Results 41 to 50 of about 17,935 (273)
Gasdermin D: A potential mediator and prognostic marker of bladder cancer
Frontiers in Molecular Biosciences, 2022 Background: Bladder cancer is considered one of the commonest widespread cancers, its presentation ranges from non-muscle invasive form to being muscle-invasive. The gasdermin family of proteins consists of six proteins.
Randa El-Gamal +6 more
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Gasdermins against intracellular bacterial pathogens. [PDF]
Nat MicrobiolSouza FW, Liu Y, Trujillo J, Miao EA.
europepmc +3 more sources
Structure and assembly of a bacterial gasdermin pore [PDF]
Nature, 2023 Abstract In response to pathogen infection, gasdermin (GSDM) proteins form membrane pores that induce a host cell death process called pyroptosis 1–3 . Studies of human and mouse GSDM pores reveal the functions and architectures of 24–33 protomers assemblies 4–9
Alex G. Johnson +5 more
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‘Hints’ in the killer protein gasdermin D: unveiling the secrets of gasdermins driving cell death [PDF]
Cell Death & Differentiation, 2017 Pyroptosis is a lytic form of cell death distinguished from apoptosis, ferroptosis, necrosis, necroptosis, NETosis, oncosis, pyronecrosis and autophagy. Proinflammatory caspases cleave a gasdermin D (GSDMD) protein to generate a 31 kDa N-terminal domain.
Qiu, Shiqiao, Liu, Jing, Xing, Feiyue
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Frontiers in Immunology, 2023 Tuft cells are a type of rare epithelial cells that have been recently found to utilize taste signal transduction pathways to detect and respond to various noxious stimuli and pathogens, including allergens, bacteria, protists and parasitic helminths. It
Hao Lei +16 more
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Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012 Review on GSDMB (gasdermin B), with data on DNA, on the protein encoded, and where the gene is implicated.
Tamura, M, Shiroishi, T
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The role of pyroptosis and its crosstalk with immune therapy in breast cancer
Frontiers in Immunology, 2022 Pyroptosis is a brand-new category of programmed cell death (PCD) that is brought on by multitudinous inflammasomes, which can recognize several stimuli to pilot the cleavage of and activate inflammatory cytokines like IL-18 and IL-1β is believed to have
Ling Wu +7 more
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Intestinal Gasdermins for regulation of inflammation and tumorigenesis
Frontiers in Immunology, 2022 Gasdermins (GSDMs) protein family express in intestinal epithelial cells or lamina propria immune cells, and play a nonnegligible function during gut homeostasis. With the gradually in-depth investigation of GSDMs protein family, the proteases that cleave GSDMA-E have been identified.
Wenbin Gong +6 more
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Gasdermins: pore-forming activities and beyond [PDF]
Acta Biochimica et Biophysica Sinica, 2020 Gasdermins (GSDMs) belong to a protein superfamily that is found only in vertebrates and consists of GSDMA, GSDMB, GSDMC, GSDMD, DFNA5 (a.k.a. GSDME) and DFNB59 (a.k.a. Pejvakin (PJVK)) in humans. Except for DFNB59, all members of the GSDM superfamily contain a conserved two-domain structure (N-terminal and C-terminal domains) and share an ...
Zengzhang, Zheng +7 more
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Gasdermins deliver a deadly punch to cancer [PDF]
Cell Research, 2020 The pore-forming gasdermin proteins mediate a lytic and proinflammatory form of cell death called pyroptosis and have been linked to the host defense against infection. Two recent studies published in Nature revealed that induction of pyroptosis in tumor cells promotes anti-tumor activity, highlighting gasdermins as potential new targets in cancer ...
Cheng Shen, Abhimanu Pandey, Si Ming Man
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