Results 1 to 10 of about 125,259 (249)

Rickettsia heilongjiangensis suppresses RIPK1 kinase-mediated host cell death during the infection

Infection and Immunity
Spotted fever group Rickettsia (SFGR) poses a significant challenge in the field of tick-borne diseases, characterized by its obligate intracellular lifestyle and its ability to disrupt various host cellular pathways. A deeper understanding of Rickettsia’
Maozhang He, Qingyin Shi, Yu Xin, Shurui Zheng, Yan Liu, Kehan Xu   +5 more
doaj   +1 more source

The NLRP3 Inflammasome Is Upregulated in HIV-Infected Antiretroviral Therapy-Treated Individuals with Defective Immune Recovery

Frontiers in Immunology, 2018
BackgroundInflammasome-mediated activation of caspase-1 regulates inflammatory responses and pyroptosis. We analyzed possible associations between inflammasome-related genes and immune reconstitution in HIV-infected antiretroviral therapy (ART)-treated ...
Alessandra Bandera, Michela Masetti, Michela Masetti, Massimiliano Fabbiani, Mara Biasin, Antonio Muscatello, Nicola Squillace, Mario Clerici, Mario Clerici, Andrea Gori, Andrea Gori, Daria Trabattoni   +11 more
doaj   +1 more source

Executioner caspase is proximal to Fasciclin 3 which facilitates non-lethal activation in Drosophila olfactory receptor neurons

eLife
The nervous system undergoes functional modification independent of cell turnover. Caspase participates in reversible neuronal modulation via non-lethal activation. However, the mechanism that enables non-lethal activation remains unclear.
Masaya Muramoto, Nozomi Hanawa, Misako Okumura, Takahiro Chihara, Masayuki Miura, Natsuki Shinoda   +5 more
doaj   +1 more source

Preparation and Evaluation of Diosmin-Loaded Diphenylcarbonate-Cross-Linked Cyclodextrin Nanosponges for Breast Cancer Therapy

Pharmaceuticals, 2022
In the current study, diosmin (DSM)-loaded beta-cyclodextrin (β-CD)-based nanosponges (NSPs) using diphenylcarbonate (DPC) as a cross-linker were prepared.
Md. Khalid Anwer, Mohammed Muqtader Ahmed, Mohammed F. Aldawsari, Muzaffar Iqbal, Vinay Kumar   +4 more
doaj   +1 more source

Discovery of Novel 1,2,4-Oxadiazole Derivatives as Potent Caspase-3 Activator for Cancer Treatment

Chemistry, 2021
In the present study, a quantitative structure–activity relationship (QSAR) and docking studies were accomplished on a series of 1,2,4-oxadiazoles. The results of QSARs are reliable and have high predictive ability for both the internal (q2 = 0.610) and ...
Ankur Vaidya
doaj   +1 more source

Gene Expression Profiling of Apoptotic Proteins in Circulating Peripheral Blood Mononuclear Cells in Type II Diabetes Mellitus and Modulation by Metformin

Diabetes, Metabolic Syndrome and Obesity, 2021
Mohammed Al Dubayee,1– 3 Awad Alshahrani,1– 3 Dana Aljada,4 Mahmoud Zahra,5 Ahmed Alotaibi,1 Ibrahim Ababtain,1 Malik Alnaim,1 Ali Alahmari,1 Abdullah Aljarallah,1 Muhammad Affan Elahi,5 Hana MA Fakhoury5 1College of Medicine, King Saud Bin ...
Al Dubayee M, Alshahrani A, Aljada D, Zahra M, Alotaibi A, Ababtain I, Alnaim M, Alahmari A, Aljarallah A, Elahi MA, Fakhoury HMA   +10 more
doaj  

Evidence for Sexual Dimorphism in the Response to TLR3 Activation in the Developing Neonatal Mouse Brain: A Pilot Study

Frontiers in Physiology, 2019
Toll-like receptor (TLR)3 activation during the neonatal period produces responses linked to the origins of neuropsychiatric disorders. Although there is sexual dimorphism in neuropsychiatric disorders, it is unknown if brain responses to TLR3 activation
Raul Chavez-Valdez, Amin Mottahedin, Linnea Stridh, Tracylyn R. Yellowhair, Tracylyn R. Yellowhair, Lauren L. Jantzie, Lauren L. Jantzie, Frances J. Northington, Carina Mallard, Carina Mallard   +9 more
doaj   +1 more source

Carnosic Acid Induces Apoptosis and Inhibits Akt/mTOR Signaling in Human Gastric Cancer Cell Lines

Pharmaceuticals, 2021
Gastric cancer is among the most common malignancies worldwide. Due to limited availability of therapeutic options, there is a constant need to find new therapies that could target advanced, recurrent, and metastatic gastric cancer.
Waseem El-Huneidi, Khuloud Bajbouj, Jibran Sualeh Muhammad, Arya Vinod, Jasmin Shafarin, Ghalia Khoder, Mohamed A. Saleh, Jalal Taneera, Eman Abu-Gharbieh   +8 more
doaj   +1 more source

Global analysis of viral infection in an archaeal model system

Frontiers in Microbiology, 2012
The origin and evolutionary relationship of viruses is poorly understood. This makes archaeal virus-host of particular interest because the hosts generally root near the base of phylogenetic trees, while some of the viruses have clear structural ...
Walid S. Maaty, Joseph eSteffens, Joshua eHeinemann, Alice C. Ortmann, Benjamin D. Reeves, Swapan K. Biswas, Edward A. Dratz, Paul A. Grieco, Mark J. Young, Brian eBothner   +9 more
doaj   +1 more source

Pan-caspase inhibition during normothermic machine perfusion of discarded livers mitigates ex situ innate immune responses

Frontiers in Immunology, 2022
Access to liver transplantation is limited by a significant organ shortage. The recent introduction of machine perfusion technology allows surgeons to monitor and assess ex situ liver function prior to transplantation. However, many donated organs are of
Siavash Raigani, Siavash Raigani, John Santiago, Anders Ohman, Megan Heaney, Sofia Baptista, Sofia Baptista, Taylor M. Coe, Reinier J. de Vries, Ivy Rosales, Angela Shih, James F. Markmann, James F. Markmann, Philip Gruppuso, Korkut Uygun, Korkut Uygun, Jennifer Sanders, Heidi Yeh   +17 more
doaj   +1 more source