Results 61 to 70 of about 15,764 (222)
Advanced Science, EarlyView.MG1@NM‐Px serves as a microglia‐targeted STING‐degrading nanoplatform for subarachnoid hemorrhage. Following systemic administration, it crosses the blood–brain barrier and accumulates in activated microglia. STP1‐mediated STING ubiquitination and degradation suppress MAPK/inflammasome signaling, GSDME‐mediated pyroptosis, and IL‐1β release, revealing ...
Ruotian Zhang +13 more
wiley +1 more source
Angewandte Chemie, EarlyView.The engineered DTSe‐based photosensitizer, DZTSe, emerges as an avant‐garde molecular entity, which can distribute to both the endoplasmic reticulum and mitochondria to concurrently trigger pyroptosis and activate the cGAS‐STING pathway. This dual‐action strategy effectively reprograms the tumor microenvironment, enabling potent eradication of primary ...
Cheng Zhang +7 more
wiley +2 more sources
Pyroptosis: a double-edged sword in lung cancer and other respiratory diseases
Cell Communication and SignalingPyroptosis is an active cell death process mediated by gasdermin family proteins including Gasdermin A (GSDMA), Gasdermin B (GSDMB), Gasdermin C (GSDMC), Gasdermin D (GSDMD), Gasdermin E (GSDME, DFNA5), and DFNB59.
Xiao Liang +4 more
doaj +1 more source
BiologyHidradenitis suppurativa (HS) is a debilitating inflammatory skin condition with unclear underlying mechanisms. Recent studies suggest pyroptosis, a highly inflammatory form of programmed cell death, could significantly contribute to the disease process.
Kinga Tyczyńska +7 more
doaj +1 more source
Advanced Science, EarlyView.The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt +16 more
wiley +1 more source
Clinical, Cosmetic and Investigational Dentistry, 2023 Zina Ali Daily,1 Batool Hassan Al-Ghurabi,2 Ahmed Makki A Al-Qarakhli,3 Hashim Mueen Hussein4 1Department of Periodontics, College of Dentistry, University of Baghdad, Baghdad, Iraq; 2Department of Basic Science, College of Dentistry, University of ...
Ali Daily Z +3 more
doaj
The gasdermin-D pore: Executor of pyroptotic cell death
Oncotarget, 2016 Pyroptosis is a lytic type of programmed cell death that is initiated in response to pathogenor host-derived perturbations of the cytosol. It is characterized by cell swelling, lysis, and the release of cytoplasmic content; thus restricting the replication of intracellular pathogens and attracting effector cells of the immune system.
Rühl, Sebastian, Broz, Petr
openaire +4 more sources
Rewiring Pyroptosis to Potentiate Cancer Immunotherapy via a Gasdermin D Agonist Bypassing Caspase‐3
Advanced Science, EarlyView.This work introduces a small‐molecule agonist, DIBDO, that bypasses Casp‐3 to directly trigger GSDMD‐mediated pyroptosis in tumors. Activated by glutathione, DIBDO generates singlet oxygen and molecular iodine, blocking Casp‐3 pathways and inducing immunogenic cell death.
Dan Zhao +6 more
wiley +1 more source
Advanced Science, EarlyView.A supramolecular pyroptotic thermal switch encapsulates I3− within β‐cyclodextrin (β‐CD) and undergoes CaCO3 mineralization. Upon lysosomal acidification, CaCO3 is degraded, releasing Ca2+ and I3−. Concurrently, BODIPY activation converts I3− into I2, inducing oxidative stress and Ca2+ overload, which together trigger caspase‐3/GSDME‐mediated ...
Dan Wu +8 more
wiley +1 more source
Gasdermin: A new player to the inflammasome game
Biomedical Journal, 2017 Pyroptosis is a lytic type of programmed cell death that was traditionally associated with the involvement of inflammatory caspases, such as caspase-1. These inflammatory caspases are activated within multi-protein complexes called inflammasomes that are
Erivan S. Ramos-Junior +1 more
doaj +1 more source