Results 71 to 80 of about 25,524 (331)

Evolutionary insights and functional diversity of gasdermin family proteins and homologs in microorganisms

Frontiers in Immunology
The gasdermin protein family and its homologs in microorganisms have gained significant attention due to their roles in programmed cell death, immune defense, and microbial infection.
Shule Wang, Shule Wang, Tingbo Ma, Tingbo Ma, Xiaoyi Xia, Leiliang Zhang, Leiliang Zhang   +6 more
doaj   +1 more source

The palmitoylation of gasdermin D directs its membrane translocation and pore formation during pyroptosis

Science immunology
Plasma membrane perforation elicited by caspase cleavage of the gasdermin D (GSDMD) N-terminal domain (GSDMD-NT) triggers pyroptosis. The mechanisms underlying GSDMD membrane translocation and pore formation are not fully understood.
A. Balasubramanian, A. Hsu, Laxman Ghimire, Muhammad Tahir, Pascal Devant, Pietro Fontana, Gang Du, Xing Liu, Fabin Dang, Hiroto Kambara, Xue-Mei Xie, Fei Liu, Tomoya Hasegawa, Rong Xu, H. Yu, Mei Chen, Steven Kolakowski, S. Trauger, M. R. Larsen, Wenyi Wei, Hao-Ying Wu, Jonathan C. Kagan, Judy Lieberman, Hong-Bo R. Luo   +23 more
semanticscholar   +1 more source

Targeting gasdermin E in neurodegenerative diseases

Cell Reports Medicine, 2023
Neel et al. identified pathophysiologic clues linking gasdermin-E (GSDME) with frontotemporal dementia and amyotrophic lateral sclerosis.1 Therapeutic studies targeting GSDME may provide a viable approach for neurodegenerative diseases.
Zhou, Zhi Dong, Yi, Ling Xiao, Tan, Eng King   +2 more
openaire   +2 more sources

Mechanisms of Gasdermin Family Members in Inflammasome Signaling and Cell Death [PDF]

, 2018
The Gasdermin (GSDM) family consists of Gasdermin A (GSDMA), Gasdermin B (GSDMB), Gasdermin C (GSDMC), Gasdermin D (GSDMD), Gasdermin E (GSDME) and Pejvakin (PJVK). GSDMD is activated by inflammasome-associated inflammatory caspases. Cleavage of GSDMD by
Daniel Fox, Si Ming Man, Fox, Daniel, Man, Si Ming, Shouya Feng, Feng, Shouya   +5 more
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

The Structural Basis for a Transition State That Regulates Pore Formation in a Bacterial Toxin

mBio, 2019
The cholesterol-dependent cytolysin (CDC) genes are present in bacterial species that span terrestrial, vertebrate, and invertebrate niches, which suggests that they have evolved to function under widely different environmental conditions.
Kristin R. Wade, Sara L. Lawrence, Allison J. Farrand, Eileen M. Hotze, Michael J. Kuiper, Michael A. Gorman, Michelle P. Christie, Santosh Panjikar, Craig J. Morton, Michael W. Parker, Rodney K. Tweten   +10 more
doaj   +1 more source

Microglial NLRP3-gasdermin D activation impairs blood-brain barrier integrity through interleukin-1β-independent neutrophil chemotaxis upon peripheral inflammation in mice

Nature Communications
Blood-brain barrier (BBB) disintegration is a key contributor to neuroinflammation; however, the biological processes governing BBB permeability under physiological conditions remain unclear.
Sung-Hyun Yoon, Chae Youn Kim, Eunju Lee, Changjun Lee, Kyung-Seo Lee, Jaeho Lee, H. Park, Bokeum Choi, Inhwa Hwang, Junhan Kim, Tae-Gyun Kim, Junghyun Son, Young-Min Hyun, Seunghee Hong, Je-Wook Yu   +14 more
semanticscholar   +1 more source

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

Targeting NSUN2‐Mediated m5C Modification Attenuates Chondrocyte Senescence and NLRP3 Activation in Osteoarthritis

Advanced Science, EarlyView.
NSUN2‐mediated m5C modification cooperates with ALYREF to stabilize and export IP3R3 mRNA, increasing IP3R3 expression and Ca2 + overload in chondrocytes. This signaling promotes mitochondrial dysfunction, NLRP3 inflammasome activation, and senescence, thereby accelerating osteoarthritis progression.
Guping Mao, Wei Li, Zhencan Lin, Zengfa Deng, Ming Li, Zongrui Jiang, Changzhao Li, Dianbo Long, Yan Kang   +8 more
wiley   +1 more source

Exploring the role of pyroptosis in the pathogenicity of heart disease

Frontiers in Physiology
Cell death is an essential cellular mechanism that ensures quality control and whole-body homeostasis. Various modes of cell death have been studied and detailed.
Rohail Bhatti, Priscila Y. Sato
doaj   +1 more source