Gasdermin E is dispensable for H1N1 influenza virus pathogenesis in mice [PDF]
Microbiology SpectrumTargeting cell death pathways, including pyroptosis and necroptosis, has been shown to mitigate influenza virus infection severity. Here, we examined whether pyroptosis specifically driven by the pore-forming protein gasdermin E (GSDME) is involved in ...
Samuel Speaks +10 more
doaj +6 more sources
Gasdermin E: A Prospective Target for Therapy of Diseases [PDF]
Frontiers in Pharmacology, 2022 Gasdermin E (GSDME) is a member of the gasdermin protein family, which mediates programmed cell death including apoptosis and pyroptosis. Recently, it was suggested that GSDME is activated by chemotherapeutic drugs to stimulate pyroptosis of cancer cells
Xiu-Xiu Liao +3 more
doaj +4 more sources
Gasdermin E in glioblastoma –pyroptosis resistance and tumor-promoting functions [PDF]
Cell Death DiscoveryTreatment of glioblastoma (GB), the most common and most aggressive malignant brain tumor, has made little progress over the past two decades. Despite extensive research on apoptosis and autophagy, necrotic cell death mechanisms like pyroptosis, which ...
Ege Solel +10 more
doaj +4 more sources
Loss of polarity regulators initiates gasdermin-E-mediated pyroptosis in syncytiotrophoblasts [PDF]
Life Science Alliance, 2023 Disruption of atypical protein kinase-C isoforms leads to the initiation of pyroptosis, a form of programmed necrosis, in placental syncytiotrophoblasts at the human maternal–fetal interface.
Khushali Patel +7 more
doaj +4 more sources
Methylcobalamin protects against liver failure via engaging gasdermin E [PDF]
Nature CommunicationsGasdermin E (GSDME) is a pyroptotic cell death effector and a promising target for pyroptotic tissue injury. Here we perform high-throughput screening and demonstrate that methylcobalamin (MeCbl), an endogenous coenzyme form of vitamin B12, is a specific
Wanfeng Xu +14 more
doaj +4 more sources
Oncolytic Parapoxvirus induces Gasdermin E-mediated pyroptosis and activates antitumor immunity [PDF]
Nature Communications, 2023 Oncolytic viruses are able to target tumours and thought to induce apoptosis while remodelling the tumour immune microenvironment. Here authors show in an oncolytic parapoxvirus ovis model that pyroptosis, a highly immunogenic Gasdermin-E-dependent cell ...
Jing Lin +22 more
doaj +4 more sources
BI 2536 induces gasdermin E-dependent pyroptosis in ovarian cancer [PDF]
Frontiers in Oncology, 2022 BackgroundThe frequent emergence of drug resistance to chemotherapy is a major obstacle for the treatment of ovarian cancer. There is a need for novel drugs to fulfill this challenge. Pyroptosis-inducing drugs can inhibit tumor growth.
Jianting Huo +5 more
doaj +4 more sources
Targeting gasdermin E in neurodegenerative diseases. [PDF]
Cell Rep Med, 2023 Neel et al. identified pathophysiologic clues linking gasdermin-E (GSDME) with frontotemporal dementia and amyotrophic lateral sclerosis.1 Therapeutic studies targeting GSDME may provide a viable approach for neurodegenerative diseases.
Zhou ZD, Yi LX, Tan EK.
europepmc +3 more sources
Human Coronavirus 229E Infection Inactivates Pyroptosis Executioner Gasdermin D but Ultimately Leads to Lytic Cell Death Partly Mediated by Gasdermin E [PDF]
VirusesHuman coronavirus 229E (HCoV-229E) is associated with upper respiratory tract infections and generally causes mild respiratory symptoms. HCoV-229E infection can cause cell death, but the molecular pathways that lead to virus-induced cell death as well as
Xavier Martiáñez-Vendrell +5 more
doaj +5 more sources
Gasdermin E (GSDME)—A New Potential Marker of Psoriasis and Its Metabolic Complications: The First Combined Study on Human Serum, Urine and Tissue [PDF]
Cells, 2023 Psoriasis is a frequent and incurable skin disease whose pathogenesis is still not fully understood. It is characterized by immune disturbances leading to hyperproliferation and improper differentiation of keratinocytes.
Julia Nowowiejska +6 more
doaj +2 more sources