Results 21 to 30 of about 15,764 (222)
Genes and Diseases, 2023 Inflammatory bowel disease (IBD) is a chronic relapsing gastrointestinal disorder, while the treatment effect is not satisfactory. Immune responsive gene 1 (IRG1) is a highly expressed gene in macrophage in response to inflammatory response and catalyzes
Wenchang Yang +8 more
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Gasdermin D: the long-awaited executioner of pyroptosis [PDF]
Cell Research, 2015 Inflammatory caspases drive a lytic form of cell death called pyroptosis in response to microbial infection and endogenous damage-associated signals. Two studies now demonstrate that cleavage of the substrate gasdermin D by inflammatory caspases necessitates eventual pyroptotic demise of a cell.
Si Ming, Man, Thirumala-Devi, Kanneganti
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‘Hints’ in the killer protein gasdermin D: unveiling the secrets of gasdermins driving cell death [PDF]
Cell Death & Differentiation, 2017 Pyroptosis is a lytic form of cell death distinguished from apoptosis, ferroptosis, necrosis, necroptosis, NETosis, oncosis, pyronecrosis and autophagy. Proinflammatory caspases cleave a gasdermin D (GSDMD) protein to generate a 31 kDa N-terminal domain.
Qiu, Shiqiao, Liu, Jing, Xing, Feiyue
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Gasdermin D is the only Gasdermin that provides protection against acute Salmonella gut infection in mice [PDF]
Proceedings of the National Academy of Sciences, 2023 Gasdermins (GSDMs) share a common functional domain structure and are best known for their capacity to form membrane pores. These pores are hallmarks of a specific form of cell death called pyroptosis and mediate the secretion of pro-inflammatory cytokines such as interleukin 1β (IL1β) and interleukin 18 (IL18). Thereby, Gasdermins
Fattinger, Stefan A. +16 more
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iScience, 2023 Summary: Viral sensing in myeloid cells involves inflammasome activation leading to gasdermin pore formation, cytokine release, and cell death. However, less is known about viral sensing in barrier epithelial cells, which are critical to the innate ...
Coralie Guy +4 more
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Pyroptosis, inflammasome, and gasdermins in tumor immunity
Innate Immunity, 2023 The gasdermins (GSDM), a family of pore-forming proteins, consist of gasdermin A (GSDMA), gasdermin B (GSDMB), gasdermin C (GSDMC), gasdermin D (GSDMD), gasdermin E (GSDME) and DFNB59 (Pejvakin (PJVK)) in humans.
Xiaohu Ouyang +5 more
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IL-36γ is secreted through an unconventional pathway using the Gasdermin D and P2X7R membrane pores
Frontiers in Immunology, 2022 Mucosal innate immunity functions as the first line of defense against invading pathogens. Members of the IL-1 family are key cytokines upregulated in the inflamed mucosa.
Laura D. Manzanares-Meza +10 more
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BMC Biology, 2022 Background Gasdermins are ancient (>500million-years-ago) proteins, constituting a family of pore-forming proteins that allow the release of intracellular content including proinflammatory cytokines.
Diego Angosto-Bazarra +5 more
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Gasdermin D activity in inflammation and host defense [PDF]
Science Immunology, 2019 This Review summarizes our current understanding of the functions of gasdermin D.
Judy Lieberman +2 more
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