Results 1 to 10 of about 5,373 (177)

GSDME in Endothelial Cells: Inducing Vascular Inflammation and Atherosclerosis via Mitochondrial Damage and STING Pathway Activation

Biomedicines, 2023
The initiation of atherosclerotic plaque is characterized by endothelial cell inflammation. In light of gasdermin E’s (GSDME) role in pyroptosis and inflammation, this study elucidates its function in atherosclerosis onset.
Shiyao Xie, Enyong Su
exaly   +4 more sources

Gasdermin E (GSDME)—A New Potential Marker of Psoriasis and Its Metabolic Complications: The First Combined Study on Human Serum, Urine and Tissue

Cells, 2023
Psoriasis is a frequent and incurable skin disease whose pathogenesis is still not fully understood. It is characterized by immune disturbances leading to hyperproliferation and improper differentiation of keratinocytes.
Beata Sieklucka, Anna Pryczynicz, Dariusz Pawlak   +2 more
exaly   +4 more sources

Compound loss of GSDMD and GSDME function is necessary to achieve maximal therapeutic effect in colitis [PDF]

Journal of Translational Autoimmunity, 2022
Gasdermin D (GSDMD) and gasdermin E (GSDME) perpetuate inflammation by mediating the release of cytokines such as interleukin-1β (IL-1β) and IL-18. However, not only are the actions of GSDMD in colitis still controversial, but its interplay with GSDME in
Yousef Abu-Amer, Jianqiu Xiao, Gabriel Mbalaviele   +2 more
exaly   +4 more sources

Epithelial-Mesenchymal Transition Induces GSDME Transcriptional Activation for Inflammatory Pyroptosis

Frontiers in Cell and Developmental Biology, 2021
GSDME is a newly recognized executor of cellular pyroptosis, and has been recently implicated in tumor growth and immunity. However, knowledge about the molecular regulators underlying GSDME abundance remains limited.
Guanglei Zhuang, Jingyu Zang, Zhuang Yu
exaly   +3 more sources

Antitumor Effect of Simvastatin in Combination With DNA Methyltransferase Inhibitor on Gastric Cancer via GSDME-Mediated Pyroptosis

Frontiers in Pharmacology, 2022
Gasdermin E (GSDME) is one of the executors of pyroptosis, a type of programmed lytic cell death, which can be triggered by caspase-3 activation upon stimulation.
Wei-Lin Jin, Daxiang Cui
exaly   +3 more sources

TNFSF15 inhibits progression of diabetic retinopathy by blocking pyroptosis via interacting with GSDME

Cell Death and Disease
Diabetic retinopathy is a common microvascular complication of diabetes and a leading cause of blindness. Pyroptosis has emerged as a mechanism of cell death involved in diabetic retinopathy pathology.
Hongkun Zhao, Yating Dai, Yunqin Li, Juanjuan Li, Hua Li   +4 more
doaj   +2 more sources

Metformin Inhibited GSDME to Suppress M2 Macrophage Pyroptosis and Maintain M2 Phenotype to Mitigate Cisplatin-Induced Intestinal Inflammation

Biomedicines
Background: The continuous clinical use of cisplatin is prevented by gastrointestinal toxicity. Methods: Cisplatin was used to treat THP-1-derived macrophages to see its differential effects on different subtypes of macrophages.
Ke Jiang, Qi He, Chenhui Wang, Wen Yang, Changdong Zhou, Jian Li, Jiangbo Li, Yuke Cui, Jingqi Shi, Zhenqiao Wei, Yuanyuan Jiao, Ligai Bai, Shengqi Wang, Liang Guo   +13 more
doaj   +2 more sources

The Role and Mechanism of GSDME-Dependent Pyroptosis in Cochlear Marginal Cells Injury by Cisplatin

Biomedicines
Background: Elucidating the mechanisms underlying cisplatin-induced ototoxicity is critical for the clinical management of hearing loss. While cisplatin is known to penetrate the inner ear via the blood-labyrinth barrier in the stria vascularis, its ...
Wenyang Lei, Wenting Yu, Ting Li, Wei Tang, Shimin Zong, Hongjun Xiao   +5 more
doaj   +2 more sources

Oncolytic virus-delivered GSDME: Unlocking pyroptosis to improve dendritic cell function and amplify cytotoxic T cell response. [PDF]

Mol Ther Oncol
Oncolytic virotherapy is a promising strategy for advanced cancers, but clinical success remains limited. Combining oncolytic viruses with immunogenic cell death modalities offers a potential solution.
Schneider S, Schwaiger T, Kröll J, Basbas I, Martin F, Xin D, Podgorschek E, Arnkil I, Glatz M, Mayr M, Petersson M, Scheidl S, Schneeberger S, Das K, Spiesschaert B, Mandl C, Carotta S, Knobbe-Thomsen CB, Elbers K, Nolden T.   +19 more
europepmc   +2 more sources

GSDME-N-induced mitochondrial neurotoxicity in early neurodegeneration was suppressed by nicotine via enhancing autophagic flux

Journal of Translational Medicine
Background Neurodegeneration is a chronic, progressive process initiated by early neurite retraction, a pathological hallmark preceding neuronal death in neurodegenerative disorders such as Parkinson’s disease (PD).
Junjun Zhao, Saitao Qiu, Angyang Guo, Haixia Huang, Wei Wang, Jianliang Zhang   +5 more
doaj   +2 more sources