Results 1 to 10 of about 80,424 (267)
Non-Canonical Roles of Apoptotic Caspases in the Nervous System
Frontiers in Cell and Developmental Biology, 2022 Caspases are a family of cysteine proteases that predominantly cleave their substrates after aspartic acid residues. Much of what we know of caspases emerged from investigation a highly conserved form of programmed cell death called apoptosis.
Mahshid H. Dehkordi +2 more
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eLife, 2023 During apoptosis, caspases degrade 8 out of ~30 nucleoporins to irreversibly demolish the nuclear pore complex. However, for poorly understood reasons, caspases are also activated during cell differentiation.
Ukrae H Cho, Martin W Hetzer
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New gold pincer-type complexes induce caspase-dependent apoptosis in human cancer cells in vitro [PDF]
Vojnosanitetski Pregled, 2021 Background/Aim. The use of cisplatin as a chemotherapeutic opened the door to the new metal-based drug research. New complexes containing metals such as platinum, palladium, ruthenium and gold have recently been analyzed as potential antitumor agents ...
Zarić Milan M. +9 more
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Frontiers in Veterinary Science, 2021 Caspases, a family of cysteine protease enzymes, are a critical component of apoptotic cell death, but they are also involved in cellular differentiation.
Wonchul Jung +8 more
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BMC Genomics, 2021 Background Apoptosis is an important process for an organism’s innate immune system to respond to pathogens, while also allowing for cell differentiation and other essential life functions.
Susanne Vogeler +3 more
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Identification and functional characterization of two executioner caspases in Crassostrea gigas. [PDF]
PLoS ONE, 2014 Caspase-3 and caspase-7 are two key effector caspases that play important roles in apoptotic pathways that maintain normal tissue and organ development and homeostasis.
Tao Qu +8 more
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Poultry Science, 2022 : This study investigated the association between serum aspartate aminotransferase activity and apoptotic potentials assessed by the levels of serum parameters, including Ca2+ and serotonin, Ca2+ channel genes, and caspase genes, at the early postmortem.
Boin Lee, Jae Yeong Kim, Young Min Choi
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Pharmaceuticals, 2021 We aimed to characterize the mechanisms involved in neuroprotection by R-PIA administered before pilocarpine-induced seizures. Caspase-1 and caspase-3 activities were assayed using fluorimetry, and cathepsin D, HSP-70, and AKT expression levels were ...
Daniele Suzete Persike +2 more
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Current Oncology, 2023 Although remarkable progress has been made, colorectal cancer remains a significant global health issue. One of the most challenging aspects of cancer treatment is the resistance of tumor cells to classical chemotherapy.
Monica Susan +6 more
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Frontiers in Physiology, 2018 Caspases are well known proteases in the context of inflammation and apoptosis. Recently, novel roles of pro-apoptotic caspases have been reported, including findings related to the development of hard tissues.
Eva Svandova +6 more
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