Gasdermin E is dispensable for H1N1 influenza virus pathogenesis in mice [PDF]
Microbiology SpectrumTargeting cell death pathways, including pyroptosis and necroptosis, has been shown to mitigate influenza virus infection severity. Here, we examined whether pyroptosis specifically driven by the pore-forming protein gasdermin E (GSDME) is involved in ...
Samuel Speaks +10 more
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Methylcobalamin protects against liver failure via engaging gasdermin E [PDF]
Nature CommunicationsGasdermin E (GSDME) is a pyroptotic cell death effector and a promising target for pyroptotic tissue injury. Here we perform high-throughput screening and demonstrate that methylcobalamin (MeCbl), an endogenous coenzyme form of vitamin B12, is a specific
Wanfeng Xu +14 more
doaj +5 more sources
Oncolytic Parapoxvirus induces Gasdermin E-mediated pyroptosis and activates antitumor immunity [PDF]
Nature Communications, 2023 Oncolytic viruses are able to target tumours and thought to induce apoptosis while remodelling the tumour immune microenvironment. Here authors show in an oncolytic parapoxvirus ovis model that pyroptosis, a highly immunogenic Gasdermin-E-dependent cell ...
Jing Lin +22 more
doaj +5 more sources
Viral sensing by epithelial cells involves PKR- and caspase-3-dependent generation of gasdermin E pores [PDF]
iScience, 2023 Summary: Viral sensing in myeloid cells involves inflammasome activation leading to gasdermin pore formation, cytokine release, and cell death. However, less is known about viral sensing in barrier epithelial cells, which are critical to the innate ...
Coralie Guy +4 more
doaj +4 more sources
Gasdermin E: A Prospective Target for Therapy of Diseases [PDF]
Frontiers in Pharmacology, 2022 Gasdermin E (GSDME) is a member of the gasdermin protein family, which mediates programmed cell death including apoptosis and pyroptosis. Recently, it was suggested that GSDME is activated by chemotherapeutic drugs to stimulate pyroptosis of cancer cells
Xiu-Xiu Liao +3 more
doaj +4 more sources
Gasdermin E: a missing link in muscle regeneration [PDF]
The Journal of Clinical InvestigationSkeletal muscle has the impressive capacity to completely regenerate even after relatively severe injuries in young individuals, but this process is dysregulated in multiple cell types in the microenvironment in numerous diseases and aging. In this issue
Swathy Krishna, Jill A. Rafael-Fortney
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Gasdermin E in glioblastoma –pyroptosis resistance and tumor-promoting functions [PDF]
Cell Death DiscoveryTreatment of glioblastoma (GB), the most common and most aggressive malignant brain tumor, has made little progress over the past two decades. Despite extensive research on apoptosis and autophagy, necrotic cell death mechanisms like pyroptosis, which ...
Ege Solel +10 more
doaj +4 more sources
Protection against post-resuscitation renal injury by Artesunate via inhibition of caspase-3/Gasdermin E -mediated pyroptosis [PDF]
Resuscitation PlusBackground: Post-resuscitation renal injury is the common complication after cardiac arrest and resuscitation. Artesunate (Art) has been confirmed to protect against regional ischemia–reperfusion injuries in multiple organs. This study aimed to determine
Qianqian Wang +4 more
doaj +3 more sources
Loss of polarity regulators initiates gasdermin-E-mediated pyroptosis in syncytiotrophoblasts [PDF]
Life Science Alliance, 2023 Disruption of atypical protein kinase-C isoforms leads to the initiation of pyroptosis, a form of programmed necrosis, in placental syncytiotrophoblasts at the human maternal–fetal interface.
Khushali Patel +7 more
doaj +4 more sources
Gasdermin E deficiency limits inflammation and lung damage during influenza virus infection [PDF]
Cell Death and DiseaseSevere influenza A virus (IAV) infections are associated with hyperinflammation and significant lung damage. Gasdermin E (GSDME) mediates pyroptosis, a lytic and inflammatory type of cell death.
Sarah Rosli +9 more
doaj +3 more sources