Neobractatin and Trametinib Synergistically Induce Apoptosis and Gasdermin E‐Dependent Pyroptosis in Pancreatic Cancer Cells [PDF]
MedCommMutations in mitogen‐activated protein kinase kinase (MEK) are prevalent in pancreatic ductal adenocarcinoma (PDAC), but many MEK inhibitors inadvertently activate protein kinase B (AKT).
Jiaqi Tan +7 more
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BI 2536 induces gasdermin E-dependent pyroptosis in ovarian cancer
Frontiers in Oncology, 2022 BackgroundThe frequent emergence of drug resistance to chemotherapy is a major obstacle for the treatment of ovarian cancer. There is a need for novel drugs to fulfill this challenge. Pyroptosis-inducing drugs can inhibit tumor growth.
Jianting Huo +5 more
doaj +3 more sources
Gasdermin-E-mediated pyroptosis drives immune checkpoint inhibitor-associated myocarditis via cGAS-STING activation [PDF]
Nature CommunicationsImmune checkpoint inhibitor (ICI)-induced myocarditis involves intensive immune/inflammation activation; however, its molecular basis is unclear.
Si-Jia Sun +17 more
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Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration. [PDF]
Neuron, 2023 Mitochondrial dysfunction and axon loss are hallmarks of neurologic diseases. Gasdermin (GSDM) proteins are executioner pore-forming molecules that mediate cell death, yet their roles in the central nervous system (CNS) are not well understood. Here, we find that one GSDM family member, GSDME, is expressed by both mouse and human neurons. GSDME plays a
Neel DV +22 more
europepmc +3 more sources
NEDD 4 Pyre-fighters to extinguish inflammation: NEDD4L ubiquitinates Gasdermin D and Gasdermin E to dampen pyroptosis. [PDF]
Cell Death DifferGulshan K.
europepmc +3 more sources
Genes and Diseases, 2023 Inflammatory bowel disease (IBD) is a chronic relapsing gastrointestinal disorder, while the treatment effect is not satisfactory. Immune responsive gene 1 (IRG1) is a highly expressed gene in macrophage in response to inflammatory response and catalyzes
Wenchang Yang +8 more
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Gasdermin D and Gasdermin E Are Dispensable for Silica-Mediated IL-1β Secretion from Mouse Macrophages. [PDF]
ImmunohorizonsAbstract Silica crystals activate the NLRP3 inflammasome in macrophages, resulting in the caspase-1–dependent secretion of the proinflammatory cytokine IL-1β. Caspase-1–mediated cleavage of gasdermin D (GSDMD) triggers the formation of GSDMD pores, which drive pyroptotic cell death and facilitate the rapid release of IL-1β.
Leung J +5 more
europepmc +4 more sources
Duck gasdermin E is a substrate of caspase-3/-7 and an executioner of pyroptosis. [PDF]
Front Immunol, 2022 Gasdermin (GSDM)-mediated cell death is an ancient immune defensive mechanism that plays an essential role in bacteria, fungi, coral, teleost, and mammals. After being cleaved by proteases of hosts or pathogens, amino-terminal (NT) fragment of GSDMs (GSDM-NTs) form pores in the membrane structure of cells, thereby leading to pyroptotic cell death ...
Li H +6 more
europepmc +4 more sources
Pyroptosis, inflammasome, and gasdermins in tumor immunity
Innate Immunity, 2023 The gasdermins (GSDM), a family of pore-forming proteins, consist of gasdermin A (GSDMA), gasdermin B (GSDMB), gasdermin C (GSDMC), gasdermin D (GSDMD), gasdermin E (GSDME) and DFNB59 (Pejvakin (PJVK)) in humans.
Xiaohu Ouyang +5 more
doaj +1 more source
Pyroptosis and degenerative diseases of the elderly
Cell Death and Disease, 2023 Pyroptosis is a recently described mechanism of programmed cell death mediated by proteins of the gasdermin family. Widely recognized signaling cascades include the classical, non-classical, caspase-3-dependent gasdermin E and caspase-8-dependent ...
Jiamin Zhou +8 more
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