Results 31 to 40 of about 125,259 (249)
Cell Death & Differentiation, 2000 Caspases, a group of cysteine proteases, constitute the effector arm of the cell death machinery. There are seven caspases known in Drosophila, three of which contain long amino-terminal prodomains. Although, compared to mammalian caspases, much less is known about the biology of Drosophila caspases, many studies have shown that caspases are essential ...
S, Kumar, J, Doumanis
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The regulation of apoptotic cell death
Brazilian Journal of Medical and Biological Research, 1999 Apoptosis is a fundamental biological phenomenon in which the death of a cell is genetically and biochemically regulated. Different molecules are involved in the regulation of the apoptotic process.
Amarante-Mendes G.P., Green D.R.
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Pharmaceuticals, 2023 Gastric cancer is among the major causes of death from neoplasia leading causes of death worldwide, with high incidence rates and problems related to its treatment.
Mirian Letícia Carmo Bastos +12 more
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Oncogene, 2003 Caspases are a family of cysteine proteases that play important roles in regulating apoptosis. A decade of research has generated a wealth of information on the signal transduction pathways mediated by caspases, the distinct functions of individual caspases and the mechanisms by which caspases mediate apoptosis and a variety of physiological and ...
Degterev, Alexei +2 more
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Frontiers in Cellular Neuroscience, 2014 Aminoglycoside-induced cochlear ototoxicity causes hair cell (HC) loss and results in hearing impairment in patients. Previous studies have developed the concept of an ototoxicity-sensitive period during which the cochleae of young mice are more ...
Shan eSun +13 more
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Frontiers in Oncology, 2022 Recent studies suggest that inhibition of the ATR kinase can potentiate radiation-induced antitumor immune responses, but the extent and mechanisms of such responses in human cancers remain scarcely understood.
Adrian Eek Mariampillai +6 more
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Cell Death & Differentiation, 1999 Caspases are the key effector molecules of the physiological death process known as apoptosis, although some are involved in activation of cytokines, rather than cell death. They exist in most of our cells as inactive precursors (zymogens) that kill the cell once activated. Caspases can be controlled in two ways.
P G, Ekert, J, Silke, D L, Vaux
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Neobaicalein, a flavonoid from the Scutellaria litwinowii Bornm. & Sint. ex Bornm. induced apoptosis in human leukemic cell lines [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): Neobaicalein is one of the rich plant flavonoids isolated from the roots of Scutellaria spp. In this study, we evaluated and compared cytotoxic activity and the related apoptosis mechanisms of neobaicalein from Scutellaria litwinowii Bornm.
Seyed Ahmad Emami +6 more
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Animal Cells and Systems, 2019 Certain cancer types, including breast cancer, are accompanied with stiffening of the surrounding extracellular matrix (ECM). Previous studies suggest that this stiffened matrix influences cancer cell progression, such as proliferation and invasion, both
Jieun Lee +8 more
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Induction of ROS-dependent apoptotic cell death by platycodin D in human prostate cancer PC3 cells
Journal of Men's Health, 2022 Background and objective: Platycodin D (PD), a triterpenoid saponin isolated from an edible and medicinal plant Platycodon grandiflorum, possesses multiple pharmacological properties.
Yung Hyun Choi
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