Results 41 to 50 of about 30,930,304 (249)

Zika virus causes placental pyroptosis and associated adverse fetal outcomes by activating GSDME

eLife, 2022
Zika virus (ZIKV) can be transmitted from mother to fetus during pregnancy, causing adverse fetal outcomes. Several studies have indicated that ZIKV can damage the fetal brain directly; however, whether the ZIKV-induced maternal placental injury ...
Zikai Zhao, Qi Li, Usama Ashraf, Mengjie Yang, Wenjing Zhu, Jun Gu, Zheng Chen, Changqin Gu, Youhui Si, Shengbo Cao, Jing Ye   +10 more
doaj   +1 more source

Arsenic trioxide induces gasdermin E mediated pyroptosis in astroglioma cells [PDF]

Translational Cancer Research, 2020
Arsenic trioxide (ATO) has been proved useful for the treatment of acute promyelocytic leukemia (APL). Apoptosis is the result of the cytotoxic effect of ATO, apoptotic mediated cell death confirmed by DNA fragmentation and Annexin V staining. Although signaling associated with ATO-induced apoptosis has been well defined, it is still unknown whether ...
Wang, Jingling, Zhan, Linghui, Cai, Zheng, Liu, Xiaomei, Wang, Junsheng, Zhong, Huarong, Huang, Xianwei, Lai, Qinxiao, Tan, Qingzhao, Xiu, Yibin, Yang, Daowei, Min, Xianghui   +11 more
openaire   +2 more sources

Gasdermin E 매개 칼슘 이온이 세포고사 엑소좀 생합성에 미치는 영향

, 2023
MasterⅠ. 서론 1 Ⅱ. 재료 및 방법 9 A. 세포, 항체 9 B. PCR and In-fusion 클로닝 9 C. Lentiviral vector 형질주입 10 D. CRISPR / Cas9 녹아웃 10 E. PiggyBac transposon system 11 F. 웨스턴 블롯 12 G. Calcium fluorescence luminometer 13 H.
강, 대욱
core   +1 more source

New insights into the evolutionary dynamic and lineage divergence of gasdermin E in metazoa

Frontiers in Cell and Developmental Biology, 2022
Gasdermin (GSDM) is a family of pore-forming proteins that induce pyroptosis. To date, the origin and evolution of GSDM in Metazoa remain elusive. Here, we found that GSDM emerged early in Placozoa but is absent in a large number of invertebrates. In the lower vertebrate, fish, three types of GSDME, i.e., GSDMEa, GSDMEb, and a previously unreported ...
Zihao Yuan, Zihao Yuan, Shuai Jiang, Shuai Jiang, Kunpeng Qin, Kunpeng Qin, Kunpeng Qin, Li Sun, Li Sun, Li Sun   +9 more
openaire   +3 more sources

GSDME-Dependent Incomplete Pyroptosis Permits Selective IL-1α Release under Caspase-1 Inhibition

iScience, 2020
Summary: Pyroptosis is a form of regulated cell death that is characterized by gasdermin processing and increased membrane permeability. Caspase-1 and caspase-11 have been considered to be essential for gasdermin D processing associated with inflammasome
Emi Aizawa, Tadayoshi Karasawa, Sachiko Watanabe, Takanori Komada, Hiroaki Kimura, Ryo Kamata, Homare Ito, Erika Hishida, Naoya Yamada, Tadashi Kasahara, Yoshiyuki Mori, Masafumi Takahashi   +11 more
doaj   +1 more source

Gasdermin E mediates photoreceptor damage by all-trans-retinal in the mouse retina [PDF]

Journal of Biological Chemistry, 2022
The breakdown of all-trans-retinal (atRAL) clearance is closely associated with photoreceptor cell death in dry age-related macular degeneration (AMD) and autosomal recessive Stargardt's disease (STGD1), but its mechanisms remain elusive. Here, we demonstrate that activation of gasdermin E (GSDME) but not gasdermin D promotes atRAL-induced ...
Cai, Binxiang, Liao, Chunyan, He, Danxue, Chen, Jingmeng, Han, Jiahuai, Lu, Jiaying, Qin, Kaiqi, Liang, Wenxu, Wu, Xiaoling, Liu, Zuguo, Wu, Yalin   +10 more
openaire   +2 more sources

Posttranslational and therapeutic control of gasdermin-mediated pyroptosis and inflammation [PDF]

, 2021
Pyroptosis is a proinflammatory form of cell death, mediated by membrane pore-forming proteins called gasdermins. Gasdermin pores allow the release of the pro-inflammatory cytokines IL-1β and IL-18 and cause cell swelling and cell lysis leading to ...
Chen, Kaiwen W., Bezbradica, Jelena S, Bezbradica, Jelena S., Fischer, Fabian A, Chen, Kaiwen W, Fischer, Fabian A.   +5 more
core   +1 more source

Raptinal Induces Gasdermin E-Dependent Pyroptosis in Naïve and Therapy-Resistant Melanoma. [PDF]

Mol Cancer Res, 2022
Abstract Lack of response and acquired resistance continue to be limitations of targeted and immune-based therapies. Pyroptosis is an inflammatory form of cell death characterized by the release of inflammatory damage-associated molecular patterns (DAMP) and cytokines via gasdermin (GSDM ...
Vernon M, Wilski NA, Kotas D, Cai W, Pomante D, Tiago M, Alnemri ES, Aplin AE.   +7 more
europepmc   +3 more sources

A Comparative Review of Pyroptosis in Mammals and Fish

Journal of Inflammation Research, 2022
Zixi Song,* Jiahong Zou,* Mengya Wang, Zhenwei Chen, Qingchao Wang Engineering Research Center of Green Development for Conventional Aquatic Biological Industry in the Yangtze River Economic Belt, Ministry of Education, College of Fisheries ...
Song Z, Zou J, Wang M, Chen Z, Wang Q
doaj  

Gasdermin E deficiency attenuates acute kidney injury by inhibiting pyroptosis and inflammation [PDF]

Cell Death & Disease, 2021
AbstractPyroptosis, one kind of inflammatory regulated cell death, is involved in various inflammatory diseases, including acute kidney injury (AKI). Besides Gasdermin D (GSDMD), GSDME is a newly identified mediator of pyroptosis via the cleavage of caspase-3 generating pyroptotic GSDME-N.
Weiwei Xia, Yuanyuan Li, Mengying Wu, Qianqian Jin, Qian Wang, Shuzhen Li, Songming Huang, Aihua Zhang, Yue Zhang, Zhanjun Jia   +9 more
openaire   +3 more sources