Results 101 to 110 of about 17,935 (273)

A New Paradigm: 46 Structural Cell Types Function as Environment‐Supporting Innate Immune Cells, With Endothelial and Vascular Smooth Muscle Cells as Key Prototypes

iNew Medicine, EarlyView.
ABSTRACT The scope, organization, and biological significance of innate immune functions across structural cell types remain poorly defined. To address these fundamental knowledge gaps, we analyzed experimental data of transcriptomes generated by our group and others.
Juanjuan Liu, Gayani K. Nanayakkara, Yifan Lu, Fatma Saaoud, Keman Xu, Ying Shao, Bo Yuan, Shih‐Yu Hung, Haiyan Xiang, Xianwei Wang, Sadia Mohsin, Sheng Wu, Xiaolei Liu, Juncheng Wei, Zhengjie Zhou, Beata Kosmider, Mingui Fu, Laisel Martinez, Roberto Vazquez‐Padron, Wenhui Hu, Shuping Ge, Hong Wang, Xiaofeng Yang   +22 more
wiley   +1 more source

Targeting eIF5A combats breast cancer progression by ClpP‐dependent mitochondrial oxidative stress

Interdisciplinary Medicine, EarlyView.
This study identified the eIF5A‐ClpP axis as a key driver of breast cancer progression. Targeting eIF5A suppresses tumor growth by inducing ClpP‐dependent mitochondrial oxidative stress, revealing a novel therapeutic vulnerability. Abstract Breast cancer (BC) poses a persistent global health challenge, necessitating new therapeutic targets.
Jinmei Zhu, Baoyuan Tang, Bei Xie, Haohua Deng, Haitang Yang, Lei Ma, Ziqing Zhang, Yicheng Ma, Xingyuan Ma, Shuaiyang Wang, Jing Li, Lei Zhao, Wengui Shi, Linjing Li   +13 more
wiley   +1 more source

Gasdermins and pannexin-1 mediate pathways of chemotherapy-induced cell lysis in hematopoietic malignancies

, 2022
Bowen Zhou, Christopher B. Ryder, George Dubyak, Derek W. Abbott   +3 more
openalex   +2 more sources

DL-3-n-Butylphthalide Attenuates Myocardial Hypertrophy by Targeting Gasdermin D and Inhibiting Gasdermin D Mediated Inflammation [PDF]

, 2021
Bingjiang Han, Jiajun Xu, Xiaowen Shi, Zhanxiong Zheng, Fengjie Shi, Fenfen Jiang, Jibo Han   +6 more
openalex   +1 more source

Intelligent design of artificial biocatalyst for biomedical diseases

Journal of Intelligent Medicine, EarlyView.
This review summarizes recent advances in the intelligent design of artificial biocatalysts for biomedical diseases. By leveraging tailored design strategies, including environment‐responsive engineering and rational/artificial intelligence‐aided optimization, these biocatalysts enable precise modulation of pathological microenvironments and targeted ...
Lijie Zhang, Nan Song, Huanhuan Qiao, Si Sun   +3 more
wiley   +1 more source

The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity

Cell Reports, 2017
Inflammasomes activate the protease caspase-1, which cleaves interleukin-1β and interleukin-18 to generate the mature cytokines and controls their secretion and a form of inflammatory cell death called pyroptosis.
Katharina S. Schneider, Christina J. Groß, Roland F. Dreier, Benedikt S. Saller, Ritu Mishra, Oliver Gorka, Rosalie Heilig, Etienne Meunier, Mathias S. Dick, Tamara Ćiković, Jan Sodenkamp, Guillaume Médard, Ronald Naumann, Jürgen Ruland, Bernhard Kuster, Petr Broz, Olaf Groß   +16 more
doaj   +1 more source

Biological activities and bioactive constituents of Flammulina velutipes: An updated systematic review

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Flammulina velutipes (enokitake) is an edible mushroom recognized for both its nutritional and medicinal properties. It exhibits a broad spectrum of biological activities, including antioxidant, anti‐inflammatory, antitumor, immunomodulatory, and gut microbiota‐regulating effects.
Rıdvan Özgen, Didem Şöhretoğlu, Ayşe Kuruüzüm‐Uz   +2 more
wiley   +1 more source

Proteomics‐Based Identification of the Pyroptosis‐Related Biomarker PCSK9 and Its Association With the Pathogenesis of Rheumatoid Arthritis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Rheumatoid arthritis (RA) is a common autoimmune disease, and early diagnosis is critical for effective treatment. This study aims to identify potential biomarkers related to pyroptosis through serum proteomics analysis, offering new insights for the early diagnosis of RA.
Lei Wang, Hao‐Jie Chen, Ting‐Ting Wu, Xin‐Yi Shen, Ying‐Ying Gao, Yu‐Feng Yin, Tian Ren, Xin Chu, Jing Cao, Tao Cheng, Ming‐Jun Wang   +10 more
wiley   +1 more source

RBMX Transcriptionally Repressed by EZH2‐Associated H3K27me3 Modification Attenuates Pyroptosis in Renal Ischemia/Reperfusion Injury via Regulating SIRT3/NLRP3 Inflammasome Activation

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Ischemic reperfusion injury (IRI) to kidney is a significant clinical factor in acute kidney injury (AKI). This study aimed to investigate the new role of RNA‐binding motif protein X‐linked (RBMX), a modulator of m6A methylation, in renal IRI and to examine the associated regulatory mechanisms. An in vitro renal IRI model was established using
Yi‐Han Wang, Yan Teng, Fang‐Lan Yao, Shu‐Qi Wei, Yan Li   +4 more
wiley   +1 more source

Peptide binding at the gasdermin D exosite reveals the structural basis for targeting the site. [PDF]

Acta Crystallogr D Struct Biol
We describe the first structure of gasdermin D with a putative caspase inhibitor peptide analog at 1.6 Å resolution. This work suggests potential druggability of gasdermin D at the exosite by leveraging structure‐based computational design with biochemical characterization.Gasdermin D (GSDMD) has been identified as a critical component of the ...
Wang R, Ho T, Ogawa A, Widjaja K, Brown Z, Yang S, Huo P, Gregory MC, Singh A, Perumal S, Lin S, Cheng AC, Garrenton LS, Mu J, Ogawa A, Chrencik JE.   +15 more
europepmc   +2 more sources