Results 101 to 110 of about 21,860 (253)

MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition [PDF]

, 2019
The nucleotide-binding-domain (NBD)-and leucine-rich repeat (LRR)-containing (NLR) family, pyrin-domain-containing 3 (NLRP3) inflammasome drives pathological inflammation in a suite of autoimmune, metabolic, malignant, and neurodegenerative diseases ...
Demon, Dieter, Fossoul, Amelie, Kayagaki, Nobuhiko, Konvalinka, Jan, Kostka, Libor, Lamkanfi, Mohamed, Lee, Bettina L, Pham, Victoria C, Sacha, Pavel, Simon, Petr, Staben, Steven T, Stivala, Craig E, Stowe, Irma B, Subrt, Vladimir, Van Hauwermeiren, Filip, Vande Walle, Lieselotte, Viana Saavedra, Pedro Henrique, Yamazoe, Sayumi   +17 more
core   +1 more source

Novel Organelle‐Based Intracellular Immunity With Mechanistic and Therapeutic Implications

Barrier Immunity, EarlyView.
A conceptual framework illustrating how PAMPs/DAMPs initiate barrier, innate, adaptive, and intracellular immune responses, with organelle‐based intracellular immunity serving as a central integrator linking metabolism, inflammatory signaling, and therapeutic interventions to restore immune homeostasis.
Keman Xu, Shih‐Yu Hung, Fatma Saaoud, Ying Shao, Yifan Lu, Juanjuan Liu, Bo Yuan, Haiyan Xiang, Hong Wang, Xiaofeng Yang   +9 more
wiley   +1 more source

Monitoring gasdermin pore formation in vitro

, 2019
The gasdermin (GSDM) family consists of gasdermin A (GSDMA), B (GSDMB), C (GSDMC), D (GSDMD), E or DNFA5 (GSDME), and DFNB59 in human. Expressed in the skin, gastrointestinal tract, and various immune cells, GSDMs mediate homeostasis and inflammation upon activation by caspases and unknown proteases.
Shiyu, Xia, Jianbin, Ruan, Hao, Wu
openaire   +3 more sources

Functional Materials Targeted Regulation of Gasdermins: From Fundamentals to Functionalities and Applications

Advanced Science
Targeted regulation of pyroptosis to modulate the immune landscape has emerged as a novel design strategy for cancer immunotherapy and anti‐inflammatory therapy. However, pyroptosis acts as a double‐edged sword, making it important to optimize the design
Luyao Tian, Shuo Piao, Xia Li, Lanping Guo, Luqi Huang, Wenyuan Gao   +5 more
doaj   +1 more source

Gasdermin D is required for pyroptosis and secretion of interleukin-1β [PDF]

, 2016
炎性小体是细胞内由caspase-1，ASC，NALP等组成的蛋白复合体，也是先天免疫系统的一个重要组成。炎性小体被激活后会促进白介素1β（IL-1β）和IL-18的剪切与分泌，并触发细胞焦亡的发生。细胞焦亡是近年来发现并证实的一种新的程序性细胞死亡方式，其特征为依赖于caspase-1，并伴随有促炎症因子的释放。尽管其在先天免疫和内毒素休克方面扮演着重要角色，但细胞焦亡被诱导发生的机制仍不清楚。本文通过基于CRISPR-Cas9的基因敲除方法鉴定到了gasderminD（GSDMD ...
万浩强
core  

Pharmacological effects of gastrodin: Insight into neurological diseases and mechanism in ferroptosis and pyroptosis

Ibrain, Volume 11, Issue 1, Page 74-83, Spring 2025.
Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley   +1 more source

Pyroptosis‐Inducing Biomaterials Pave the Way for Transformative Antitumor Immunotherapy

Advanced Science
Pyroptosis can effectively overcome immunosuppression and reactivate antitumor immunity. However, pyroptosis initiation is challenging. First, the underlying biological mechanisms of pyroptosis are complex, and a variety of gasdermin family proteins can ...
Hao Yin, Tanzhou Chen, Xiaoqu Hu, Wenting Zhu, Yida Li, Wenjie Sun, Lei Li, Hongmei Zhang, Qinyang Wang   +8 more
doaj   +1 more source

RIPK3 restricts viral pathogenesis via cell death-independent neuroinflammation [PDF]

, 2017
Receptor-interacting protein kinase-3 (RIPK3) is an activator of necroptotic cell death, but recent work has implicated additional roles for RIPK3 in inflammatory signaling independent of cell death.
Daniels, Brian P., Gale, Michael, Loo, Yueh-Ming, Martinez, Jennifer, Oberst, Andrew, Oguin III, Thomas H., Olsen, Tayla M., Orozco, Susana, Snyder, Annelise G., Tait, Stephen W.G.   +9 more
core   +1 more source

Berberine alleviates cell pyroptosis in diabetic retinopathy by regulating AKT1, JUN, and STAT3

Ibrain, EarlyView.
Berberine alleviates diabetic retinopathy by reducing pyroptosis through AKT1/JUN/STAT3 regulation, as validated in rat models via network pharmacology, molecular docking, and experimental assays. Abstract Berberine (BBR) exerts an effective protection for diabetic retinopathy (DR), but the underlying key molecular mechanism remains unknown; this study
Na Li, Ji‐Lin Chen, Yi‐Jian Sun, Jia‐Fan Sun, Fatin Athirah Pauzi, Song‐Lin Zhu, Amy Yi Hsan Saik, Alan Han‐Kiat Ong   +7 more
wiley   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source