Results 11 to 20 of about 80,424 (267)
Regulated Cell Death in Fungi, the Role of Metacaspases and Assay Techniques [PDF]
Methods and ProtocolsCaspases orchestrate metazoan apoptosis, regulating processes such as embryogenesis, the death of old and infected cells and immune tolerance. Structural orthologs of caspases have been identified in bacteria, plants, protists and fungi and regulated ...
Derek Wilkinson
doaj +2 more sources
Caspase-2: the orphan caspase [PDF]
Cell Death & Differentiation, 2011 Despite an abundance of literature on the role of caspase-2 in apoptosis, there exists much controversy about this protease making it difficult to place caspase-2 correctly in the apoptotic cascade, and hence its role in apoptosis remains unclear. The identification of the PIDDosome as a signaling platform for caspase-2 activation prompted intense ...
L, Bouchier-Hayes, D R, Green
openaire +2 more sources
eLife, 2017 Apoptosis and its molecular mediators, the caspases, have long been regarded as tumor suppressors and one hallmark of cancer is ‘Evading Apoptosis’.
Ernesto Pérez +2 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2020 Increasing evidence shows that, in addition to the classical function of protein processing and transport, the Golgi apparatus (GA) is also involved in apoptosis, one of the most common forms of cell death.
Qiang He +7 more
doaj +1 more source
Journal of Neuroscience Research, 2002 AbstractThe basic mechanisms that underlie neurodegenerative diseases are unknown. Loss of function of specific regions of the brain is due to incapacitation of cells that constitute those regions. Cells can simply stop functioning normally (neurons may cease to transmit signals), or they may die.
Carol M, Troy, Guy S, Salvesen
openaire +2 more sources
Effector Caspases and Leukemia
International Journal of Cell Biology, 2011 Caspases, a family of aspartate-specific cysteine proteases, play a major role in apoptosis and a variety of physiological and pathological processes.
Ying Lu, Guo-Qiang Chen
doaj +1 more source
Brainiac Caspases: Beyond the Wall of Apoptosis
Frontiers in Cellular Neuroscience, 2019 For the last two decades, caspases, a family of cysteine-aspartic proteases, have evolved from being considered solely as regulators of apoptosis or inflammation to having a wider range of functions.
Ana María Espinosa-Oliva +3 more
doaj +1 more source
Rhamnazin inhibits proliferation and induces apoptosis of human jurkat leukemia cells in vitro [PDF]
The Ukrainian Biochemical Journal, 2015 Antiproliferative and apoptogenic effects of rhamnazin, a dimethoxylated derivative of quercetin, were studied in human acute lymphoblastic leukemia Jurkat cells.
А. А. Philchenkov, М. P. Zavelevych
doaj +1 more source
Caspases and their substrates [PDF]
Cell Death & Differentiation, 2017 Protease biology is intimately linked to the functional consequences of substrate cleavage events. Human caspases are a family of 12 fate-determining cysteine proteases that are best known for driving cell death, either apoptosis or pyroptosis. More recently, caspases have been shown to be involved in other cellular remodeling events as well including ...
Olivier Julien, James A Wells
openaire +2 more sources
Increased Expression of Pyroptosis in Leukocytes of Patients with Kawasaki Disease
Diagnostics, 2021 Background: Kawasaki disease (KD) is a form of febrile vasculitis that primarily occurs in children. It can cause inflammation of the coronary arteries, which leads to aneurysms.
Kuang-Che Kuo +6 more
doaj +1 more source