Results 131 to 140 of about 15,764 (222)

Gasdermin D antagonizes immunosuppression in prostate cancer by inducing LAMC2 degradation to block M2 macrophage polarization. [PDF]

J Immunother Cancer
Du Q, Han Z, Zhang Y, Li Y, Sun A, Wang B, Chen Y, Wang X.   +7 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, Volume 16, Issue 8, Page 1563-1592, August 2026.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Pyroptosis-mediator Gasdermin D in serum: a potential biomarker in diabetic kidney disease. [PDF]

Front Endocrinol (Lausanne)
Ding N, Wei C, Liu Q, Liu X, Huo L, Yu F, Yang C.   +6 more
europepmc   +1 more source

Camouflage Protein‐Engineered Extracellular Vesicles Alleviate TMJ‐OA by Hijacking Caspase‐1 to Suppress Pyroptosis

Journal of Extracellular Vesicles, Volume 15, Issue 8, August 2026.
ABSTRACT Temporomandibular joint osteoarthritis (TMJ‐OA) is highly prevalent with an insidious onset. Severe inflammation and significant degenerative changes are often associated with the condition, and current clinical treatments remain inadequate. In this study, we focus on pyroptosis and engineered the camouflage protein (GSDMD‐C) attached to the ...
Yufei Liu, Jie Zhou, Yukang Wang, Zhihui Hu, Guimin Yin, Mengsen Zhu, Jianke Huo, Chenyang Zhang, Yiming Wang, Shuang Fu, Jinpeng Wan, Jie Wang, Lanju Xu, Zhiling Zhang, Shufang Wang   +14 more
wiley   +1 more source

Knockdown of Gasdermin D protects hippocampal neurons by regulating both pyroptosis and ferroptosis in a rat model of status epilepticus. [PDF]

Acta Epileptol
Feng F, Wang H, Tian Y, Luo R, Cai Q.
europepmc   +1 more source

The Dual Role of the Gut Microbiota in Cancer Chemoresistance

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Comparison between Microbiota and Cancer therapy. ABSTRACT Chemoresistance is one of the primary reasons that cancer chemotherapy fails to deliver successful treatment outcomes and contributes to poor overall survival rates for patients with cancer. New research has begun to shed light on the effects of the gut microbiome (GM).
Hamed Tahmasebi, Aisa Bahar, Meisam Khazaei, Mohammad Reza Arabestani   +3 more
wiley   +1 more source

d-amino acids restrain macrophage IL-1β release through gasdermin D acetylation. [PDF]

Sci Adv
Wu Z, Hu Q, Shen Y, Fu J, Liu B, Zhang M, Hung I, Liu C, Ren W.   +8 more
europepmc   +1 more source

The Role of Inflammation and Immunity in Cardiovascular Disease: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
Inflammation in cardiovascular disease is a dynamic and context‐dependent network rather than a secondary response to injury. Mitochondrial danger signaling links metabolic stress to immune activation through TLR priming, NLRP3 inflammasome amplification, cGAS–STING signaling, and immunometabolic gating, providing a basis for more precise therapeutic ...
Jiaxiang Rong, Zhen Wang, Xiaoxiao Lin, Ziwen Lei, Qianqian Huang, Hang Liu, Fei Luan, Junbo Zou, Yajun Shi   +8 more
wiley   +1 more source

Pathogenesis of Tuberculosis: Interplay Between Host Antituberculosis Immunity and Immune Evasion Strategies of Mycobacterium Tuberculosis

MedComm, Volume 7, Issue 8, August 2026.
Mycobacterium tuberculosis–host interactions and infection outcomes. Following initial infection, alveolar macrophages phagocytose the pathogen, prompting the recruitment of innate immune cells including neutrophils, NK cells, and interstitial macrophages.
Xiaojuan Zhang, Ying Liu, Yilin Hou, Hongxia Niu   +3 more
wiley   +1 more source

Inhibition of gasdermin D attenuates neutrophil extracellular trap formation induced by platelet-derived exosome in necrotizing enterocolitis. [PDF]

Cell Commun Signal
Zhang Y, Gao K, Ye C, Deng Q, Xinzhong, Ma Y, Guo C.   +6 more
europepmc   +1 more source