Results 151 to 160 of about 15,764 (222)

Emestrin-Type Epidithiodiketopiperazines Inhibited Gasdermin D-Mediated Pyroptosis via Caspase-3/7 Activation. [PDF]

MedComm (2020)
Geng B, Lin S, Yim WY, Sun W, Zhang X, Ma C, Zhang Z, Guo Q, Gao J, Zeng H, Tong Q, Wang Y, Fan Z, Hou J, Li M, Zhang Y, Hu Z.   +16 more
europepmc   +1 more source

Therapeutic intervention with sinomenine and irisin to preserve cardiac function after ischaemia–reperfusion injury

Experimental Physiology, Volume 111, Issue 8, Page 3557-3569, 1 August 2026.
Abstract Despite advancements in reperfusion therapy, myocardial ischaemia–reperfusion (IR) injury remains a major clinical challenge. This study investigated whether a novel dual‐target pre‐conditioning strategy using sinomenine and irisin could enhance myocardial resistance against IR injury. Ninety male Sprague–Dawley rats were utilized.
Lianjun Wu, Sining Bi, Amany Belal, Zhuzhu Liu   +3 more
wiley   +1 more source

Correction to "Gasdermin D mutation protects against renal ischemia reperfusion injury". [PDF]

Physiol Rep
europepmc   +1 more source

NEDD4L-mediated Gasdermin D and E ubiquitination regulates cell death and tissue injury. [PDF]

Cell Death Differ
Shah SS, Manning JA, Lim Y, Sinha D, Murthy AMV, Ganesan R, Robinson N, Alnemri ES, Masters SL, Vince JE, Kumar S.   +10 more
europepmc   +1 more source

GASDERMIN D-mediated pyroptosis as a therapeutic target in TAU-dependent frontotemporal dementia mouse model. [PDF]

J Biomed Sci
Silva-Llanes I, Smith LA, Abdelkader-Guillén A, Jiménez-Villegas J, Sarrió D, Moreno-Bueno G, Lastres-Becker I.   +6 more
europepmc   +1 more source

Gasdermin D pores hitch a ride: extracellular vesicles spread pyroptosis. [PDF]

Cell Res
Du G, Wu H.
europepmc   +1 more source

NLRP3 inflammasome activation in astrocytes restricts SARS-CoV-2 through gasdermin-D-driven IL-1β release. [PDF]

Front Immunol
de Farias IS, Duarte-Barbosa M, Salazar N, Andreata-Santos R, de Lucena VWL, Maricato JT, Gazzinelli RT, Janini LMR, Bortoluci KR.   +8 more
europepmc   +1 more source

Improved structure of mouse gasdermin D: a new blueprint for structure-based drug design. [PDF]

Acta Crystallogr F Struct Biol Commun
De Colibus L, Ludzia P, Biasutto A, Pica A, Hopper JTS, Jazayeri A, Dürr KL.   +6 more
europepmc   +1 more source

Cleavage of cellular substrate porcine gasdermin D by porcine torovirus 3C-like protease induces pyroptosis. [PDF]

Virulence
Pan D, Liu XE, Hong X, Liu Y, Yin PF, Zeng JW, Lv Q, Du EZ, Fan W, Yang YL, Shi F, Wang B, Dong B, Huang YW.   +13 more
europepmc   +1 more source

Gasdermin D Cleavage and Cytokine Release, Indicative of Pyroptotic Cell Death, Induced by Ophiobolin A in Breast Cancer Cell Lines. [PDF]

Int J Mol Sci
Ranganathan S, Ojo T, Subramanian A, Tobin J, Kornienko A, Boari A, Evidente A, Benton ML, Romo D, Taube JH.   +9 more
europepmc   +1 more source