E3 ubiquitin ligase SYVN1 is a key positive regulator for GSDMD-mediated pyroptosis
Cell Death and Disease, 2022 Gasdermin D (GSDMD) participates in the activation of inflammasomes and pyroptosis. Meanwhile, ubiquitination strictly regulates inflammatory responses. However, how ubiquitination regulates Gasdermin D activity is not well understood.
Yuhua Shi +8 more
doaj +1 more source
Autophagy May Allow a Cell to Forbear Pyroptosis When Confronted With Cytosol-Invasive Bacteria
Frontiers in Immunology, 2022 Inflammatory caspases detect cytosol-invasive Gram-negative bacteria by monitoring for the presence of LPS in the cytosol. This should provide defense against the cytosol-invasive Burkholderia and Shigella species by lysing the infected cell via ...
Carissa K. Harvest +6 more
doaj +1 more source
Genes and Diseases, 2023 Inflammatory bowel disease (IBD) is a chronic relapsing gastrointestinal disorder, while the treatment effect is not satisfactory. Immune responsive gene 1 (IRG1) is a highly expressed gene in macrophage in response to inflammatory response and catalyzes
Wenchang Yang +8 more
doaj +1 more source
Gasdermin D is the only Gasdermin that provides protection against acute Salmonella gut infection in mice [PDF]
Proceedings of the National Academy of Sciences, 2023 Gasdermins (GSDMs) share a common functional domain structure and are best known for their capacity to form membrane pores. These pores are hallmarks of a specific form of cell death called pyroptosis and mediate the secretion of pro-inflammatory cytokines such as interleukin 1β (IL1β) and interleukin 18 (IL18). Thereby, Gasdermins
Fattinger, Stefan A. +16 more
openaire +7 more sources
‘Hints’ in the killer protein gasdermin D: unveiling the secrets of gasdermins driving cell death [PDF]
Cell Death & Differentiation, 2017 Pyroptosis is a lytic form of cell death distinguished from apoptosis, ferroptosis, necrosis, necroptosis, NETosis, oncosis, pyronecrosis and autophagy. Proinflammatory caspases cleave a gasdermin D (GSDMD) protein to generate a 31 kDa N-terminal domain.
Qiu, Shiqiao, Liu, Jing, Xing, Feiyue
openaire +2 more sources
Gasdermin D activity in inflammation and host defense [PDF]
Science Immunology, 2019 This Review summarizes our current understanding of the functions of gasdermin D.
Judy Lieberman +2 more
openaire +2 more sources
Pyroptosis, inflammasome, and gasdermins in tumor immunity
Innate Immunity, 2023 The gasdermins (GSDM), a family of pore-forming proteins, consist of gasdermin A (GSDMA), gasdermin B (GSDMB), gasdermin C (GSDMC), gasdermin D (GSDMD), gasdermin E (GSDME) and DFNB59 (Pejvakin (PJVK)) in humans.
Xiaohu Ouyang +5 more
doaj +1 more source
Mapping the Binding Interactions between Human Gasdermin D and Human Caspase-1 Using Carbene Footprinting [PDF]
, 2023 Carbene footprinting is a recently developed mass spectrometry-based chemical labeling technique that probes protein interactions and conformation. Here, we use the methodology to investigate binding interactions between the protease human Caspase-1 ...
Lloyd, James R. +5 more
core +1 more source
IL-36γ is secreted through an unconventional pathway using the Gasdermin D and P2X7R membrane pores
Frontiers in Immunology, 2022 Mucosal innate immunity functions as the first line of defense against invading pathogens. Members of the IL-1 family are key cytokines upregulated in the inflamed mucosa.
Laura D. Manzanares-Meza +10 more
doaj +1 more source
Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis
, 2020 Inflammasome-activated caspase-1 cleaves gasdermin D to unmask its pore-forming activity, the predominant consequence of which is pyroptosis. Here, we report an additional biological role for gasdermin D in limiting cytosolic DNA surveillance.
Sarkar, Saumendra N. +11 more
core +1 more source