Results 21 to 30 of about 13,480,567 (279)

Pharmacological Inhibition of Gasdermin D Suppresses Angiotensin II-Induced Experimental Abdominal Aortic Aneurysms

Biomolecules, 2023
Background: Gasdermin D, a molecule downstream of the nucleotide-binding oligomerization domain-like receptor family pyrin domain containing inflammasome, forms the membrane pore for the secretion of interleukin (IL)-1β and IL-18, and also mediates ...
Jia Guo, Jinyun Shi, Min Qin, Yan Wang, Zhidong Li, Takahiro Shoji, Toru Ikezoe, Yingbin Ge, Baohui Xu   +8 more
doaj   +2 more sources

Mechanism of membrane pore formation by human gasdermin-D

The EMBO Journal, 2018
Gasdermin-D (GSDMD), a member of the gasdermin protein family, mediates pyroptosis in human and murine cells. Cleaved by inflammatory caspases, GSDMD inserts its N-terminal domain (GSDMD; Nterm; ) into cellular membranes and assembles large oligomeric ...
Pfreundschuh, Moritz, Müller, Daniel J., Hiller, Sebastian, Moritz Pfreundschuh, Estefania Mulvihill, Daniel J Müller, Mulvihill, Estefania, Mari, Stefania A., Lorenzo Sborgi, Stefania A Mari, Sborgi, Lorenzo, Sebastian Hiller   +11 more
core   +6 more sources

Indirect regulation of HMGB1 release by gasdermin D [PDF]

Nature Communications, 2020
HMGB1 is an inflammatory mediator released by a variety of cell types. Here, the authors show that unlike IL-1β, HMGB1 is released non-specifically following cell lysis.
Allen Volchuk, Anna Ye, Leon Chi, Benjamin E. Steinberg, Neil M. Goldenberg   +4 more
doaj   +3 more sources

Cigarette smoke-induced gasdermin D activation in bronchoalveolar macrophages and bronchial epithelial cells dependently on NLRP3

Frontiers in Immunology, 2022
Chronic pulmonary inflammation and chronic obstructive pulmonary disease (COPD) are major health issues largely due to air pollution and cigarette smoke (CS) exposure.
Sarah Huot-Marchand, Mégane Nascimento, Elodie Culerier, Mélissa Bourenane, Florence Savigny, Corinne Panek, Cindy Serdjebi, Marc Le Bert, Valérie F. J. Quesniaux, Bernhard Ryffel, Petr Broz, Nicolas Riteau, Aurélie Gombault, Isabelle Couillin   +13 more
doaj   +2 more sources

Viral sensing by epithelial cells involves PKR- and caspase-3-dependent generation of gasdermin E pores [PDF]

iScience, 2023
Summary: Viral sensing in myeloid cells involves inflammasome activation leading to gasdermin pore formation, cytokine release, and cell death. However, less is known about viral sensing in barrier epithelial cells, which are critical to the innate ...
Coralie Guy, Marcin Baran, Pau Ribó-Molina, Bernadette G. van den Hoogen, Andrew G. Bowie   +4 more
doaj   +2 more sources

Caspase-1 initiates apoptosis in the absence of gasdermin D [PDF]

Nature Communications, 2019
In inflammasomes, caspase-1 activation leads to pyroptosis mediated by gasdermin D, but cells lacking gasdermin-D still initiate caspase-dependent cell death. Here, Tsuchiya et al. show that these cells undergo Bid- and caspase-3-dependent apoptosis.
Kohsuke Tsuchiya, Shinsuke Nakajima, Shoko Hosojima, Dinh Thi Nguyen, Tsuyoshi Hattori, Thuong Manh Le, Osamu Hori, Mamunur Rashid Mahib, Yoshifumi Yamaguchi, Masayuki Miura, Takeshi Kinoshita, Hiroko Kushiyama, Mayumi Sakurai, Toshihiko Shiroishi, Takashi Suda   +14 more
doaj   +3 more sources

Investigation of the effect of serum gasdermin d levels on clinical course and mortality in patients with covid-19 [PDF]

BMC Infectious Diseases
Background Cytokine storm is among the pathogenetic mechanisms in patients with severe Coronavirus Disease 2019 (COVID-19). Pyroptosis, a form of programmed cell death, is thought to play an important role in cytokine storms.
Merve Turker Isik, Kubra Demir Onder, Yesim Cekin   +2 more
doaj   +2 more sources

Gasdermin D-mediated pyroptosis: mechanisms, diseases, and inhibitors

Frontiers in Immunology, 2023
Gasdermin D (GSDMD)-mediated pyroptosis and downstream inflammation are important self-protection mechanisms against stimuli and infections. Hosts can defend against intracellular bacterial infections by inducing cell pyroptosis, which triggers the ...
Zhen Dai, Wan-Cong Liu, Xiao-Yi Chen, Xiao Wang, Jun-Long Li, Xiang Zhang   +5 more
doaj   +3 more sources

Evolutionary analyses of the gasdermin family suggest conserved roles in infection response despite loss of pore-forming functionality

BMC Biology, 2022
Background Gasdermins are ancient (>500million-years-ago) proteins, constituting a family of pore-forming proteins that allow the release of intracellular content including proinflammatory cytokines.
Diego Angosto-Bazarra, Cristina Alarcón-Vila, Laura Hurtado-Navarro, María C. Baños, Jack Rivers-Auty, Pablo Pelegrín   +5 more
doaj   +2 more sources

Gasdermin: A new player to the inflammasome game

Biomedical Journal, 2017
Pyroptosis is a lytic type of programmed cell death that was traditionally associated with the involvement of inflammatory caspases, such as caspase-1. These inflammatory caspases are activated within multi-protein complexes called inflammasomes that are
Erivan S. Ramos-Junior, Ana Carolina Morandini   +1 more
doaj   +2 more sources