Results 11 to 20 of about 12,681 (203)

Gasdermin E: a missing link in muscle regeneration. [PDF]

J Clin Invest
Skeletal muscle has the impressive capacity to completely regenerate even after relatively severe injuries in young individuals, but this process is dysregulated in multiple cell types in the microenvironment in numerous diseases and aging.
Krishna S, Rafael-Fortney JA.
europepmc   +2 more sources

Viral sensing by epithelial cells involves PKR- and caspase-3-dependent generation of gasdermin E pores [PDF]

iScience, 2023
Summary: Viral sensing in myeloid cells involves inflammasome activation leading to gasdermin pore formation, cytokine release, and cell death. However, less is known about viral sensing in barrier epithelial cells, which are critical to the innate ...
Coralie Guy, Marcin Baran, Pau Ribó-Molina, Bernadette G. van den Hoogen, Andrew G. Bowie   +4 more
doaj   +2 more sources

Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration. [PDF]

Neuron, 2023
Mitochondrial dysfunction and axon loss are hallmarks of neurologic diseases. Gasdermin (GSDM) proteins are executioner pore-forming molecules that mediate cell death, yet their roles in the central nervous system (CNS) are not well understood. Here, we find that one GSDM family member, GSDME, is expressed by both mouse and human neurons. GSDME plays a
Neel DV, Basu H, Gunner G, Bergstresser MD, Giadone RM, Chung H, Miao R, Chou V, Brody E, Jiang X, Lee E, Watts ME, Marques C, Held A, Wainger B, Lagier-Tourenne C, Zhang YJ, Petrucelli L, Young-Pearse TL, Chen-Plotkin AS, Rubin LL, Lieberman J, Chiu IM.   +22 more
europepmc   +3 more sources

Prognostic and Immunological Role of Gasdermin E in Pan-Cancer Analysis [PDF]

Frontiers in Oncology, 2021
Despite accumulating cell- or animal-based experiments providing the relationship between Gasdermin E (GSDME) and human diseases, especially in malignant cancers, no pan-cancer analysis about the function of GSMDE in cancer management can be available up
Zheng Zhang, Shuangshuang Zhao, Haizhen Yang, Yanwei Chen, Huahui Feng, Maohui An, Baoding Chen   +6 more
doaj   +3 more sources

Protection against post-resuscitation renal injury by Artesunate via inhibition of caspase-3/Gasdermin E -mediated pyroptosis [PDF]

Resuscitation Plus
Background: Post-resuscitation renal injury is the common complication after cardiac arrest and resuscitation. Artesunate (Art) has been confirmed to protect against regional ischemia–reperfusion injuries in multiple organs. This study aimed to determine
Qianqian Wang, Peng Shen, Wang Wu, Jiangang Zhu, Jiefeng Xu   +4 more
doaj   +2 more sources

Gasdermin E mediates pyroptosis in the progression of hepatocellular carcinoma: a double-edged sword. [PDF]

Gastroenterol Rep (Oxf), 2023
Abstract Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer worldwide. It usually develops due to viral hepatitis or liver cirrhosis. The molecular mechanisms involved in HCC pathogenesis are complex and incompletely understood.
Lu Y, Xu J, Lin H, Zhu M, Li M.
europepmc   +3 more sources

Gasdermin D and Gasdermin E Are Dispensable for Silica-Mediated IL-1β Secretion from Mouse Macrophages. [PDF]

Immunohorizons
Abstract Silica crystals activate the NLRP3 inflammasome in macrophages, resulting in the caspase-1–dependent secretion of the proinflammatory cytokine IL-1β. Caspase-1–mediated cleavage of gasdermin D (GSDMD) triggers the formation of GSDMD pores, which drive pyroptotic cell death and facilitate the rapid release of IL-1β.
Leung J, Chang M, Moore RE, Dagvadorj J, Sutterwala FS, Cassel SL.   +5 more
europepmc   +4 more sources

Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases

Cell Reports, 2021
Summary: Cellular inflammasome activation causes caspase-1 cleavage of the pore-forming protein gasdermin D (GSDMD) with subsequent pyroptotic cell death and cytokine release.
Derek Abbott, Bowen Zhou
exaly   +3 more sources

Duck gasdermin E is a substrate of caspase-3/-7 and an executioner of pyroptosis. [PDF]

Front Immunol, 2022
Gasdermin (GSDM)-mediated cell death is an ancient immune defensive mechanism that plays an essential role in bacteria, fungi, coral, teleost, and mammals. After being cleaved by proteases of hosts or pathogens, amino-terminal (NT) fragment of GSDMs (GSDM-NTs) form pores in the membrane structure of cells, thereby leading to pyroptotic cell death ...
Li H, Wang X, Yu L, Wang J, Cao Y, Ma B, Zhang W.   +6 more
europepmc   +4 more sources

Secondary Necrosis Following Caspase-Activation can Occur Independently of Gasdermin E. [PDF]

Adv Sci (Weinh)
Abstract Regulated necrosis is a known direct consequence of activation of the necroptosis‐ and pyroptosis‐ pathways, but may also result from apoptosis in a process referred to as secondary necrosis. Apoptosis is well understood to be mediated by caspase activation, but the mechanisms that lead to plasma membrane rupture in secondary
Gavali S, Maremonti F, Tonnus W, Gembardt F, Nastassja Schlecht M, Flade K, von Mässenhausen A, Tait SWG, Bornstein SR, Linkermann A.   +9 more
europepmc   +3 more sources