Results 31 to 40 of about 12,681 (203)
Pyroptosis, inflammasome, and gasdermins in tumor immunity
Innate Immunity, 2023 The gasdermins (GSDM), a family of pore-forming proteins, consist of gasdermin A (GSDMA), gasdermin B (GSDMB), gasdermin C (GSDMC), gasdermin D (GSDMD), gasdermin E (GSDME) and DFNB59 (Pejvakin (PJVK)) in humans.
Xiaohu Ouyang +5 more
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Pyroptosis and degenerative diseases of the elderly
Cell Death and Disease, 2023 Pyroptosis is a recently described mechanism of programmed cell death mediated by proteins of the gasdermin family. Widely recognized signaling cascades include the classical, non-classical, caspase-3-dependent gasdermin E and caspase-8-dependent ...
Jiamin Zhou +8 more
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An ancient defense mechanism: Conservation of gasdermin-mediated pyroptosis.
PLoS Biology, 2023 The gasdermins are a family of pore-forming proteins involved in various cellular processes such as cell death and inflammation. A new study in PLOS Biology explores the evolutionary history of gasdermins across metazoans, highlighting the conservation ...
Chengliang Wang, Jianbin Ruan
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Zika virus causes placental pyroptosis and associated adverse fetal outcomes by activating GSDME
eLife, 2022 Zika virus (ZIKV) can be transmitted from mother to fetus during pregnancy, causing adverse fetal outcomes. Several studies have indicated that ZIKV can damage the fetal brain directly; however, whether the ZIKV-induced maternal placental injury ...
Zikai Zhao +10 more
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Arsenic trioxide induces gasdermin E mediated pyroptosis in astroglioma cells [PDF]
Translational Cancer Research, 2020 Arsenic trioxide (ATO) has been proved useful for the treatment of acute promyelocytic leukemia (APL). Apoptosis is the result of the cytotoxic effect of ATO, apoptotic mediated cell death confirmed by DNA fragmentation and Annexin V staining. Although signaling associated with ATO-induced apoptosis has been well defined, it is still unknown whether ...
Wang, Jingling +11 more
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Gasdermin E mediates photoreceptor damage by all-trans-retinal in the mouse retina [PDF]
Journal of Biological Chemistry, 2022 The breakdown of all-trans-retinal (atRAL) clearance is closely associated with photoreceptor cell death in dry age-related macular degeneration (AMD) and autosomal recessive Stargardt's disease (STGD1), but its mechanisms remain elusive. Here, we demonstrate that activation of gasdermin E (GSDME) but not gasdermin D promotes atRAL-induced ...
Cai, Binxiang +10 more
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GSDME-Dependent Incomplete Pyroptosis Permits Selective IL-1α Release under Caspase-1 Inhibition
iScience, 2020 Summary: Pyroptosis is a form of regulated cell death that is characterized by gasdermin processing and increased membrane permeability. Caspase-1 and caspase-11 have been considered to be essential for gasdermin D processing associated with inflammasome
Emi Aizawa +11 more
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A Comparative Review of Pyroptosis in Mammals and Fish
Journal of Inflammation Research, 2022 Zixi Song,* Jiahong Zou,* Mengya Wang, Zhenwei Chen, Qingchao Wang Engineering Research Center of Green Development for Conventional Aquatic Biological Industry in the Yangtze River Economic Belt, Ministry of Education, College of Fisheries ...
Song Z, Zou J, Wang M, Chen Z, Wang Q
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Reconstitution of human pyroptotic cell death in Saccharomyces cerevisiae
Scientific Reports, 2023 Pyroptosis is a lytic form of programmed cell death induced by the activation of gasdermins. The precise mechanism of gasdermin activation by upstream proteases remains incompletely understood.
Yanhao Ji, Christine J. Hawkins
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Biomolecules, 2023 Background: Gasdermin D, a molecule downstream of the nucleotide-binding oligomerization domain-like receptor family pyrin domain containing inflammasome, forms the membrane pore for the secretion of interleukin (IL)-1β and IL-18, and also mediates ...
Jia Guo +8 more
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