Results 31 to 40 of about 90,413 (210)
Sometimes even apoptosis fails: implications for cancer
Molecular & Cellular Oncology, 2020 Apoptosis is vital for the correct morphogenesis of multi-cellular organisms. However, like most physiological programs, the cell’s ability to commit suicide is hijacked by cancer in its own proliferative and invasive interest.
Kevin Berthenet +2 more
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Caspases and Kinases in a Death Grip [PDF]
, 2009 The complex process of apoptosis is orchestrated by caspases, a family of cysteine proteases with unique substrate specificities. Accumulating evidence suggests that cell death pathways are finely tuned by multiple signaling events, including direct ...
Manabu Kurokawa +3 more
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Cell Death & Differentiation, 2006 The relatively common occurrence of sequences within proteins that match the consensus substrate specificity of caspases in intracellular proteins suggests a multitude of substrates in vivo - somewhere in the order of several hundred in humans alone. Indeed, the list of proteins that are reported to be cleaved by caspases in vitro proliferates rapidly.
J C, Timmer, G S, Salvesen
openaire +2 more sources
Applied Sciences, 2021 Datura innoxia is an important species of Solanaceae family with several purposes in folk medicine. This study intends to explore the cytotoxic effect of D. innoxia on various cancer cell proliferation. D.
Mohammed Al-Zharani +9 more
doaj +1 more source
Targeting caspases in intracellular protozoan infections [PDF]
, 2009 Caspases are cysteine aspartases acting either as initiators (caspases 8, 9, and 10) or executioners (caspases 3, 6, and 7) to induce programmed cell death by apoptosis. Parasite infections by certain intracellular protozoans increase host cell life span
Wânia F. Pereira +15 more
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Cell Death & Differentiation, 2011 Evasion of apoptosis is considered to be one of the hallmarks of human cancers. This cell death modality is executed by caspases and several upstream regulatory factors, which direct their proteolytic activity, have been defined as either tumor suppressors or oncogenes.
Olsson, M, Zhivotovsky, B
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Biology, 2023 Aqueous extracts from Posidonia oceanica’s green and brown (beached) leaves and rhizomes were prepared, submitted to phenolic compound and proteomic analysis, and examined for their potential cytotoxic effect on HepG2 liver cancer cells in culture.
Giulia Abruscato +11 more
doaj +1 more source
EVOLUTIONARY AND BIOCHEMICAL CHARACTERIZATION OF EFFECTOR CASPASES [PDF]
, 2021 Caspases are an ancient class of cysteine-dependent aspartate-specific proteases that control apoptosis, responsible for cell differentiation, and maintain cellular homeostasis in multicellular organisms.
Shrestha, Suman
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Role of viruses in oral squamous cell carcinoma
Oncology Reviews, 2012 The etiology of oral squamous cell carcinoma (OSCC) is complex and involves many factors. The most clearly defined risk factors are smoking and alcohol, which substantially increase the risk of oral SCC.
Rashmi Metgud +3 more
doaj +1 more source
Caspases: An apoptosis mediator [PDF]
, 2020 The process of programmed cell death, or apoptosis, is generally characterized by distinct morphological characteristics and energy -dependent biochemical mechanisms.
Mishra/ J Palai, Adv
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