death related to Caspase-1 that triggers a series of inflammatory reactions by releasing several proinflammatory factors such as IL-1β and IL-18. The process is characterised by the rupture of cell membranes and the release of cell contents through the mediation of gasdermin (GSDM)
Yi Zuo, Li Chen, Huiping Gu, Xiaoyun He, Zhen Ye, Zhao Wang, Qixiang Shao, Caiping Xue   +7 more
openaire   +2 more sources

GSDMD pore structure reveals mechanism of preferential IL-1 release

, 2023
Paper accepted in principle in NatureInflammasomes are innate immune organelles that activate inflammatory caspases, which proteolytically process gasdermin D (GSDMD). In addition, caspase-1, one of the inflammatory caspases, cleaves inactive interleukin
Magupalli, Venkat G., Vora, Setu M., Wu, Hao, Wang, Longfei, Fu, Tian-Min, Pablo, Juan L., Dong, Ying, Greka, Anna, Zhang, Zhibin, Jacobson, Matthew P., Ruan, Jianbin, Lieberman, Judy, Xia, Shiyu   +12 more
core   +4 more sources