Results 41 to 50 of about 15,764 (222)
Frontiers in Immunology, 2022 Chronic pulmonary inflammation and chronic obstructive pulmonary disease (COPD) are major health issues largely due to air pollution and cigarette smoke (CS) exposure.
Sarah Huot-Marchand +13 more
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Apelin-13 promotes expression of pyroptosis related protein in aortic cells in diabetic mice through eNOS/NO pathway [PDF]
Jichu yixue yu linchuang, 2020 Objective To observe the effects and mechanisms of Apelin-13 on expression of pyroptosis related proteins in aorta of diabetic mice. Methods C57/BL mice of eight weeks old were used as control group;kkAy mice of eight weeks old were used as type 2 ...
WANG Yang-jia, ZHANG Jia, LI Bin, ZENG Xiang-jun
doaj
Etoposide Treatment of Cancer Cell Lines Results in Nuclear Localisation of Cleaved Gasdermin D
European Journal of BiologyObjective: Overcoming resistance to apoptosis is one of the main goals of cancer treatment. Subversion of apoptosis to pyroptosis, an inflammatory cell death mediated by Gasdermin family members, was previously proposed as an alternative strategy for ...
Soukaina Imlilss +3 more
doaj +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Advanced Science, EarlyView.This work proposes a novel strategy to fabricate unimolecular pyroptosis photoinitiators activated by deep‐red light at low light doses. It relies on a photosensitization mechanism to trigger nitric oxide (NO) release from benzisothiadiazole‐based N‐nitrosanilines without modification of nitro moieties, thereby boosting pyroptosis‐mediated ...
Chuangxin Zhang +4 more
wiley +1 more source
Supramolecular Assembly of Stepped‐Persistent ROS Nanogenerator for Sustained Tumor Immunotherapy
Advanced Science, EarlyView.ROS catalytic systems often fail to achieve both effective tumor elimination and persistent immune activation due to their monotonous ROS production profiles. A stepped‐persistent ROS nanogenerator was developed by supramolecularly assembling multiple ROS generation modules within a nanofiber structure to simultaneously extend ROS generation duration ...
Zhenqiang Wang +10 more
wiley +1 more source
Vascular Biology, 2022 Atherosclerosis is characterised by abnormal lipid and cell accumulation within arterial layers that leads to disturbed blood flow. Modified cholesterol forms such as oxidised low-density lipoprotein (oxLDL) enter cells altering their phenotype ...
Majid Almansouri +3 more
doaj +1 more source
Nature Communications, 2019 Gasdermins mediate lytic cell death by forming pores in the plasma membrane. Here the authors show that gasdermins also permeabilize mitochondrial membrane, thereby facilitating intrinsic apoptosis pathway, downstream of apoptotic (Gasdermin E) and ...
Corey Rogers +5 more
doaj +1 more source
The Role of Gasdermin-D-Mediated Pyroptosis in Organ Injury and Its Therapeutic Implications
Organogenesis, 2023 Gasdermin-D (GSDMD) belongs to the Gasdermin family (GSDM), which are pore-forming effector proteins that facilitate inflammatory cell death, also known as pyroptosis.
Joud Mulla +2 more
doaj +1 more source
Gasdermin D Flashes an Exit Signal for IL-1 [PDF]
Immunity, 2018 The IL-1 family of cytokines follows an unconventional pathway of secretion mostly associated with inflammatory cell death. In this issue of Immunity, (Evavold et al., 2017) report gasdermin D pores as channels for active IL-1 release in live phagocytic cells.
Teneema, Kuriakose +1 more
openaire +2 more sources