Results 61 to 70 of about 25,524 (331)
Frontiers in Immunology, 2023 Tuft cells are a type of rare epithelial cells that have been recently found to utilize taste signal transduction pathways to detect and respond to various noxious stimuli and pathogens, including allergens, bacteria, protists and parasitic helminths. It
Hao Lei +16 more
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Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis
, 2020 Inflammasome-activated caspase-1 cleaves gasdermin D to unmask its pore-forming activity, the predominant consequence of which is pyroptosis. Here, we report an additional biological role for gasdermin D in limiting cytosolic DNA surveillance.
Sarkar, Saumendra N. +11 more
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The role of pyroptosis and its crosstalk with immune therapy in breast cancer
Frontiers in Immunology, 2022 Pyroptosis is a brand-new category of programmed cell death (PCD) that is brought on by multitudinous inflammasomes, which can recognize several stimuli to pilot the cleavage of and activate inflammatory cytokines like IL-18 and IL-1β is believed to have
Ling Wu +7 more
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Structure and assembly of a bacterial gasdermin pore
Nature, 2023 Abstract In response to pathogen infection, gasdermin (GSDM) proteins form membrane pores that induce a host cell death process called pyroptosis 1–3 . Studies of human and mouse GSDM pores reveal the functions and architectures of 24–33 protomers assemblies 4–9
Alex G. Johnson +5 more
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Modulation of Autoimmune and Autoinflammatory Diseases by Gasdermins
Frontiers in Immunology, 2022 Autoimmune diseases and autoinflammatory diseases are two types of the immune system disorders. Pyroptosis, a highly inflammatory cell death, plays an important role in diseases of immune system. The gasdermins belong to a pore-forming protein gene family which are mainly expressed in immune cells, gastrointestinal tract, and skin.
Fang Liang +3 more
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Gasdermin and Its Role in Pyroptosis
, 2022 The gasdermin family (GSDMs) contains a group of uncharacterized proteins that form membrane pores and serve as a major substrate for inflammatory caspases and the execution of pyroptosis, which is recognized as a novel type of programmed cell death [1].
Kasianenko, O. (Oksana) +1 more
core
Pyroptosis: A Newly Discovered Therapeutic Target for Ischemia-Reperfusion Injury
Biomolecules, 2022 Ischemia-reperfusion (I/R) injury, uncommon among patients suffering from myocardial infarction, stroke, or acute kidney injury, can result in cell death and organ dysfunction.
Yu Zheng +3 more
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Intestinal Gasdermins for regulation of inflammation and tumorigenesis
Frontiers in Immunology, 2022 Gasdermins (GSDMs) protein family express in intestinal epithelial cells or lamina propria immune cells, and play a nonnegligible function during gut homeostasis. With the gradually in-depth investigation of GSDMs protein family, the proteases that cleave GSDMA-E have been identified.
Wenbin Gong +6 more
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Caspase-5: Structure, Pro-Inflammatory Activity and Evolution
BiomoleculesCaspase-5 is a protease that induces inflammation in response to lipopolysaccharide (LPS), a component of the cell envelope of Gram-negative bacteria. The expression level of the CASP5 gene is very low in the basal state, but strongly increases in the ...
Leopold Eckhart, Heinz Fischer
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Not sorcery after all: Roles of multiple charged residues in membrane insertion of gasdermin-A3
Frontiers in Cell and Developmental Biology, 2022 Gasdermins execute programmatory cell death, known as pyroptosis, by forming medium-sized membrane pores. Recently, the molecular structure of those pores as well as the diversity in their shape and size have been revealed by cryoTEM and atomic force ...
Viktoria Korn, Kristyna Pluhackova
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