Results 41 to 50 of about 12,681 (203)

Gasdermin E suppresses tumour growth by activating anti-tumour immunity

Nature, 2020
Cleavage of the gasdermin proteins to produce pore-forming amino-terminal fragments causes inflammatory cell death (pyroptosis)1. Gasdermin E (GSDME, also known as DFNA5)-mutated in familial ageing-related hearing loss2-can be cleaved by caspase 3, thereby converting noninflammatory apoptosis to pyroptosis in GSDME-expressing cells3-5. GSDME expression
Zhang, Zhibin, Zhang, Ying, Xia, Shiyu, Kong, Qing, Li, Shunying, Liu, Xing, Junqueira, Caroline, Meza-Sosa, Karla F., Temy Mok, Mo Yin, Ansara, James, Sengupta, Satyaki, Yao, Yandan, Wu, Hao, Lieberman, Judy   +13 more
openaire   +5 more sources

Triclabendazole Induces Pyroptosis by Activating Caspase-3 to Cleave GSDME in Breast Cancer Cells

Frontiers in Pharmacology, 2021
Pyroptosis is a form of programmed cell death, in which gasdermin E (GSDME) plays an important role in cancer cells, which can be induced by activated caspase-3 on apoptotic stimulation.
Liang Yan, Yi Liu, Xue-feng Ma, Dan Hou, Dan Hou, Yu-hui Zhang, Yong Sun, Shan-shan Shi, Tim Forouzanfar, Hai-yan Lin, Jun Fan, Gang Wu, Gang Wu   +12 more
doaj   +1 more source

Gasdermin E deficiency attenuates acute kidney injury by inhibiting pyroptosis and inflammation [PDF]

Cell Death & Disease, 2021
AbstractPyroptosis, one kind of inflammatory regulated cell death, is involved in various inflammatory diseases, including acute kidney injury (AKI). Besides Gasdermin D (GSDMD), GSDME is a newly identified mediator of pyroptosis via the cleavage of caspase-3 generating pyroptotic GSDME-N.
Weiwei Xia, Yuanyuan Li, Mengying Wu, Qianqian Jin, Qian Wang, Shuzhen Li, Songming Huang, Aihua Zhang, Yue Zhang, Zhanjun Jia   +9 more
openaire   +3 more sources

Gasdermin-E-mediated pyroptosis participates in the pathogenesis of Crohn’s disease by promoting intestinal inflammation

Cell Reports, 2021
Summary: Crohn’s disease (CD) is a kind of refractory intestinal inflammatory diseases. Pyroptosis was recently identified as a gasdermin-mediated proinflammatory cell death.
Gao Tan, Chongyang Huang, Jiaye Chen, Bingxia Chen, Fachao Zhi   +4 more
doaj   +1 more source

Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation

Nature Communications, 2019
Gasdermins mediate lytic cell death by forming pores in the plasma membrane. Here the authors show that gasdermins also permeabilize mitochondrial membrane, thereby facilitating intrinsic apoptosis pathway, downstream of apoptotic (Gasdermin E) and ...
Corey Rogers, Dan A. Erkes, Alexandria Nardone, Andrew E. Aplin, Teresa Fernandes-Alnemri, Emad S. Alnemri   +5 more
doaj   +1 more source

Induction of Pyroptosis and Its Implications in Cancer Management

Frontiers in Oncology, 2019
Pyroptosis is a gasdermins mediated programmed cell death, which has been widely studied in inflammatory disease models. Recently, there are growing evidences that pyroptosis can be chemically induced in cancer cells without any bacterial or viral ...
Yan-Yang Wang, Yan-Yang Wang, Xin-Lan Liu, Ren Zhao, Ren Zhao   +4 more
doaj   +1 more source

Oncolytic virus-delivered GSDME: Unlocking pyroptosis to improve dendritic cell function and amplify cytotoxic T cell response

Molecular Therapy: Oncology
Oncolytic virotherapy is a promising strategy for advanced cancers, but clinical success remains limited. Combining oncolytic viruses with immunogenic cell death modalities offers a potential solution.
Sabrina Schneider, Theresa Schwaiger, Joelle Kröll, Ioannes Basbas, Fabian Martin, Dongyue Xin, Elke Podgorschek, Ilona Arnkil, Marlies Glatz, Melissa Mayr, Monika Petersson, Stefan Scheidl, Stefan Schneeberger, Krishna Das, Bart Spiesschaert, Christian Mandl, Sebastian Carotta, Christiane B. Knobbe-Thomsen, Knut Elbers, Tobias Nolden   +19 more
doaj   +1 more source

Pyroptosis: a double-edged sword in lung cancer and other respiratory diseases

Cell Communication and Signaling
Pyroptosis is an active cell death process mediated by gasdermin family proteins including Gasdermin A (GSDMA), Gasdermin B (GSDMB), Gasdermin C (GSDMC), Gasdermin D (GSDMD), Gasdermin E (GSDME, DFNA5), and DFNB59.
Xiao Liang, Ya Qin, Dan Wu, Qiong Wang, Hongshuai Wu   +4 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Light‐Activatable Nitric Oxide Release via Intramolecular Electron Transfer for Tumor Pyroptosis Induction

Advanced Science, EarlyView.
This work proposes a novel strategy to fabricate unimolecular pyroptosis photoinitiators activated by deep‐red light at low light doses. It relies on a photosensitization mechanism to trigger nitric oxide (NO) release from benzisothiadiazole‐based N‐nitrosanilines without modification of nitro moieties, thereby boosting pyroptosis‐mediated ...
Chuangxin Zhang, Ruipeng Li, Yunxia Wang, Feng Liu, Liheng Feng   +4 more
wiley   +1 more source