Results 41 to 50 of about 25,524 (331)
Pyroptosis- What We Know and the Road Ahead! [PDF]
Journal of Clinical and Diagnostic Research, 2022 Pyroptosis, a type of cell death, initiated by proinflammatory signals, is classically associated with inflammation. It was thought to occur mainly in macrophages and leukocytes during inflammatory conditions and involves the activation of caspase 1 ...
Anitha Krishnan Pandarathodiyil +3 more
doaj +1 more source
Immunity, 2023 Summary Gasdermin D (GSDMD)-activated inflammatory cell death (pyroptosis) causes mitochondrial damage, but its underlying mechanism and functional consequences are largely unknown. Here, we show that the N-terminal pore-forming GSDMD fragment (GSDMD-NT)
Rui Miao +26 more
semanticscholar +1 more source
Role of pyroptosis in the pathogenesis and treatment of diseases
MedComm, 2023 Programmed cell death (PCD) is regarded as a pathological form of cell death with an intracellular program mediated, which plays a pivotal role in maintaining homeostasis and embryonic development.
Xiangyu Jin +3 more
doaj +1 more source
Pyroptosis and Sarcopenia: Frontier Perspective of Disease Mechanism
Cells, 2022 With global ageing, sarcopenia, as an age-related disease, has brought a heavy burden to individuals and society. Increasing attention has been given to further exploring the morbidity mechanism and intervention measures for sarcopenia.
Hongfu Jin +5 more
doaj +1 more source
Frontiers in Immunology, 2022 BackgroundDuchenne muscular dystrophy (DMD) is the most common inherited human myopathy. Typically, the secondary process involving severe inflammation and necrosis exacerbate disease progression.
Nicolas Dubuisson +9 more
doaj +1 more source
Molecular mechanisms of gasdermin D pore-forming activity
Nature Immunology, 2023 The regulated disruption of the plasma membrane, which can promote cell death, cytokine secretion or both is central to organismal health. The protein gasdermin D (GSDMD) is a key player in this process.
Pascal Devant, Jonathan C. Kagan
semanticscholar +1 more source
Post-phagocytosis activation of NLRP3 inflammasome by two novel T6SS effectors
eLife, 2022 The type VI secretion system (T6SS) is used by bacteria to deliver toxic effectors directly into target cells. Most T6SSs mediate antibacterial activities, whereas the potential anti-eukaryotic role of T6SS remains understudied.
Hadar Cohen +5 more
doaj +1 more source
Gasdermin D-mediated pyroptosis: mechanisms, diseases, and inhibitors
Frontiers in Immunology, 2023 Gasdermin D (GSDMD)-mediated pyroptosis and downstream inflammation are important self-protection mechanisms against stimuli and infections. Hosts can defend against intracellular bacterial infections by inducing cell pyroptosis, which triggers the ...
Zhen Dai +5 more
semanticscholar +1 more source
Pyroptosis: Role and Mechanisms in Cardiovascular Disease
Frontiers in Cardiovascular Medicine, 2022 Cardiovascular disease (CVD) is a common disease that poses a huge threat to human health. Irreversible cardiac damage due to cardiomyocyte death and lack of regenerative capacity under stressful conditions, ultimately leading to impaired cardiac ...
Xinzhe Chen +4 more
doaj +1 more source
Gasdermins and their role in immunity and inflammation [PDF]
Journal of Experimental Medicine, 2019 The gasdermins are a family of pore-forming proteins recently implicated in the immune response. One of these proteins, gasdermin D (GSDMD), has been identified as the executioner of pyroptosis, an inflammatory form of lytic cell death that is induced upon formation of caspase-1–activating inflammasomes.
Pontus Orning +2 more
openaire +2 more sources