Results 11 to 20 of about 15,764 (222)
Gasdermin D pore-forming activity is redox-sensitive
Cell Reports, 2023 Summary: Reactive oxygen species (ROS) regulate the activities of inflammasomes, which are innate immune signaling organelles that induce pyroptosis. The mechanisms by which ROS control inflammasome activities are unclear and may be multifaceted. Herein,
Pascal Devant +8 more
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Indirect regulation of HMGB1 release by gasdermin D [PDF]
Nature Communications, 2020 HMGB1 is an inflammatory mediator released by a variety of cell types. Here, the authors show that unlike IL-1β, HMGB1 is released non-specifically following cell lysis.
Allen Volchuk +4 more
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Caspase-1 initiates apoptosis in the absence of gasdermin D [PDF]
Nature Communications, 2019 In inflammasomes, caspase-1 activation leads to pyroptosis mediated by gasdermin D, but cells lacking gasdermin-D still initiate caspase-dependent cell death. Here, Tsuchiya et al. show that these cells undergo Bid- and caspase-3-dependent apoptosis.
Kohsuke Tsuchiya +14 more
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Gasdermin D-mediated pyroptosis: mechanisms, diseases, and inhibitors
Frontiers in Immunology, 2023 Gasdermin D (GSDMD)-mediated pyroptosis and downstream inflammation are important self-protection mechanisms against stimuli and infections. Hosts can defend against intracellular bacterial infections by inducing cell pyroptosis, which triggers the ...
Zhen Dai +5 more
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Targeting gasdermin D and neutrophil mobilization for cardioprotection
Metabolism Open, 2021 Maria Dalamaga, Junli Liu
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Gasdermin D and Beyond – Gasdermin-mediated Pyroptosis in Bacterial Infections
Journal of Molecular Biology, 2022 The discovery of pyroptosis and its subsequent implications in infection and immunity has uncovered a new angle of host-defence against pathogen assault. At its most simple, gasdermin-mediated pyroptosis in bacterial infection would be expected to remove pathogens from the relative safety of the cytosol or pathogen containing vacuole/phagosome whilst ...
Lee M, Booty, Clare E, Bryant
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The Roles of Gasdermin D in Coronavirus Infection and Evasion [PDF]
Frontiers in Microbiology, 2021 Pyroptosis is lytic, programmed cell death and plays a critical role against microbial invasion, functioning as an innate immune effector mechanism. The pore-forming protein gasdermin D (GSDMD), a member of gasdermin family proteins, is a primary effector of pyroptosis.
Xiang Liu, Shihao Ding, Pinghuang Liu
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Molecular mechanism of bovine Gasdermin D-mediated pyroptosis
Veterinary ResearchPyroptosis is a form of programmed cell death characterized by cell swelling, pore formation in the plasma membrane, lysis, and releases of cytoplasmic contents.
Zhendong Ge +11 more
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E3 ubiquitin ligase SYVN1 is a key positive regulator for GSDMD-mediated pyroptosis
Cell Death and Disease, 2022 Gasdermin D (GSDMD) participates in the activation of inflammasomes and pyroptosis. Meanwhile, ubiquitination strictly regulates inflammatory responses. However, how ubiquitination regulates Gasdermin D activity is not well understood.
Yuhua Shi +8 more
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Autophagy May Allow a Cell to Forbear Pyroptosis When Confronted With Cytosol-Invasive Bacteria
Frontiers in Immunology, 2022 Inflammatory caspases detect cytosol-invasive Gram-negative bacteria by monitoring for the presence of LPS in the cytosol. This should provide defense against the cytosol-invasive Burkholderia and Shigella species by lysing the infected cell via ...
Carissa K. Harvest +6 more
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