Results 101 to 110 of about 13,480,567 (279)

Supplementary Data for 'Vastly different energy landscapes of the membrane insertions of monomeric gasdermin D and A3'

Simulation files, molecular structures and trajectories, and jupyter notebooks used for analysis underlaying our publication on membrane insertion of monomeric gasdermin D to E. coli polar lipid extract (PLE). In detail: charmm36-july2017.ff simulation
Korn, Viktoria Helena, Pluhackova, Kristyna   +1 more
core   +1 more source

Interleukin‐1α Mediates Pancreatic Fibroblast Activation, Regulates Immune Cell Recruitment and Fibrosis in Acute and Chronic Pancreatitis

Advanced Science, EarlyView.
During pancreatitis, IL‐1α is released from necrotic acinar cells. In response to IL‐1α, pancreatic fibroblasts release chemokines and cytokines that regulate the recruitment of immune cells to the damaged organ. Furthermore, IL‐1α primes fibroblasts, resulting in increased tissue fibrosis during chronic pancreatitis.
Hala Mazloum, Shenja Buchholz, Hanna Schifter, Sabine Ameling, Leif Steil, Ben Lewin Becker, Elke Hammer, Georg Homuth, Uwe Völker, Barbara M. Bröker, Lukas Zierke, Frank Ulrich Weiss, Juliane Glaubitz, Matthias Sendler   +13 more
wiley   +1 more source

Targeting the NLRP3 Inflammasome-Gasdermin D Axis to Combat Cardiovascular Diseases

Cardiovascular disease remains a leading global cause of mortality, with inflammation playing a crucial role in driving its pathology. Despite advancements in cardiovascular disease management, current treatment options primarily address risk factors and
Choi, JS, Vince, JE, de Haan, JB, Sharma, A, Pervin, M   +4 more
core   +1 more source

Inhibition of caspase-1 or gasdermin-D enable caspase-8 activation in the Naip5/NLRC4/ASC inflammasome.

, 2017
Legionella pneumophila is a Gram-negative, flagellated bacterium that survives in phagocytes and causes Legionnaires' disease. Upon infection of mammalian macrophages, cytosolic flagellin triggers the activation of Naip/NLRC4 inflammasome, which ...
Marcelo S F Pereira, Graziele Z Manin, Larissa D. Cunha, Dario S Zamboni, Fernanda V. S. Castanheira, Dario S. Zamboni, Danielle P A Mascarenhas, Fernanda V S Castanheira, Daiane M. Cerqueira, Marcelo S. F. Pereira, Graziele Z. Manin, Danielle P. A. Mascarenhas, Larissa D Cunha, Talita D. Fernandes, Talita D Fernandes, Daiane M Cerqueira   +15 more
core   +1 more source

Beyond Biomimetics: Pathology‐Informed Engineering Rescues Reconstituted HDL From Inflammatory Dysfunction for Sepsis Immunotherapy

Advanced Science, EarlyView.
A pathology‐informed engineering strategy rescues reconstituted HDL from inflammatory dysfunction in sepsis. By integrating a ceria nanozyme‐celastrol coordination complex, the platform preserves HDL structure and endotoxin handling, sustains hierarchical intracellular delivery, and enhances immunoregulation across pathological models, translating ...
Han Zhou, Lei Zhang, Xingyu Cai, Jiajia Su, Guangyu Dai, Xue Chen, Hanming Wang, Jia Hua, Jianping Liu, Chunmeng Sun, Xiancheng Chen, Erhao Wang, Wenli Zhang   +12 more
wiley   +1 more source

Gasdermin D-independent IL-1ß secretion by living human monocytic cells

, 2018
Interleukin-1β (IL-1β), a major pro-inflammatory cytokine, is a leaderless cytosolic protein whose secretion does not follow the classical endoplasmic reticulum-to-Golgi pathway, and for which the mechanism of secretion remains to be established.
Six, Charlotte
core  

A Brief Discussion of Gasdermin D\u27s Function in Multiple Sclerosis

, 2022
Multiple Sclerosis (MS) is a neurodegenerative disease that particularly affects the nerves of the central nervous system (CNS). MS results in the degradation of the myelin sheath surrounding the axon, which is crucial for effective transmission of nerve
Brint, Amie
core  

Gasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death

Cell Reports, 2018
Summary: Gasdermin D (GSDMD) is considered a proinflammatory factor that mediates pyroptosis in macrophages to protect hosts from intracellular bacteria.
Hiroto Kambara, Fei Liu, Xiaoyu Zhang, Peng Liu, Besnik Bajrami, Yan Teng, Li Zhao, Shiyi Zhou, Hongbo Yu, Weidong Zhou, Leslie E. Silberstein, Tao Cheng, Mingzhe Han, Yuanfu Xu, Hongbo R. Luo   +14 more
doaj   +1 more source

Early endosome autoantigen 1 regulates IL-1β release upon caspase-1 activation independently of gasdermin D membrane permeabilization

, 2019
International audienceUnconventional protein secretion represents an important process of the inflammatory response. The release of the pro-inflammatory cytokine interleukin (IL)-1β which burst during pyroptosis as a consequence of gasdermin D plasma ...
Couillin, Isabelle, Martín-Sánchez, Fátima, Tapia-Abellán, Ana, Compan, Vincent, Pelegrin, Pablo, Baroja-Mazo, Alberto   +5 more
core   +1 more source

Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus

Animal Research and One Health, EarlyView.
Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu, Aosi Qi, Shuyu Zhong, Haozhen Du, Shimeng Guo, Hongsheng Ouyang, Hongming Yuan, Daxin Pang, Zicong Xie   +8 more
wiley   +1 more source