Results 91 to 100 of about 25,524 (331)
MAPL regulates gasdermin-mediated release of mtDNA from lysosomes to drive pyroptotic cell death
Nature Cell BiologyMitochondrial control of cell death is of central importance to disease mechanisms from cancer to neurodegeneration. Mitochondrial anchored protein ligase (MAPL) is an outer mitochondrial membrane small ubiquitin-like modifier ligase that is a key ...
Mai Nguyen +10 more
semanticscholar +1 more source
, 2023 학위논문(석사)--아주대학교 일반대학원 :의생명과학과,2023. 2Gasdermin 계열 단백질은 세포막에 구멍을 만들어 파이롭토시스 (pyroptosis)를 일으키는 단백질로 최근에 밝혀졌다. 우리 연구실에서는 Gasdermin 계열 단백질들이 세포고사 엑소좀 (apoptotic exosome) 생합성에 관여하는 것을 규명하였다. Gasdermin 계열 단백질 중에서 세포고사 엑소좀 방출량이 가장 높은 Gasdermin E로 연구를 진행하였다.
강대욱
core
Advanced Science, EarlyView.The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt +16 more
wiley +1 more source
Rewiring Pyroptosis to Potentiate Cancer Immunotherapy via a Gasdermin D Agonist Bypassing Caspase‐3
Advanced Science, EarlyView.This work introduces a small‐molecule agonist, DIBDO, that bypasses Casp‐3 to directly trigger GSDMD‐mediated pyroptosis in tumors. Activated by glutathione, DIBDO generates singlet oxygen and molecular iodine, blocking Casp‐3 pathways and inducing immunogenic cell death.
Dan Zhao +6 more
wiley +1 more source
Regulation of Pyroptosis by ncRNA: A Novel Research Direction
Frontiers in Cell and Developmental Biology, 2022 Pyroptosis is a novel form of programmed cell death (PCD), which is characterized by DNA fragmentation, chromatin condensation, cell swelling and leakage of cell contents.
Liyuan Gao +4 more
doaj +1 more source
Advanced Science, EarlyView.A supramolecular pyroptotic thermal switch encapsulates I3− within β‐cyclodextrin (β‐CD) and undergoes CaCO3 mineralization. Upon lysosomal acidification, CaCO3 is degraded, releasing Ca2+ and I3−. Concurrently, BODIPY activation converts I3− into I2, inducing oxidative stress and Ca2+ overload, which together trigger caspase‐3/GSDME‐mediated ...
Dan Wu +8 more
wiley +1 more source
Pyroptosis and Its Role in Autoimmune Disease: A Potential Therapeutic Target
Frontiers in Immunology, 2022 Autoimmune diseases are a group of heterogeneous diseases with diverse clinical manifestations that can be divided into systemic and organ-specific. The common etiology of autoimmune diseases is the destruction of immune tolerance and the production of ...
Ruixuan You +11 more
doaj +1 more source
Atrial cardiomyocyte-restricted cleavage of gasdermin D promotes atrial arrhythmogenesis
European Heart JournalBackground and Aims Enhanced inflammatory signalling causally contributes to atrial fibrillation (AF) development. Gasdermin D (GSDMD) is an important downstream effector of several inflammasome pathways.
Yue Yuan +13 more
semanticscholar +1 more source
Synchronized Imaging of Hydrogen Peroxide and Hydroxyl Radical in Pyroptosis and Epilepsy
Advanced Science, EarlyView.A dual‐responsive fluorescent probe, HH, enables synchronized visualization of H2O2 and •OH through spectrally resolved green and red channels. By tracking redox dynamics in pyroptosis and epilepsy models, HH reveals ROS elevation during seizure‐like pathology and supports evaluation of antioxidant and antiepileptic therapeutic interventions.
Yabing Gan +9 more
wiley +1 more source
Recent insights on inflammasomes, gasdermin pores, and pyroptosis
, 2020 Inflammasomes assemble in the cytosol of myeloid and epithelial cells on sensing of cellular stress and pathogen-associated molecular patterns and serve as scaffolds for recruitment and activation of inflammatory caspases.
Moraes de Vasconcelos, Nathalia +1 more
core +1 more source