Human Coronavirus 229E Infection Inactivates Pyroptosis Executioner Gasdermin D but Ultimately Leads to Lytic Cell Death Partly Mediated by Gasdermin E [PDF]
VirusesHuman coronavirus 229E (HCoV-229E) is associated with upper respiratory tract infections and generally causes mild respiratory symptoms. HCoV-229E infection can cause cell death, but the molecular pathways that lead to virus-induced cell death as well as
Xavier Martiáñez-Vendrell +5 more
doaj +5 more sources
Gasdermin E (GSDME)—A New Potential Marker of Psoriasis and Its Metabolic Complications: The First Combined Study on Human Serum, Urine and Tissue [PDF]
Cells, 2023 Psoriasis is a frequent and incurable skin disease whose pathogenesis is still not fully understood. It is characterized by immune disturbances leading to hyperproliferation and improper differentiation of keratinocytes.
Julia Nowowiejska +6 more
doaj +2 more sources
BMC Biology, 2022 Background Gasdermins are ancient (>500million-years-ago) proteins, constituting a family of pore-forming proteins that allow the release of intracellular content including proinflammatory cytokines.
Diego Angosto-Bazarra +5 more
doaj +2 more sources
Prognostic and Immunological Role of Gasdermin E in Pan-Cancer Analysis [PDF]
Frontiers in Oncology, 2021 Despite accumulating cell- or animal-based experiments providing the relationship between Gasdermin E (GSDME) and human diseases, especially in malignant cancers, no pan-cancer analysis about the function of GSMDE in cancer management can be available up
Zheng Zhang +6 more
doaj +3 more sources
An ancient defense mechanism: Conservation of gasdermin-mediated pyroptosis.
PLoS Biology, 2023 The gasdermins are a family of pore-forming proteins involved in various cellular processes such as cell death and inflammation. A new study in PLOS Biology explores the evolutionary history of gasdermins across metazoans, highlighting the conservation ...
Chengliang Wang, Jianbin Ruan
doaj +2 more sources
Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation [PDF]
Nature Communications, 2019 Gasdermins mediate lytic cell death by forming pores in the plasma membrane. Here the authors show that gasdermins also permeabilize mitochondrial membrane, thereby facilitating intrinsic apoptosis pathway, downstream of apoptotic (Gasdermin E) and ...
Corey Rogers +5 more
doaj +3 more sources
Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases
Cell Reports, 2021 Summary: Cellular inflammasome activation causes caspase-1 cleavage of the pore-forming protein gasdermin D (GSDMD) with subsequent pyroptotic cell death and cytokine release.
Derek Abbott, Bowen Zhou
exaly +3 more sources
Secondary Necrosis Following Caspase-Activation can Occur Independently of Gasdermin E. [PDF]
Adv Sci (Weinh)Regulated necrosis is a known direct consequence of activation of the necroptosis‐ and pyroptosis‐ pathways, but may also result from apoptosis in a process referred to as secondary necrosis.
Gavali S +9 more
europepmc +4 more sources
BiologyHidradenitis suppurativa (HS) is a debilitating inflammatory skin condition with unclear underlying mechanisms. Recent studies suggest pyroptosis, a highly inflammatory form of programmed cell death, could significantly contribute to the disease process.
Kinga Tyczyńska +7 more
doaj +2 more sources
, 2022 Supplementary Figure from Raptinal Induces Gasdermin E–Dependent Pyroptosis in Naïve and Therapy-Resistant ...
Andrew E. Aplin (14940036) +7 more
core +7 more sources