Results 31 to 40 of about 13,480,567 (279)

Targeting gasdermin D and neutrophil mobilization for cardioprotection

Metabolism Open, 2021
Maria Dalamaga, Junli Liu
doaj   +4 more sources

Gasdermin D: A New Inflammatory Biomarker in Assessing Clinical Disease Activity in Crohn’s Disease [PDF]

The Turkish Journal of Gastroenterology
Background/Aims: Crohn’s disease (CD) is an inflammatory, progressive disorder requiring monitoring of treatment response and disease course. Gasdermin D (GSDMD), a protein belonging to the gasdermin protein family, plays a role in inflammatory cell ...
Osman Cagin Buldukoglu, Serkan Ocal, Galip Egemen Atar, Besir Kaya, Muhammet Devran Isik, Gul Aydin Tigli, Serdar Akca, Ferda Akbay Harmandar, Yesim Cekin, Ayhan Hilmi Cekin   +9 more
doaj   +2 more sources

Rewiring Pyroptosis to Potentiate Cancer Immunotherapy via a Gasdermin D Agonist Bypassing Caspase-3. [PDF]

Adv Sci (Weinh)
This work introduces a small‐molecule agonist, DIBDO, that bypasses Casp‐3 to directly trigger GSDMD‐mediated pyroptosis in tumors. Activated by glutathione, DIBDO generates singlet oxygen and molecular iodine, blocking Casp‐3 pathways and inducing immunogenic cell death.
Zhao D, Zhang L, Wen Y, Cheng L, Tian S, Meng F, Luo L.   +6 more
europepmc   +2 more sources

Gasdermin D cysteine residues synergistically control its palmitoylation-mediated membrane targeting and assembly [PDF]

The EMBO Journal
Gasdermin D (GSDMD) executes the cell death program of pyroptosis by assembling into oligomers that permeabilize the plasma membrane. Here, by single-molecule imaging, we elucidate the yet unclear mechanism of Gasdermin D pore assembly and the role of ...
Eleonora Margheritis, Shirin Kappelhoff, John Danial, Nadine Gehle, Wladislaw Kohl, Rainer Kurre, Ayelén González Montoro, Katia Cosentino   +7 more
doaj   +9 more sources

Cyclodextrin attenuates atherosclerosis by diminishing gasdermin D (GSDMD)-mediated pyroptosis [PDF]

Scientific Reports
Pyroptosis, a programmed form of cell death, typically increases during the atherosclerosis development. Cyclodextrins are oligosaccharides with anti-atherosclerotic properties.
Mohammad Ismail Hajary Sagor, Qiuran Wang, Junshu Wang, Guili Lian, Yan Yan, Huibin Tang, Gufeng Gao, Huakan Lin, Liangdi Xie   +8 more
doaj   +2 more sources

Gasdermin D: A potential mediator and prognostic marker of bladder cancer

Frontiers in Molecular Biosciences, 2022
Background: Bladder cancer is considered one of the commonest widespread cancers, its presentation ranges from non-muscle invasive form to being muscle-invasive. The gasdermin family of proteins consists of six proteins.
Randa El-Gamal, Randa El-Gamal, Mona Abdelrahim, Mohamed El-Sherbiny, Eman T. Enan, Mohammad El-Nablaway, Mohammad El-Nablaway   +6 more
doaj   +1 more source

Gasdermin D and Beyond – Gasdermin-mediated Pyroptosis in Bacterial Infections

Journal of Molecular Biology, 2022
The discovery of pyroptosis and its subsequent implications in infection and immunity has uncovered a new angle of host-defence against pathogen assault. At its most simple, gasdermin-mediated pyroptosis in bacterial infection would be expected to remove pathogens from the relative safety of the cytosol or pathogen containing vacuole/phagosome whilst ...
Lee M, Booty, Clare E, Bryant
openaire   +2 more sources

The Roles of Gasdermin D in Coronavirus Infection and Evasion [PDF]

Frontiers in Microbiology, 2021
Pyroptosis is lytic, programmed cell death and plays a critical role against microbial invasion, functioning as an innate immune effector mechanism. The pore-forming protein gasdermin D (GSDMD), a member of gasdermin family proteins, is a primary effector of pyroptosis.
Xiang Liu, Shihao Ding, Pinghuang Liu
openaire   +3 more sources

Caspase-11-Gasdermin D-Mediated Pyroptosis Is Involved in the Pathogenesis of Atherosclerosis

Frontiers in Pharmacology, 2021
Background: Pyroptosis is a form of cell death triggered by proinflammatory signals. Recent studies have reported that oxidized phospholipids function as caspase-11 agonists to induce noncanonical inflammasome activation in immune cells. As the levels of
Mengqing Jiang, Xuejing Sun, Suzhen Liu, Yan Tang, Yunming Shi, Yuanyuan Bai, Yujie Wang, Qiong Yang, Qize Yang, Weihong Jiang, Hong Yuan, Qixia Jiang, Jingjing Cai, Jingjing Cai   +13 more
doaj   +1 more source

Gasdermin-D activation promotes NLRP3 activation and host resistance to Leishmania infection

Nature Communications, 2023
Here, de Sá et al. show that Gasdermin-D is transiently activated in Leishmania-infected macrophages and promotes NLRP3 inflammasome activation, but not cell death.
Keyla S. G. de Sá, Luana A. Amaral, Tamara S. Rodrigues, Adriene Y. Ishimoto, Warrison A. C. de Andrade, Leticia de Almeida, Felipe Freitas-Castro, Sabrina S. Batah, Sergio C. Oliveira, Mônica T. Pastorello, Alexandre T. Fabro, Dario S. Zamboni   +11 more
doaj   +1 more source