Results 61 to 70 of about 13,480,567 (279)

Unconventional protein secretion by gasdermin pores

, 2023
Unconventional protein secretion (UPS) allows the release of specific leaderless proteins independently of the classical endoplasmic reticulum (ER)-Golgi secretory pathway.
Broz, P., Petr Broz
core   +1 more source

Gasdermin D Deficiency Limits the Transition of Atherosclerotic Plaques to an Inflammatory Phenotype in ApoE Knock-Out Mice

Biomedicines, 2022
Gasdermin D (GSDMD) is the key executor of pyroptotic cell death. Recent studies suggest that GSDMD-mediated pyroptosis is involved in atherosclerotic plaque destabilization. We report that cleaved GSDMD is expressed in macrophage- and smooth muscle cell-
Pauline Puylaert, Melissa Van Praet, Frederik Vaes, Cédric H. G. Neutel, Lynn Roth, Pieter-Jan Guns, Guido R. Y. De Meyer, Wim Martinet   +7 more
doaj   +1 more source

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

, 2015
Intracellular lipopolysaccharide from Gram-negative bacteria including Escherichia coli, Salmonella typhimurium, Shigella flexneri, and Burkholderia thailandensis activates mouse caspase-11, causing pyroptotic cell death, interleukin-1b processing, and ...
O'Rourke, Karen, Irma B. Stowe, Scott J. Snipas, Juan Zhang, Salvesen, Guy, Peter S. Liu, Liu, Peter, Fitzgerald, Linda, Zhang, Juan, Benjamin Haley, Yafei Zhang, Warming, Søren, Lucy X. Morris, Kummerfeld, Sarah, Keith Anderson, Goodnow, Christopher, Wu, Jiansheng, Edward M. Bertram, Jennie R. Lill, Karen O’Rourke, Li, Hong, Haley, Benjamin, Sarah Kummerfeld, Bettina L. Lee, Anderson, Keith, Vishva M. Dixit, Jiansheng Wu, Phung, Qui, Zhang, Yafei, Merone Roose-Girma, Kayagaki, Nobuhiko, Trinna Cuellar, Dixit, Vishva, Søren Warming, Lee, Bettina, Christopher C. Goodnow, Lill, Jennie, Wyne P. Lee, Bertram, Edward, Lee, Wyne, Guy S. Salvesen, Roose-Girma, Merone, Cuellar, Trinna, Morris, Lucy, Hong Li, Snipas, Scott, Qui T. Phung, Stowe, Irma, Nobuhiko Kayagaki, Linda Fitzgerald   +49 more
core   +1 more source

Apelin-13 promotes expression of pyroptosis related protein in aortic cells in diabetic mice through eNOS/NO pathway [PDF]

Jichu yixue yu linchuang, 2020
Objective To observe the effects and mechanisms of Apelin-13 on expression of pyroptosis related proteins in aorta of diabetic mice. Methods C57/BL mice of eight weeks old were used as control group;kkAy mice of eight weeks old were used as type 2 ...
WANG Yang-jia, ZHANG Jia, LI Bin, ZENG Xiang-jun
doaj  

Gasdermin E 매개 칼슘 이온이 세포고사 엑소좀 생합성에 미치는 영향

, 2023
MasterⅠ. 서론 1 Ⅱ. 재료 및 방법 9 A. 세포, 항체 9 B. PCR and In-fusion 클로닝 9 C. Lentiviral vector 형질주입 10 D. CRISPR / Cas9 녹아웃 10 E. PiggyBac transposon system 11 F. 웨스턴 블롯 12 G. Calcium fluorescence luminometer 13 H.
강, 대욱
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

Title Page Circulating Neutrophil Extracellular Traps Promote Gasdermin-D Dependent Lung Injury in Sickle Cell Disease

, 2022
Sickle Cell Disease (SCD) is a monogenic disorder caused by the homozygosity of the beta-S (βs) allele of the β-globin gene, which results in generation of mutant hemoglobin (HbS). Intra-erythrocytic polymerization of mutant hemoglobin promotes hemolysis,
Vats, Ravi
core  

Gasdermin D (GSDMD) as a new target for the treatment of infection [PDF]

MedChemComm, 2019
Inhibition of pyroptosis through targeting the activation or pore-formation of GSDMD.
Ankit Pandeya, Lan Li, Zhenyu Li, Yinan Wei   +3 more
openaire   +2 more sources

Targeting NSUN2‐Mediated m5C Modification Attenuates Chondrocyte Senescence and NLRP3 Activation in Osteoarthritis

Advanced Science, EarlyView.
NSUN2‐mediated m5C modification cooperates with ALYREF to stabilize and export IP3R3 mRNA, increasing IP3R3 expression and Ca2 + overload in chondrocytes. This signaling promotes mitochondrial dysfunction, NLRP3 inflammasome activation, and senescence, thereby accelerating osteoarthritis progression.
Guping Mao, Wei Li, Zhencan Lin, Zengfa Deng, Ming Li, Zongrui Jiang, Changzhao Li, Dianbo Long, Yan Kang   +8 more
wiley   +1 more source