Results 1 to 10 of about 422,774 (309)

Apoptosis and Pharmacological Therapies for Targeting Thereof for Cancer Therapeutics

Sci, 2022
Apoptosis is an evolutionarily conserved sequential process of cell death to maintain a homeostatic balance between cell formation and cell death. It is a vital process for normal eukaryotic development as it contributes to the renewal of cells and ...
Vishakha Singh, Amit Khurana, Umashanker Navik, Prince Allawadhi, Kala Kumar Bharani, Ralf Weiskirchen   +5 more
doaj   +1 more source

Interferon-Induced Protein 6-16 (IFI6-16) from Litopenaeus vannamei Regulate Antiviral Immunity via Apoptosis-Related Genes

Viruses, 2022
A growing number of evidence shows that some invertebrates possess an antiviral immunity parallel to the interferon (IFN) system of higher vertebrates.
Kai Lǚ, Haoyang Li, Sheng Wang, Anxing Li, Shaoping Weng, Jianguo He, Chaozheng Li   +6 more
doaj   +1 more source

Identification and Functional Analysis of Apoptotic Protease Activating Factor-1 (Apaf-1) from Spodoptera litura

Insects, 2021
Apoptotic protease activating factor-1 (Apaf-1) is an adaptor molecule, essential for activating initiator caspase and downstream effector caspases, which directly cause apoptosis.
Haihao Ma, Xiumei Yan, Lin Yan, Jingyan Zhao, Jiping Song, Rong Peng, Yongbo Yang, Jianxin Peng, Kaiyu Liu   +8 more
doaj   +1 more source

Caspase-2: the orphan caspase [PDF]

Cell Death & Differentiation, 2011
Despite an abundance of literature on the role of caspase-2 in apoptosis, there exists much controversy about this protease making it difficult to place caspase-2 correctly in the apoptotic cascade, and hence its role in apoptosis remains unclear. The identification of the PIDDosome as a signaling platform for caspase-2 activation prompted intense ...
L, Bouchier-Hayes, D R, Green
openaire   +2 more sources

ER Stress in COVID-19 and Parkinson’s Disease: In Vitro and In Silico Evidences

Brain Sciences, 2022
The outbreak of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) signifies a serious worldwide concern to public health. Both transcriptome and proteome of SARS-CoV-2-infected cells synergize the progression of infection in
Zahara L. Chaudhry, Mahmoud Gamal, Ingrid Ferhati, Mohamad Warda, Bushra Y. Ahmed   +4 more
doaj   +1 more source

Antimicrobial Peptide Brevinin-1RL1 from Frog Skin Secretion Induces Apoptosis and Necrosis of Tumor Cells

Molecules, 2021
Cancer has always been one of the most common malignant diseases in the world. Therefore, there is an urgent need to find potent agents with selective antitumor activity against cancer cells.
Xiaoman Ju, Dongmei Fan, Lingmei Kong, Qihong Yang, Yiying Zhu, Shaohua Zhang, Guifeng Su, Yan Li   +7 more
doaj   +1 more source

Structural Characterization and Anticancer Activity of a New Anthraquinone from Senna velutina (Fabaceae)

Pharmaceuticals, 2023
In this study, a novel compound was isolated, identified, and its chemical structure was determined from the extract of the roots of Senna velutina.
David Tsuyoshi Hiramatsu Castro, Daniel Ferreira Leite, Debora da Silva Baldivia, Helder Freitas dos Santos, Sikiru Olaitan Balogun, Denise Brentan da Silva, Carlos Alexandre Carollo, Kely de Picoli Souza, Edson Lucas dos Santos   +8 more
doaj   +1 more source

Spontaneous poisoning by Cestrum intermedium in dairy cattle

Pesquisa Veterinária Brasileira, 2021
: Acute hepatotoxicity caused by plants poisoning is responsible for economic losses in farm animals in Brazil. Reports of Cestrum intermedium natural poisoning in cattle are not commonly described in Rio Grande do Sul (RS).
Camila B. Pohl, Márcia E. Hammerschmitt, Franciéli A. Molossi, Marina P. Lorenzett, Ronaldo M. Bianchi, Márcia Vignoli-Silva, Samuel Bianchetti, Welden Panziera, Claudio S.L. Barros, Saulo P. Pavarini, David Driemeier   +10 more
doaj   +1 more source

Caspase-3 western blot.

, 2022
Western blot of pro- and cleaved caspase-3 [ratio to ß-actin]. Shown are representative blots separated by location of lung tissue sampling (contusion site, ipsilateral control, and contralateral control). Lung tissue samples were homogenized, separated,
Martin Sassen (14232410), Bernd Schmeck (334625), Hans-Helge Müller (158349), Thorsten Steinfeldt (9870476), Hinnerk Wulf (745052), Kerstin Seidel (385253), Wilhelm Bertrams (3172785), Marc-Alexander Oestreich (13961375)   +7 more
core   +1 more source

Regulation of caspase-3 processing by cIAP2 controls the switch between pro-inflammatory activation and cell death in microglia. [PDF]

, 2014
The activation of microglia, resident immune cells of the central nervous system, and inflammation-mediated neurotoxicity are typical features of neurodegenerative diseases, for example, Alzheimer's and Parkinson's diseases. An unexpected role of caspase-
Rodhe, J, Venero, JL, Rodhe, J,, Rodhe, Johanna, Joseph, B, Burguillos García, Miguel Ángel, Venero Recio, José Luis, Kavanagh, E, Burguillos, MA, Kavanagh, Edel T., Joseph, Bertrand, Joseph, B,   +11 more
core   +1 more source