Results 31 to 40 of about 15,764 (222)

Pyroptosis and degenerative diseases of the elderly

Cell Death and Disease, 2023
Pyroptosis is a recently described mechanism of programmed cell death mediated by proteins of the gasdermin family. Widely recognized signaling cascades include the classical, non-classical, caspase-3-dependent gasdermin E and caspase-8-dependent ...
Jiamin Zhou, Jingjing Qiu, Yuwan Song, Tiantian Liang, Sha Liu, Chao Ren, Xicheng Song, Limei Cui, Yan Sun   +8 more
doaj   +1 more source

Pyroptosis inhibiting nanobodies block Gasdermin D pore formation

Nature Communications, 2023
Human Gasdermin D (GSDMD) is a key mediator of pyroptosis, a pro-inflammatory form of cell death occurring downstream of inflammasome activation as part of the innate immune defence.
Anja Kopp, Gregor Hagelueken, Isabell Jamitzky, Jonas Moecking, Lisa D. J. Schiffelers, Florian I. Schmidt, Matthias Geyer   +6 more
doaj   +1 more source

Circulating Gasdermin-D in Critically Ill Patients

Critical Care Explorations, 2019
The key to further improving outcomes in sepsis lies in understanding and abrogating the dysfunctional immune response that leads to organ failure. Activation of gasdermin-D, a pore-forming protein within the inflammasome cascade, has recently been recognized as the critical step in pyroptosis and organ dysfunction.
Homsy, Elie, Das, Srabani, Consiglio, Paul, McAtee, Corynn, Zachman, Angela, Nagaraja, Haikady, Wewers, Mark D., Exline, Matthew C., Mallampalli, Rama K., Sarkar, Anasuya   +9 more
openaire   +2 more sources

Molecular mechanisms of gasdermin D pore-forming activity

Nature Immunology, 2023
The regulated disruption of the plasma membrane, which can promote cell death, cytokine secretion or both is central to organismal health. The protein gasdermin D (GSDMD) is a key player in this process. GSDMD forms membrane pores that can promote cytolysis and the release of interleukin-1 family cytokines into the extracellular space.
Pascal Devant, Jonathan C. Kagan
openaire   +2 more sources

The Role of Pyroptosis in Alzheimer's Disease

Journal of Integrative Neuroscience, 2023
Pyroptosis is a type of regulated cell death that relies on caspases, vesicles, and the cleavage of gasdermin proteins (which create pores in the cell membrane).
Yanxiu Ju, Ling Zhao, Songtao Li, Qing Zhao   +3 more
doaj   +1 more source

Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D‐derived peptide inhibitor

The FASEB Journal, 2019
The inflammasomes are signaling platforms that promote the activation of inflammatory caspases such as caspases‐1/4/5/11. Recent studies identified gasdermin D (GSDMD) as an effector for pyroptosis downstream of the inflammasome signaling pathways. Cleavage of GSDMD by inflammatory caspases allows its N‐terminal domain to associate
JIE YANG, Zhonghua Liu, Chuanping Wang, Rui Yang, Joseph K. Rathkey, Wuxian Shi, Yinghua Chen, George R. Dubyak, Derek W. Abbott, Tsan Sam Xiao   +9 more
openaire   +1 more source

Succination inactivates gasdermin D and blocks pyroptosis

Science, 2020
Fumarate targets pyroptosis A form of inflammatory cell death called pyroptosis depends on the caspase-mediated cleavage of gasdermin D (GSDMD), the fragments of which assemble into permeability pores that then kill the cell. The mechanisms regulating this important cellular process are not yet fully understood. Humphries
Fiachra Humphries, Liraz Shmuel-Galia, Natalia Ketelut-Carneiro, Sheng Li, Bingwei Wang, Venkatesh V. Nemmara, Ruth Wilson, Zhaozhao Jiang, Farnaz Khalighinejad, Khaja Muneeruddin, Scott A. Shaffer, Ranjan Dutta, Carolina Ionete, Scott Pesiridis, Shuo Yang, Paul R. Thompson, Katherine A. Fitzgerald   +16 more
openaire   +4 more sources

Gasdermin D: A Potential New Auxiliary Pan-Biomarker for the Detection and Diagnosis of Diseases

Biomolecules, 2023
Pyroptosis is a form of programmed cell death mediated by gasdermins, particularly gasdermin D (GSDMD), which is widely expressed in tissues throughout the body.
Ningyi Wan, Jing Shi, Jianguo Xu, Juan Huang, Delu Gan, Min Tang, Xiaohan Li, Ying Huang, Pu Li   +8 more
doaj   +1 more source

Gasdermin D Deficiency Limits the Transition of Atherosclerotic Plaques to an Inflammatory Phenotype in ApoE Knock-Out Mice

Biomedicines, 2022
Gasdermin D (GSDMD) is the key executor of pyroptotic cell death. Recent studies suggest that GSDMD-mediated pyroptosis is involved in atherosclerotic plaque destabilization. We report that cleaved GSDMD is expressed in macrophage- and smooth muscle cell-
Pauline Puylaert, Melissa Van Praet, Frederik Vaes, Cédric H. G. Neutel, Lynn Roth, Pieter-Jan Guns, Guido R. Y. De Meyer, Wim Martinet   +7 more
doaj   +1 more source

Pharmacological Inhibition of Gasdermin D Suppresses Angiotensin II-Induced Experimental Abdominal Aortic Aneurysms

Biomolecules, 2023
Background: Gasdermin D, a molecule downstream of the nucleotide-binding oligomerization domain-like receptor family pyrin domain containing inflammasome, forms the membrane pore for the secretion of interleukin (IL)-1β and IL-18, and also mediates ...
Jia Guo, Jinyun Shi, Min Qin, Yan Wang, Zhidong Li, Takahiro Shoji, Toru Ikezoe, Yingbin Ge, Baohui Xu   +8 more
doaj   +1 more source