Results 11 to 20 of about 5,373 (177)

Lenvatinib promotes hepatocellular carcinoma pyroptosis by regulating GSDME palmitoylation

Cancer Biology and Therapy
Lenvatinib, as a multi-kinase inhibitor, has been approved as a first-line drug for patients with advanced hepatocellular carcinoma (HCC). Gasdermin E (GSDME)-mediated pyroptosis, a form of programmed cell death, can be induced by chemotherapy drugs or ...
Pei-yuan Li, Xing-Xing He, Mu-Ru Wang
exaly   +3 more sources

GSDME knockout alleviates hematopoietic stem cell irradiation injury and aggravates myeloid-biased differentiation [PDF]

Frontiers in Cell and Developmental Biology
BackgroundBone marrow (BM) suppression is the most prevalent dose-limiting side effect of chemotherapy and radiotherapy. Exposure to ionizing radiation (IR) results in acute BM suppression and long-term BM injury.
Lulu Su, Lulu Su, Yinping Dong, Bowen Guan, Yuquan Wang, Yanhua Lu, Xinyue Wang, Wenxuan Li, Qidong Huo, Aimin Meng, Deguan Li   +10 more
doaj   +2 more sources

IFI27 and BAX are Essential for GSDME-Mediated Myeloma Cell Pyroptosis. [PDF]

Adv Sci (Weinh)
The proposed model of GSDME‐mediated MM cell pyroptosis modulated by IFI27 and BAX. IFI27 is downregulated in MM cells. Upon pyroptotic stimulation, such as DOX or ETO treatment, IFI27 is induced, therefore liberating BAX from BCL‐2 ❶. BAX is then recruited to mitochondria and forms homo‐oligomeric channels in OMM, therefore leading to cytochrome C ...
Cui Y, Sun Y, Liu Z, Lai X, Zhao Y, Wang Y, He Y, Xu F, Feng D, Liu L, Huang Z, Xing L, Mao X.   +12 more
europepmc   +2 more sources

Gasdermin-E Mediated Pyroptosis—A Novel Mechanism Regulating Migration, Invasion and Release of Inflammatory Cytokines in Rheumatoid Arthritis Fibroblast-like Synoviocytes

Frontiers in Cell and Developmental Biology, 2022
Synovium fibroblast-like synoviocytes (FLSs) are important participants in the pathogenesis of synovitis and joint destruction in rheumatoid arthritis (RA).
Tao Wu, Xue-Pei Zhang, Qian Zhang, Yao-Yao Zou, Jian-Da Ma, Le-Feng Chen, Yao-Wei Zou, Ji-Meng Xue, Ruo-Fan Ma, Zhong Chen, Lie Dai   +10 more
doaj   +1 more source

Gasdermin E deficiency attenuates acute kidney injury by inhibiting pyroptosis and inflammation

Cell Death and Disease, 2021
Pyroptosis, one kind of inflammatory regulated cell death, is involved in various inflammatory diseases, including acute kidney injury (AKI). Besides Gasdermin D (GSDMD), GSDME is a newly identified mediator of pyroptosis via the cleavage of caspase-3 ...
Weiwei Xia, Yuanyuan Li, Mengying Wu, Qianqian Jin, Qian Wang, Shuzhen Li, Songming Huang, Aihua Zhang, Yue Zhang, Zhanjun Jia   +9 more
doaj   +1 more source

GSDME maintains hematopoietic stem cells by balancing pyroptosis and apoptosis

Blood Science, 2021
. GSDME contains a pore-forming domain at its N-terminal region to execute pyroptosis. Our previous study has reported that forced expression of Gsdme impairs the reconstitution capacity of hematopoietic stem cells (HSCs).
Xiuxiu Yang, Tingting Cong, Hanqing He, Jianwei Wang   +3 more
doaj   +1 more source

GSDME deficiency leads to the aggravation of UVB-induced skin inflammation through enhancing recruitment and activation of neutrophils

Cell Death and Disease, 2022
Gasdermin E (GSDME)-mediated pyroptosis is induced in keratinocytes of UVB-challenged skin. The role of GSDME in UVB-caused skin damage remains unknown. To explore the role of GSDME in UVB-induced skin inflammation.
Yujie Chen, Ni Lian, Sihan Chen, Ta Xiao, Yangying Ke, Yiqun Zhang, Changjun Song, Yong Yang, Song Xu, Heng Gu, Xu Chen   +10 more
doaj   +1 more source

Gasdermin E regulates the stability and activation of EGFR in human non-small cell lung cancer cells

Cell Communication and Signaling, 2023
Background Lung cancer is the most lethal malignancy, with non-small cell lung cancer (NSCLC) being the most common type (~ 85%). Abnormal activation of epidermal growth factor receptor (EGFR) promotes the development of NSCLC.
Limei Xu, Feifei Shi, Yingdi Wu, Shun Yao, Yingying Wang, Xukai Jiang, Ling Su, Xiangguo Liu   +7 more
doaj   +1 more source

Gasdermin-E-mediated pyroptosis participates in the pathogenesis of Crohn’s disease by promoting intestinal inflammation

Cell Reports, 2021
Summary: Crohn’s disease (CD) is a kind of refractory intestinal inflammatory diseases. Pyroptosis was recently identified as a gasdermin-mediated proinflammatory cell death.
Gao Tan, Chongyang Huang, Jiaye Chen, Bingxia Chen, Fachao Zhi   +4 more
doaj   +1 more source

Investigating the Prognostic Significance of Pyroptosis-Related Genes in Gastric Cancer and Their Impact on Cells’ Biological Functions

Frontiers in Oncology, 2022
ObjectiveTo probe into the role of pyroptosis-related genes in gastric cancer.MethodsTo establish pyroptosis-related genes, observe their expression in gastric cancer, and analyze the prognosis of pyroptosis-related genes in gastric cancer by single ...
Jie Yin, Gang Che, Wankun Wang, Shitu Chen, Jian Liu   +4 more
doaj   +1 more source