Results 81 to 90 of about 13,480,567 (279)

Synchronized Imaging of Hydrogen Peroxide and Hydroxyl Radical in Pyroptosis and Epilepsy

Advanced Science, EarlyView.
A dual‐responsive fluorescent probe, HH, enables synchronized visualization of H2O2 and •OH through spectrally resolved green and red channels. By tracking redox dynamics in pyroptosis and epilepsy models, HH reveals ROS elevation during seizure‐like pathology and supports evaluation of antioxidant and antiepileptic therapeutic interventions.
Yabing Gan, Yuling Xu, Ting Yu, Yang Li, Xin Jiang, Haoyu Jin, Haitao Li, Youyu Zhang, Peng Yin, Jong Seung Kim   +9 more
wiley   +1 more source

Pyroptosis: a double-edged sword in lung cancer and other respiratory diseases

Cell Communication and Signaling
Pyroptosis is an active cell death process mediated by gasdermin family proteins including Gasdermin A (GSDMA), Gasdermin B (GSDMB), Gasdermin C (GSDMC), Gasdermin D (GSDMD), Gasdermin E (GSDME, DFNA5), and DFNB59.
Xiao Liang, Ya Qin, Dan Wu, Qiong Wang, Hongshuai Wu   +4 more
doaj   +1 more source

Gasdermin-Mediated Pyroptosis in Hidradenitis Suppurativa: Molecular Insights and Therapeutic Implications

Biology
Hidradenitis suppurativa (HS) is a debilitating inflammatory skin condition with unclear underlying mechanisms. Recent studies suggest pyroptosis, a highly inflammatory form of programmed cell death, could significantly contribute to the disease process.
Kinga Tyczyńska, Piotr K. Krajewski, Aleksandra Sójka, Danuta Nowicka-Suszko, Iwona Bednarz-Misa, Mariusz Fleszar, Małgorzata Krzystek-Korpacka, Jacek C. Szepietowski   +7 more
doaj   +1 more source

Engineering a 660 nm‐Responsive Optogenetic Inducer of Pyroptosis for Precision Cancer Therapy

Advanced Science, EarlyView.
This study reports a bioorthogonal pyroptosis inducer, PyroRACS. By using a red‐light‐responsive Cre‐On genetic switch to control the expression of highly cytotoxic GSDMDNT, PyroRACS enables the artificial induction of pyroptosis with precise spatiotemporal control.
Mengkai Zhang, Zhichao Li, Yonghao Ma, Yangyang Sun, Wei Chen, Weiren Huang   +5 more
wiley   +1 more source

ALDH Inhibition‐Primed Photocatalysis Disrupts Cancer Stemness Plasticity

Angewandte Chemie, EarlyView.
DE‐Et converts ALDH‐mediated redox buffering into a photoredox vulnerability by coupling ALDH inhibition with red‐light‐driven catalytic NADH oxidation. This enzyme‐coupled photoredox strategy sustains mitochondrial NADH/NAD+ imbalance, induces pyroptotic tumor cell death, suppresses tumor growth in vivo, and promotes systemic antitumor immunity ...
Yujin Kim, Shankun Yao, Ji Hyeon Kim, Rongrong Huang, Hyeonji Rha, Shumeng Li, Kippeum Lee, Yunjie Xu, Xiaogang Liu, Yuncong Chen, Jong Seung Kim   +10 more
wiley   +2 more sources

Gasdermin D: Evidence of pyroptosis in spontaneous preterm labor with sterile intraâ amniotic inflammation or intraâ amniotic infection

, 2019
ProblemPyroptosis, inflammatory programmed cell death, is initiated through the inflammasome and relies on the poreâ forming actions of the effector molecule gasdermin D.
Gomez‐lopez, Nardhy, Adi L. Tarca, Tarca, Adi L., George Schwenkel, Miller, Derek, Schwenkel, George, Pacora, Percy, Hsu, Chaur‐dong, Hassan, Sonia S., Gudicha, Dereje W., Eunjung Jung, Chaur‐Dong Hsu, Romero, Roberto, Nardhy Gomez‐Lopez, Derek Miller, Sonia S. Hassan, Percy Pacora, Jung, Eunjung, Roberto Romero, Panaitescu, Bogdan, Dereje W. Gudicha, Bogdan Panaitescu   +21 more
core   +1 more source

The gasdermin-D pore: Executor of pyroptotic cell death

Oncotarget, 2016
Pyroptosis is a lytic type of programmed cell death that is initiated in response to pathogenor host-derived perturbations of the cytosol. It is characterized by cell swelling, lysis, and the release of cytoplasmic content; thus restricting the replication of intracellular pathogens and attracting effector cells of the immune system.
Rühl, Sebastian, Broz, Petr
openaire   +4 more sources

A High‐Loading Zn Single‐Atom Nanozyme Targets the Zn/HIF‐1α/GLUT1 Axis to Disrupt Glucose Metabolic Reprogramming and Remodel the Tumor Immune Microenvironment

Advanced Science, EarlyView.
A high‐loading Zn single‐atom nanozyme (ZMG@CS) delivers ML‐SA5 and GOx to lysosomes. ML‐SA5 activates TRPML1 to release endogenous Zn2+, while the nanozyme provides exogenous Zn2+ and GOx‐driven acidification amplifies ROS production. Together, these effects suppress the HIF‐1α/GLUT1 axis, disrupt glucose and redox homeostasis, induce disulfidptosis ...
Zhenxin Wang, Yuhang Tang, Ronghao Yue, Jingtao Xu, Yong Tao, Jie Chen, Shipeng Li, Guosheng Zhao, Jinfang Xue, Mingwei Sun, Fenglei Gao, Yunsheng Ou, Yang Wang   +12 more
wiley   +1 more source

Gasdermin and Its Role in Pyroptosis

, 2022
The gasdermin family (GSDMs) contains a group of uncharacterized proteins that form membrane pores and serve as a major substrate for inflammatory caspases and the execution of pyroptosis, which is recognized as a novel type of programmed cell death [1].
Kasianenko, O. (Oksana), Mingcheng, L. (Liu)   +1 more
core  

Lanthanum Carbonate Nanosheets Based Colloidal Hydrogel for Modulating Innate & Adaptive Tumor Immunotherapy by Augmented Cellular Pyroptosis

Advanced Science, EarlyView.
The Gela/decitabine/La2(CO3)3 colloidal (GDLC) hydrogel developed here could reverse the epigenetic silencing of the GSDME gene by the synergistic interaction between DAC and La3+, while concurrently activating caspase‐3, thus facilitating pyroptosis induction under the tumor microenvironment.
Yang Hong, Haitao Wu, Weitao Wang, Xuan Zhang, Qian Chen, Yaoyu Hu, Zhengbao Zha   +6 more
wiley   +1 more source