Results 1 to 10 of about 15,644 (115)

Posttranslational and Therapeutic Control of Gasdermin-Mediated Pyroptosis and Inflammation

Frontiers in Immunology, 2021
Pyroptosis is a proinflammatory form of cell death, mediated by membrane pore-forming proteins called gasdermins. Gasdermin pores allow the release of the pro-inflammatory cytokines IL-1β and IL-18 and cause cell swelling and cell lysis leading to ...
Kaiwen W Chen, Fabian Alexander Fischer, Jelena S Bezbradica   +2 more
exaly   +3 more sources

Vastly different energy landscapes of the membrane insertions of monomeric gasdermin D and A3 [PDF]

Communications Chemistry
Gasdermin D and gasdermin A3 belong to the same family of pore-forming proteins and executors of pyroptosis, a form of programmed cell death. To unveil the process of their pore formation, we examine the energy landscapes upon insertion of the gasdermin ...
Viktoria Korn, Kristyna Pluhackova
doaj   +2 more sources

Investigation of the effect of serum gasdermin d levels on clinical course and mortality in patients with covid-19 [PDF]

BMC Infectious Diseases
Background Cytokine storm is among the pathogenetic mechanisms in patients with severe Coronavirus Disease 2019 (COVID-19). Pyroptosis, a form of programmed cell death, is thought to play an important role in cytokine storms.
Merve Turker Isik, Kubra Demir Onder, Yesim Cekin   +2 more
doaj   +2 more sources

Cyclodextrin attenuates atherosclerosis by diminishing gasdermin D (GSDMD)-mediated pyroptosis [PDF]

Scientific Reports
Pyroptosis, a programmed form of cell death, typically increases during the atherosclerosis development. Cyclodextrins are oligosaccharides with anti-atherosclerotic properties.
Mohammad Ismail Hajary Sagor, Qiuran Wang, Junshu Wang, Guili Lian, Yan Yan, Huibin Tang, Gufeng Gao, Huakan Lin, Liangdi Xie   +8 more
doaj   +2 more sources

Gasdermin D mutation protects against renal ischemia reperfusion injury [PDF]

Physiological Reports
Pyroptosis, the most inflammatory form of cell death, is dependent on membrane pore formation governed by the assembly of cleaved Gasdermin D (GSDMD).
Jennifer S. Y. Li, Aadhar Moudgil, Daniel N. Meijles, Karli Shaw, Sohel M. Julovi, Katie Trinh, Stephen I. Alexander, Natasha M. Rogers   +7 more
doaj   +2 more sources

Gasdermin D: A potential mediator and prognostic marker of bladder cancer

Frontiers in Molecular Biosciences, 2022
Background: Bladder cancer is considered one of the commonest widespread cancers, its presentation ranges from non-muscle invasive form to being muscle-invasive. The gasdermin family of proteins consists of six proteins.
Randa El-Gamal, Randa El-Gamal, Mona Abdelrahim, Mohamed El-Sherbiny, Eman T. Enan, Mohammad El-Nablaway, Mohammad El-Nablaway   +6 more
doaj   +1 more source

Gasdermin D in pyroptosis

Acta Pharmaceutica Sinica B, 2021
Pyroptosis is the process of inflammatory cell death. The primary function of pyroptosis is to induce strong inflammatory responses that defend the host against microbe infection.
Brandon E. Burdette, Ashley N. Esparza, Hua Zhu, Shanzhi Wang   +3 more
doaj   +1 more source

DL-3-n-Butylphthalide Attenuates Myocardial Hypertrophy by Targeting Gasdermin D and Inhibiting Gasdermin D Mediated Inflammation

Frontiers in Pharmacology, 2021
Pressure overload leads to a hypertrophic milieu that produces deleterious cardiac dysfunction. Inflammation is a key pathophysiological mechanism underpinning myocardial hypertrophy.
Bingjiang Han, Jiajun Xu, Xiaowen Shi, Zhanxiong Zheng, Fengjie Shi, Fenfen Jiang, Jibo Han   +6 more
doaj   +1 more source

Caspase-11-Gasdermin D-Mediated Pyroptosis Is Involved in the Pathogenesis of Atherosclerosis

Frontiers in Pharmacology, 2021
Background: Pyroptosis is a form of cell death triggered by proinflammatory signals. Recent studies have reported that oxidized phospholipids function as caspase-11 agonists to induce noncanonical inflammasome activation in immune cells. As the levels of
Mengqing Jiang, Xuejing Sun, Suzhen Liu, Yan Tang, Yunming Shi, Yuanyuan Bai, Yujie Wang, Qiong Yang, Qize Yang, Weihong Jiang, Hong Yuan, Qixia Jiang, Jingjing Cai, Jingjing Cai   +13 more
doaj   +1 more source

Gasdermin-D activation promotes NLRP3 activation and host resistance to Leishmania infection

Nature Communications, 2023
Here, de Sá et al. show that Gasdermin-D is transiently activated in Leishmania-infected macrophages and promotes NLRP3 inflammasome activation, but not cell death.
Keyla S. G. de Sá, Luana A. Amaral, Tamara S. Rodrigues, Adriene Y. Ishimoto, Warrison A. C. de Andrade, Leticia de Almeida, Felipe Freitas-Castro, Sabrina S. Batah, Sergio C. Oliveira, Mônica T. Pastorello, Alexandre T. Fabro, Dario S. Zamboni   +11 more
doaj   +1 more source