Results 1 to 10 of about 4,132 (107)

Epithelial-Mesenchymal Transition Induces GSDME Transcriptional Activation for Inflammatory Pyroptosis

Frontiers in Cell and Developmental Biology, 2021
GSDME is a newly recognized executor of cellular pyroptosis, and has been recently implicated in tumor growth and immunity. However, knowledge about the molecular regulators underlying GSDME abundance remains limited.
Guanglei Zhuang, Zhuang Yu, Mei-Chun Cai   +2 more
exaly   +3 more sources

GSDME in Endothelial Cells: Inducing Vascular Inflammation and Atherosclerosis via Mitochondrial Damage and STING Pathway Activation

Biomedicines, 2023
The initiation of atherosclerotic plaque is characterized by endothelial cell inflammation. In light of gasdermin E’s (GSDME) role in pyroptosis and inflammation, this study elucidates its function in atherosclerosis onset.
, , Shiyao Xie
exaly   +3 more sources

The Very Virulent IBDV Viral Protein VP3 Promotes the Caspase-3 Mediated Cleavage of GSDME [PDF]

Veterinary Sciences
The infectious bursal disease virus (IBDV) can cause severe immunosuppression and high mortality in chickens, posing a significant threat to the poultry farming industry.
Tao Zhang, Suyan Wang, Xiaole Qi, Lijie Tang, Yulong Gao   +4 more
doaj   +2 more sources

Gasdermin E (GSDME)—A New Potential Marker of Psoriasis and Its Metabolic Complications: The First Combined Study on Human Serum, Urine and Tissue

Cells, 2023
Psoriasis is a frequent and incurable skin disease whose pathogenesis is still not fully understood. It is characterized by immune disturbances leading to hyperproliferation and improper differentiation of keratinocytes.
Anna Pryczynicz, Dariusz Pawlak, Justyna Hermanowicz   +2 more
exaly   +3 more sources

ZNF460 Promotes GSDME-Driven Pyroptosis via PKM2 Transcriptional Activation in Aortic Dissection [PDF]

Reviews in Cardiovascular Medicine
Background: Aortic dissection (AD) is a cardiovascular emergency with high mortality; however, the underlying molecular pathophysiology of AD remains incompletely understood. Pyroptosis, a proinflammatory form of programmed cell death,
Quanlin Yang, Xin Shao, Zihe Zheng, Mingliang Li, Changbo Xiao, Bo Chen, Guowei Tu, Ben Huang, Xiaofu Dai   +8 more
doaj   +2 more sources

Antitumor Effect of Simvastatin in Combination With DNA Methyltransferase Inhibitor on Gastric Cancer via GSDME-Mediated Pyroptosis

Frontiers in Pharmacology, 2022
Gasdermin E (GSDME) is one of the executors of pyroptosis, a type of programmed lytic cell death, which can be triggered by caspase-3 activation upon stimulation.
Wei-Lin Jin, Daxiang Cui
exaly   +3 more sources

Structural basis and regulation of GSDME pore formation [PDF]

Nature Communications
Gasdermins (GSDMs) are pore-forming proteins that mediate pyroptosis and contribute to inflammatory and cancer-related processes. Although GSDME shares structural similarity with other gasdermins, its activation and pore assembly mechanisms remain ...
Evelyn Teran, Tian Tian, Chengliang Wang, Xinzheng Wang, Jinghan Wang, Dongchun Ni, Vijay A. Rathinam, Jianbin Ruan   +7 more
doaj   +2 more sources

Curcumin enhances GSDME-mediated pyroptosis to potentiate PD-1/PD-L1 immune checkpoint blockade in colorectal cancer [PDF]

Frontiers in Pharmacology
Colorectal cancer (CRC) patients with a microsatellite-stable (MSS) status exhibit poor responsiveness to PD-1/PD-L1 blockade. Pyroptosis induction may resensitize MSS tumors to PD-1/PD-L1 blockade; however, the expression of GSDME, a key executor of ...
Dongsheng Tan, Gengdong Li, Xiaoda Li, Weiwei Zhai, Weiwei Zhai, Lijia Jing, Lijia Jing   +6 more
doaj   +2 more sources

Compound loss of GSDMD and GSDME function is necessary to achieve maximal therapeutic effect in colitis

Journal of Translational Autoimmunity, 2022
Gasdermin D (GSDMD) and gasdermin E (GSDME) perpetuate inflammation by mediating the release of cytokines such as interleukin-1β (IL-1β) and IL-18. However, not only are the actions of GSDMD in colitis still controversial, but its interplay with GSDME in
Yousef Abu-Amer, Jianqiu Xiao, Gabriel Mbalaviele   +2 more
exaly   +3 more sources

GSDME in cardiovascular diseases: research system and contemporary progress [PDF]

Frontiers in Immunology
Despite considerable advancements in treatment technologies in recent years, cardiovascular diseases still pose a significant threat to human health.
Zhenzhen Yang, Zilong Luo, Han Zhang, Han Zhang, Junjie Zong, Junjie Zong, Pinyan Huang, Pinyan Huang, Yuqing Niu, Cheng Zhou, Cheng Zhou, Song Wang, Song Wang, Dan Zhang, Dan Zhang   +14 more
doaj   +2 more sources