Results 121 to 130 of about 13,480,567 (279)

Effect of Gasdermin D on Pyroptosis in Mouse Macrophages

, 2018
Gasdermin D (GSDMD) is a protein encoded by the GSDMD gene and is found in the epithelial tissue and immune cells of humans. GSDMD is known to be cleaved into two segments, the pore forming domain on the N-terminal and the repressor domain on the C ...
O'Shea, Colleen E
core   +3 more sources

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

The killer protein Gasdermin D [PDF]

Cell Death & Differentiation, 2016
John A Wright, Clare E Bryant
openaire   +1 more source

Multiple sclerosis: the NLRP3 inflammasome, gasdermin D, and therapeutics

Annals of Translational Medicine
Multiple sclerosis (MS) stands as a chronic inflammatory disease characterized by its neurodegenerative impacts on the central nervous system. The complexity of MS and the significant challenges it poses to patients have made the exploration of effective treatments a crucial area of research.
Brint, Amie, Greene, Seth, Fennig-Victor, Alyssa R., Wang, Shanzhi   +3 more
openaire   +2 more sources

Quercetin‐zinc coordination polymer coated CaCO3 nanoparticles potentiate radiotherapy through reprogramming tumor immunosuppression

BMEMat, EarlyView.
Synthesis of QZCaCO3‐PEG to synergistically enhance the immunogenicity of radiotherapy through concurrent Zn2+‐induced cancer cell pyroptosis and Que‐mediated hypoxia amelioration through sequentially suppressing TGF‐β secretion and ECM deposition. Abstract Radiotherapy has demonstrated broad applications in treating solid tumors, but the hostile tumor
Chunjie Wang, Hengze Ding, Yu Hao, Honglin An, Ziliang Dong, Minming Chen, Yujie Zhu, Quguang Li, Bin Huang, Liangzhu Feng   +9 more
wiley   +1 more source

Nanomedicine‐driven innovations in postoperative cancer immunotherapy: Remodeling tumor microenvironment and precision delivery strategies

BMEMat, EarlyView.
Nanomedicine‐Driven Strategies for Suppressing Postoperative Tumor Recurrence. This schematic illustrates three pivotal nanomedical strategies that synergistically counteract recurrence by targeting residual disease and the immunosuppressive tumor microenvironment within the surgical cavity.
Lisong Pang, Zhuomin Wang, Zhenhua Jin, Ahmed H. Ghonaim, Hengcheng Zhang, Xinyu You, Jinzhuo Ning, Jiaqing Cao, Yang Liu   +8 more
wiley   +1 more source

Gasdermin-D and Caspase-7 are the key Caspase-1/8 substrates downstream of the NAIP5/NLRC4 inflammasome required for restriction of Legionella pneumophila

, 2019
Inflammasomes are cytosolic multi-protein complexes that detect infection or cellular damage and activate the Caspase-1 (CASP1) protease. The NAIP5/NLRC4 inflammasome detects bacterial flagellin and is essential for resistance to the flagellated ...
Eduard Ansaldo (6894428), Shally R Margolis, Isabella Rauch, Nichols, Randilea D, Russell E. Vance (229811), Danielle P A Mascarenhas, Randilea D Nichols, Gonçalves, Augusto V, Quirino, Gustavo FS, Eduard Ansaldo, Ansaldo, Eduard, Fontana, Mary F, Vance, Russell E, Rauch, Isabella, Gustavo F S Quirino, Danielle P. A. Mascarenhas (4329526), Shally R. Margolis (6894419), Dario S Zamboni, Margolis, Shally R, Isabella Rauch (423753), Mary F. Fontana (229800), Augusto V. Gonçalves (6894416), Dario S. Zamboni (192409), Gustavo F. S. Quirino (6894422), Augusto V Gonçalves, Russell E Vance, Zamboni, Dario S, Randilea D. Nichols (6894425), Mascarenhas, Danielle PA, Mary F Fontana   +29 more
core   +1 more source

Heat stress in spermatogenesis: a redox‐dependent decision network linking ROS, autophagy, and regulated cell death

Biological Reviews, EarlyView.
ABSTRACT Heat stress (HS) is an increasing threat to male reproductive health, disrupting spermatogenesis through complex and interdependent cellular responses within the seminiferous epithelium. Although excessive reactive oxygen species (ROS) production is a hallmark of HS, ROS also act as central regulators of cell fate decisions beyond their role ...
Ribrio Ivan Tavares Pereira Batista
wiley   +1 more source

Gasdermin D-mediated neutrophil pyroptosis drives inflammation in psoriasis. [PDF]

Elife
Abstract Psoriasis is a multifactorial immune-mediated inflammatory disease. Its pathogenesis involves abnormal accumulation of neutrophils and T-cell related abnormalities. Pyroptosis is a type of regulated cell death associated with innate immunity, but its role in psoriasis is unclear. In this study, we found that gasdermin D (Gsdmd)
Liu J, Jiang Y, Diao Z, Chen D, Xia R, Wang B, Yang S, Yin Z.   +7 more
europepmc   +4 more sources

Crosstalk Between Parkinson's Disease and Colorectal Cancer: Genetic Mechanisms, Gut Microbiota, and Therapeutic Insights

Health Care Science, EarlyView.
This review elucidates the crosstalk between Parkinson's disease and colorectal cancer, driven by shared genetics (PRKN, PINK1, DJ‐1) involving oxidative stress, cell cycle regulation, and inflammation. It identifies the gut microbiota—via functional amyloids and short‐chain fatty acids (SCFAs)—as a mechanistic bridge, offering insights for dual ...
Jiacheng Ying, Zhengyuan Fang, Cheng Zhang, Xu Liu, Jianzhi Cui, Zezhi Li, Jiayin Tang   +6 more
wiley   +1 more source