Results 21 to 30 of about 80,424 (267)
Cell Death & Differentiation, 2000 Caspases, a group of cysteine proteases, constitute the effector arm of the cell death machinery. There are seven caspases known in Drosophila, three of which contain long amino-terminal prodomains. Although, compared to mammalian caspases, much less is known about the biology of Drosophila caspases, many studies have shown that caspases are essential ...
S, Kumar, J, Doumanis
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Microglia: Agents of the CNS Pro-Inflammatory Response
Cells, 2020 The pro-inflammatory immune response driven by microglia is a key contributor to the pathogenesis of several neurodegenerative diseases. Though the research of microglia spans over a century, the last two decades have increased our understanding ...
José A. Rodríguez-Gómez +9 more
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Frontiers in Immunology, 2023 GSDME is the only direct executor of caspase-dependent pyroptosis in both canonical and non-canonical inflammasomes known to date in fish, and plays an important role in anti-bacterial infection and inflammatory response.
Yanjing Zhao +7 more
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Oncogene, 2003 Caspases are a family of cysteine proteases that play important roles in regulating apoptosis. A decade of research has generated a wealth of information on the signal transduction pathways mediated by caspases, the distinct functions of individual caspases and the mechanisms by which caspases mediate apoptosis and a variety of physiological and ...
Degterev, Alexei +2 more
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Inhibitor of apoptosis proteins as E3 ligases for ubiquitin and NEDD8
Biomolecular Concepts, 2013 The inhibitors of apoptosis proteins (IAPs) are endogenous inhibitors for apoptosis. Apoptosis is carried out by caspases, which are the family of cystein proteases. IAPs regulate caspases through two conserved regions, the baculovirus IAP repeats (BIRs)
Kamada Shinji
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mBio, 2022 As a result of the ongoing virus-host arms race, viruses have evolved numerous immune subversion strategies, many of which are aimed at suppressing the production of type I interferons (IFNs).
Tate Tabtieng +4 more
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Cell Death & Differentiation, 1999 Caspases are the key effector molecules of the physiological death process known as apoptosis, although some are involved in activation of cytokines, rather than cell death. They exist in most of our cells as inactive precursors (zymogens) that kill the cell once activated. Caspases can be controlled in two ways.
P G, Ekert, J, Silke, D L, Vaux
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Caspases: An apoptosis mediator
Journal of Advanced Veterinary and Animal Research, 2015 The process of programmed cell death, or apoptosis, is generally characterized by distinct morphological characteristics and energy - dependent biochemical mechanisms.
Tapan Kumar Palai, Smruti Ranjan Mishra
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Mitochondrial control of innate immune signaling by irradiated cancer cells
OncoImmunology, 2020 Type I interferon (IFN) release by irradiated cancer cells is paramount for radiation therapy to elicit anticancer immunity. Our findings demonstrate that mitochondrial outer membrane permeabilization (MOMP) triggered by RT enables exposure of ...
Takahiro Yamazaki, Lorenzo Galluzzi
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Caspases in synaptic plasticity
Molecular Brain, 2012 Caspases are a family of cysteine proteases that play key roles in programmed cell death (apoptosis). Mounting evidence in recent years shows that caspases also have important non-apoptotic functions in multiple cellular processes, such as synaptic ...
Li Zheng, Sheng Morgan
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