Acta Pharmaceutica Sinica B, 2021 Pyroptosis is the process of inflammatory cell death. The primary function of pyroptosis is to induce strong inflammatory responses that defend the host against microbe infection.
Brandon E. Burdette +3 more
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Gasdermin D mutation protects against renal ischemia reperfusion injury [PDF]
Physiological ReportsPyroptosis, the most inflammatory form of cell death, is dependent on membrane pore formation governed by the assembly of cleaved Gasdermin D (GSDMD).
Jennifer S. Y. Li +7 more
doaj +3 more sources
Molecular mechanism of bovine Gasdermin D-mediated pyroptosis
Veterinary ResearchPyroptosis is a form of programmed cell death characterized by cell swelling, pore formation in the plasma membrane, lysis, and releases of cytoplasmic contents.
Zhendong Ge +11 more
doaj +4 more sources
Gasdermin D: the long-awaited executioner of pyroptosis [PDF]
Cell Research, 2015 Inflammatory caspases drive a lytic form of cell death called pyroptosis in response to microbial infection and endogenous damage-associated signals.
Si Ming Man +3 more
core +3 more sources
DL-3-n-Butylphthalide Attenuates Myocardial Hypertrophy by Targeting Gasdermin D and Inhibiting Gasdermin D Mediated Inflammation [PDF]
Frontiers in Pharmacology, 2021 Pressure overload leads to a hypertrophic milieu that produces deleterious cardiac dysfunction. Inflammation is a key pathophysiological mechanism underpinning myocardial hypertrophy.
Bingjiang Han +6 more
doaj +3 more sources
Vastly different energy landscapes of the membrane insertions of monomeric gasdermin D and A3
Communications ChemistryGasdermin D and gasdermin A3 belong to the same family of pore-forming proteins and executors of pyroptosis, a form of programmed cell death. To unveil the process of their pore formation, we examine the energy landscapes upon insertion of the gasdermin ...
Viktoria Korn, Kristyna Pluhackova
doaj +2 more sources
Etoposide Treatment of Cancer Cell Lines Results in Nuclear Localisation of Cleaved Gasdermin D
European Journal of BiologyObjective: Overcoming resistance to apoptosis is one of the main goals of cancer treatment. Subversion of apoptosis to pyroptosis, an inflammatory cell death mediated by Gasdermin family members, was previously proposed as an alternative strategy for ...
Soukaina Imlilss +3 more
doaj +2 more sources
Posttranslational and Therapeutic Control of Gasdermin-Mediated Pyroptosis and Inflammation [PDF]
Frontiers in Immunology, 2021 Pyroptosis is a proinflammatory form of cell death, mediated by membrane pore-forming proteins called gasdermins. Gasdermin pores allow the release of the pro-inflammatory cytokines IL-1β and IL-18 and cause cell swelling and cell lysis leading to ...
Fabian A. Fischer +2 more
doaj +2 more sources
Gasdermin D pore-forming activity is redox-sensitive
Cell Reports, 2023 Summary: Reactive oxygen species (ROS) regulate the activities of inflammasomes, which are innate immune signaling organelles that induce pyroptosis. The mechanisms by which ROS control inflammasome activities are unclear and may be multifaceted. Herein,
Pascal Devant +8 more
doaj +3 more sources
The Role of Gasdermin-D-Mediated Pyroptosis in Organ Injury and Its Therapeutic Implications
Organogenesis, 2023 Gasdermin-D (GSDMD) belongs to the Gasdermin family (GSDM), which are pore-forming effector proteins that facilitate inflammatory cell death, also known as pyroptosis.
Joud Mulla +2 more
doaj +2 more sources