Results 11 to 20 of about 5,022 (197)

IFI27 and BAX are Essential for GSDME-Mediated Myeloma Cell Pyroptosis. [PDF]

Adv Sci (Weinh)
The proposed model of GSDME‐mediated MM cell pyroptosis modulated by IFI27 and BAX. IFI27 is downregulated in MM cells. Upon pyroptotic stimulation, such as DOX or ETO treatment, IFI27 is induced, therefore liberating BAX from BCL‐2 ❶. BAX is then recruited to mitochondria and forms homo‐oligomeric channels in OMM, therefore leading to cytochrome C ...
Cui Y, Sun Y, Liu Z, Lai X, Zhao Y, Wang Y, He Y, Xu F, Feng D, Liu L, Huang Z, Xing L, Mao X.   +12 more
europepmc   +3 more sources

Gasdermin E (GSDME)—A New Potential Marker of Psoriasis and Its Metabolic Complications: The First Combined Study on Human Serum, Urine and Tissue

Cells, 2023
Psoriasis is a frequent and incurable skin disease whose pathogenesis is still not fully understood. It is characterized by immune disturbances leading to hyperproliferation and improper differentiation of keratinocytes.
Anna Pryczynicz, Dariusz Pawlak, Justyna Hermanowicz   +2 more
exaly   +4 more sources

Structural basis and regulation of GSDME pore formation [PDF]

Nature Communications
Gasdermins (GSDMs) are pore-forming proteins that mediate pyroptosis and contribute to inflammatory and cancer-related processes. Although GSDME shares structural similarity with other gasdermins, its activation and pore assembly mechanisms remain ...
Evelyn Teran, Tian Tian, Chengliang Wang, Xinzheng Wang, Jinghan Wang, Dongchun Ni, Vijay A. Rathinam, Jianbin Ruan   +7 more
doaj   +4 more sources

Lenvatinib promotes hepatocellular carcinoma pyroptosis by regulating GSDME palmitoylation

Cancer Biology and Therapy
Lenvatinib, as a multi-kinase inhibitor, has been approved as a first-line drug for patients with advanced hepatocellular carcinoma (HCC). Gasdermin E (GSDME)-mediated pyroptosis, a form of programmed cell death, can be induced by chemotherapy drugs or ...
Pei-Yuan Li, Xing-Xing He
exaly   +5 more sources

Plasma membrane perforation by GSDME during apoptosis-driven secondary necrosis [PDF]

Cellular and Molecular Life Sciences, 2022
Secondary necrosis has long been perceived as an uncontrolled process resulting in total lysis of the apoptotic cell. Recently, it was shown that progression of apoptosis to secondary necrosis is regulated by Gasdermin E (GSDME), which requires ...
Ramon, JanaUGent0001309371658020029681359767496646690000-0002-0247-41764EC2A004-1D89-11E3-818F-FB6410BDE39D, Braeckmans, KevinFW018010013405760000-0002-7993-6295F5BF560A-F0ED-11E1-A9DE-61C894A0A6B4, De Tender, CarolineWE100000800631908020019087140000-0003-4804-13810FBB232C-F0EE-11E1-A9DE-61C894A0A6B4, Vandenabeele, PeterCA05WE140019790145118010005653840000-0002-6669-8822F4243658-F0ED-11E1-A9DE-61C894A0A6B4, De Schutter, Elke0001614943878020026271209784632147350000-0003-1500-953780A1BEFA-44BA-11E7-831A-83B4AD28A064, Raemdonck, KoenFW010019993279278010019514740000-0002-9807-4715F77C2766-F0ED-11E1-A9DE-61C894A0A6B4, Declercq, WimWE148010007079550000-0002-8218-2017F463B710-F0ED-11E1-A9DE-61C894A0A6B4, de Beeck, Ken Op, Pfeuty, Benjamin, Stremersch, StephanUGent00007010200180200127902297753363362505EFE062-F0EE-11E1-A9DE-61C894A0A6B4, Riquet, FranckUGent80200162347197963741600482492F7E-2AE5-11E3-A4E0-796A10BDE39D   +10 more
core   +8 more sources

GSDME-dependent pyroptosis signaling pathway in diabetic nephropathy

Cell Death Discovery, 2023
Diabetic nephropathy (DN) is one of the serious chronic microvascular complications of diabetes, and leads to the increased morbidity and mortality in diabetic patients.
Zhi Qi, Chang Liu, Changzhen Ma, Zecheng Jiang, Ruiqing Liu, Liang Yang, Guangru Li, Qiang Wu, Yanna Shen, Yuhang Xie, Xia Wang, Yujie Cui, Lifeng Feng, Shengyu Li, Lin Wang, Aijiao Gao   +15 more
core   +4 more sources

GSDME maintains hematopoietic stem cells by balancing pyroptosis and apoptosis

Blood Science, 2021
. GSDME contains a pore-forming domain at its N-terminal region to execute pyroptosis. Our previous study has reported that forced expression of Gsdme impairs the reconstitution capacity of hematopoietic stem cells (HSCs).
Xiuxiu Yang, Tingting Cong, Hanqing He, Jianwei Wang   +3 more
doaj   +5 more sources

GSDME and its role in cancer : from behind the scenes to the front of the stage

International Journal of Cancer, 2021
: Gasdermin E (GSDME), a gene originally involved in hereditary hearing loss, has been associated with several types of cancer in the last two decades.
Elke De Schutter, De Schutter, Elke, op de Beeck, Ken, Joe Ibrahim, Patrick Pauwels, Ibrahim, Joe, Pauwels, Patrick, Lieselot Croes, Vandenabeele, Peter, Van Camp, Guy, Ken Op de Beeck, Guy Van Camp, Croes, Lieselot, Peter Vandenabeele   +13 more
core   +5 more sources

GSDME in Endothelial Cells: Inducing Vascular Inflammation and Atherosclerosis via Mitochondrial Damage and STING Pathway Activation

Biomedicines, 2023
The initiation of atherosclerotic plaque is characterized by endothelial cell inflammation. In light of gasdermin E’s (GSDME) role in pyroptosis and inflammation, this study elucidates its function in atherosclerosis onset.
Shiyao Xie, Enyong Su, Xiaoyue Song, Junqiang Xue, Peng Yu, Baoli Zhang, Ming Liu, Hong Jiang   +7 more
doaj   +2 more sources

Epithelial-Mesenchymal Transition Induces GSDME Transcriptional Activation for Inflammatory Pyroptosis [PDF]

Frontiers in Cell and Developmental Biology, 2021
GSDME is a newly recognized executor of cellular pyroptosis, and has been recently implicated in tumor growth and immunity. However, knowledge about the molecular regulators underlying GSDME abundance remains limited.
Chenqiang Jia, Chenqiang Jia, Zhuqing Zhang, Zhuqing Zhang, Jun Tang, Mei-Chun Cai, Jingyu Zang, Kaixuan Shi, Yunheng Sun, Jie Wu, Hailei Shi, Weiping Shi, Pengfei Ma, Xiaojing Zhao, Zhuang Yu, Yujie Fu, Guanglei Zhuang, Guanglei Zhuang   +17 more
doaj   +3 more sources