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Identification of a new caspase homologue: caspase-14 [PDF]
Cell Death and Differentiation, 1998 Caspases are cysteinyl aspartate-specific proteinases, many of which play a central role in apoptosis. Here, we report the identification of a new murine caspase homologue, viz. caspase-14. It is most related to human/murine caspase-2 and human caspase-9, possesses all the typical amino acid residues of the caspases involved in catalysis, including the
Peter Vandenabeele +2 more
exaly +3 more sources
, 2022 Western blot of pro- and cleaved caspase-3 [ratio to ß-actin]. Shown are representative blots separated by location of lung tissue sampling (contusion site, ipsilateral control, and contralateral control). Lung tissue samples were homogenized, separated,
Martin Sassen (14232410) +7 more
core +1 more source
Apoptosis and Pharmacological Therapies for Targeting Thereof for Cancer Therapeutics
Sci, 2022 Apoptosis is an evolutionarily conserved sequential process of cell death to maintain a homeostatic balance between cell formation and cell death. It is a vital process for normal eukaryotic development as it contributes to the renewal of cells and ...
Vishakha Singh +5 more
doaj +1 more source
Viruses, 2022 A growing number of evidence shows that some invertebrates possess an antiviral immunity parallel to the interferon (IFN) system of higher vertebrates.
Kai Lǚ +6 more
doaj +1 more source
Insects, 2021 Apoptotic protease activating factor-1 (Apaf-1) is an adaptor molecule, essential for activating initiator caspase and downstream effector caspases, which directly cause apoptosis.
Haihao Ma +8 more
doaj +1 more source
ER Stress in COVID-19 and Parkinson’s Disease: In Vitro and In Silico Evidences
Brain Sciences, 2022 The outbreak of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) signifies a serious worldwide concern to public health. Both transcriptome and proteome of SARS-CoV-2-infected cells synergize the progression of infection in
Zahara L. Chaudhry +4 more
doaj +1 more source
Caspase-2: the orphan caspase [PDF]
Cell Death & Differentiation, 2011 Despite an abundance of literature on the role of caspase-2 in apoptosis, there exists much controversy about this protease making it difficult to place caspase-2 correctly in the apoptotic cascade, and hence its role in apoptosis remains unclear. The identification of the PIDDosome as a signaling platform for caspase-2 activation prompted intense ...
L, Bouchier-Hayes, D R, Green
openaire +2 more sources
Caspase-2S relative mRNA expression levels in neurological disease. [PDF]
, 2022 (A) Caspase-2S mRNA expression levels trend lower in AD but not MCI compared to CN controls. Caspase-2S mRNA do not differ in LBD (B) or HD (C) compared to controls.
Ronald C. Petersen (9562700) +5 more
core +1 more source
Paradoxical roles of caspase-3 in regulating cell survival, proliferation, and tumorigenesis
Journal of Cell Biology, 2022 Eskandari and Eaves review evidence of caspase-3-regulated protein quality, proliferation, differentiation, and tumorigenic activity in viable cells.
E. Eskandari, C. Eaves
semanticscholar +1 more source
Molecules, 2021 Cancer has always been one of the most common malignant diseases in the world. Therefore, there is an urgent need to find potent agents with selective antitumor activity against cancer cells.
Xiaoman Ju +7 more
doaj +1 more source