Results 1 to 10 of about 30,930,304 (249)

Targeting gasdermin E in neurodegenerative diseases. [PDF]

Cell Rep Med, 2023
Neel et al. identified pathophysiologic clues linking gasdermin-E (GSDME) with frontotemporal dementia and amyotrophic lateral sclerosis.1 Therapeutic studies targeting GSDME may provide a viable approach for neurodegenerative diseases.
Zhou ZD, Yi LX, Tan EK.
europepmc   +3 more sources

Caspase-1 activates gasdermin A in non-mammals [PDF]

eLife
Gasdermins oligomerize to form pores in the cell membrane, causing regulated lytic cell death called pyroptosis. Mammals encode five gasdermins that can trigger pyroptosis: GSDMA, B, C, D, and E.
Zachary Paul Billman, Stephen Bela Kovacs, Bo Wei, Kidong Kang, Ousmane H Cissé, Edward A Miao   +5 more
doaj   +3 more sources

Caspase 3 proteolytically inactivates gasdermin Ec and inhibits pyroptosis in an early vertebrate

Comparative Immunology Reports
Gasdermin represents a family of pore-forming proteins that execute programmed necrotic cell death, pyroptosis. As an ancient family member, gasdermin E (GSDME) exists ubiquitously from fish to mammals.
Xin Tian, Shuai Jiang
doaj   +1 more source

GSDMD and GSDME exhibit distinct roles in enteric coronavirus PDCoV-induced pyroptosis and inflammatory responses

Journal of Virology
Porcine deltacoronavirus (PDCoV), an emerging enteric coronavirus with zoonotic potential, typically causes intestinal villous epithelial cell damage with inflammation.
Chenyu Li, Yuting Shi, Chunying Xie, Kaiqi Duan, Tong Ding, Xiangfei Xu, Liurong Fang, Yanrong Zhou, Shaobo Xiao   +8 more
doaj   +1 more source

Ubiquitin-independent degradation of Bim blocks macrophage pyroptosis in sepsis-related tissue injury

Cell Death and Disease
Pyroptosis, a typical inflammatory cell death mode, has been increasingly demonstrated to have therapeutic value in inflammatory diseases such as sepsis. However, the mechanisms and therapeutic targets of sepsis remain elusive.
Peilin Shi, Yingying Du, Yunyan Zhang, Bo Yang, Qiujing Guan, Yiming Jing, Hao Tang, Jianguo Tang, Chunhui Yang, Xiaoli Ge, Shihui Shen, Lei Li, Chunrong Wu   +12 more
doaj   +1 more source

Proinflammatory GSDMD activation in live macrophages and DLBCL cells marks cognate interactions and better prognosis

Blood Advances
: Pyroptosis is a form of programmed cell death characterized by the cleavage of the gasdermin (GSDM) family proteins that form pores in the plasma membrane, cell rupture, and the release of proinflammatory cytokines.
Xue Kong, Zijun Y. Xu-Monette, Zhenming Xu, Eric D. Hsi, Xiaoxian Zhao, Hui Yan, Harry Nunns, Kelly Au, Carlo Visco, Alexandar Tzankov, Karen Dybkaer, Shuna Yao, Dehong Wu, Chang Wang, Alexander M. Xu, Zenggang Pan, Benjamin M. Parsons, April Chiu, Wayne Tam, Santiago Montes-Moreno, Fenghuang Zhan, Leon Bernal-Mizrachi, Youli Zu, Shanxiang Zhang, Michael B. Møller, Weina Chen, Qingyan Au, Akil Merchant, Govind Bhagat, Yong Li, Ken H. Young   +30 more
doaj   +1 more source

Neutrophil extracellular traps and pyroptosis: a molecular nexus linking systemic autoimmune diseases to atherosclerosis

Frontiers in Immunology
This review aims to elucidate the molecular mechanisms of neutrophil extracellular traps (NETs) and pyroptosis, exploring their synergistic role as a pathological nexus bridging systemic autoimmune diseases with atherosclerosis.
Yan Du, Lulu Zhang, Yiheng Cheng, Sijie Lu, Ronghua Ou, Xiaojian Deng   +5 more
doaj   +1 more source

Effects of surface-exposed sialic acid and LOS outer core on the ability of native Neisseria meningitidis outer membrane vesicles (nOMVs) to induce cytokine expression and pyroptotic pathways in THP-1-derived macrophages

Scientific Reports
Native outer membrane vesicles (nOMVs) are involved in meningococcal pathogenesis and are used for vaccine production. In this study, macrophages derived from the human monocytic cell line THP-1 were exposed to nOMVs from serogroup B N.
Silvia Caterina Resta, Adelfia Talà, Antonio Baccante, Giovanni Saudino, Pasquale Petruccelli, Vito Di Cioccio, Cecilia Bucci, Pietro Alifano   +7 more
doaj   +1 more source

cGAS activation converges with intracellular acidification to promote STING aggregation and pyroptosis in tumor models

The Journal of Clinical Investigation
The cyclic GMP-AMP synthase (cGAS)/stimulator of IFN genes (STING) pathway is intimately associated with antitumoral immunity; however, the direct involvement of this pathway in tumor cell demise remains elusive. Here, we identified a compound, dodecyl 6-
Li Xiao, Yuan-li Ai, Xiang-yu Mi, Han Liang, Xiang Zhi, Liu-zheng Wu, Qi-tao Chen, Tong Gou, Chao Chen, Bo Zhou, Wen-bin Hong, Lu-ming Yao, Jun-jie Chen, Xianming Deng, Fu-nan Li, Qiao Wu, Hang-zi Chen   +16 more
doaj   +1 more source

Caspase-4/11 promotes hyperlipidemia and chronic kidney disease–accelerated vascular inflammation by enhancing trained immunity

JCI Insight
To determine whether hyperlipidemia and chronic kidney disease (CKD) have a synergy in accelerating vascular inflammation via trained immunity (TI), we performed aortic pathological analysis and RNA-Seq of high-fat diet–fed (HFD-fed) 5/6 nephrectomy CKD (
Yu Sun, Yifan Lu, Lu Liu, Fatma Saaoud, Ying Shao, Keman Xu, Charles Drummer IV, Ramon Cueto, Huimin Shan, Xiaohua Jiang, Huaqing Zhao, Hong Wang, Xiaofeng Yang   +12 more
doaj   +1 more source