Results 41 to 50 of about 90,413 (210)

The multifaceted activity of insect caspases [PDF]

, 2015
Caspases are frequently considered synonymous with apoptotic cell death. Increasing evidence demonstrates that these proteases may exert their activities in non-apoptotic functions.
MALAGOLI, Davide, Zibaee, A, ACCORSI, ALICE   +2 more
core   +1 more source

Design, Synthesis and Biological Evaluation of Syn and Anti-like Double Warhead Quinolinones Bearing Dihydroxy Naphthalene Moiety as Epidermal Growth Factor Receptor Inhibitors with Potential Apoptotic Antiproliferative Action

Molecules, 2022
Our investigation includes the synthesis of new naphthalene-bis-triazole-bis-quinolin-2(1H)-ones 4a–e and 7a–e via Cu-catalyzed [3 + 2] cycloadditions of 4-azidoquinolin-2(1H)-ones 3a–e with 1,5-/or 1,8-bis(prop-2-yn-1-yloxy)naphthalene (2) or (6).
Essmat M. El-Sheref, Mohamed A. Ameen, Kamal M. El-Shaieb, Fathy F. Abdel-Latif, Asmaa I. Abdel-naser, Alan B. Brown, Stefan Bräse, Hazem M. Fathy, Iqrar Ahmad, Harun Patel, Hesham A. M. Gomaa, Bahaa G. M. Youssif, Asmaa H. Mohamed   +12 more
doaj   +1 more source

Caspase-1 Is an Apical Caspase Leading to Caspase-3 Cleavage in the AIM2 Inflammasome Response, Independent of Caspase-8 [PDF]

Journal of Molecular Biology, 2018
Canonical inflammasomes are multiprotein complexes that can activate both caspase-1 and caspase-8. Caspase-1 drives rapid lysis of cells by pyroptosis and maturation of interleukin (IL)-1β and IL-18. In caspase-1-deficient cells, inflammasome formation still leads to caspase-3 activation and slower apoptotic death, dependent on caspase-8 as an apical ...
Sagulenko, Vitaliya, Vitak, Nazarii, Vajjhala, Parimala, Vince, James E, Stacey, Katryn J   +4 more
openaire   +5 more sources

Caspases disrupt mitochondrial membrane barrier function [PDF]

, 1998
Mitochondrial intermembrane proteins including cytochrome c are known to activate caspases. Accordingly, a disruption of the mitochondrial membrane barrier function with release of cytochrome into the cytosol has been shown to precede caspase activation ...
Naoufal Zamzami, Luigi Ravagnan, Isabel Marzo, Marzo, Isabel, Petit, Patrice X, Susin, Santos A, Catherine Brenner, Santos A Susin, Zamzami, Naoufal, Ravagnan, Luigi, Nathanael Larochette, Larochette, Nathanael, Patrice X Petit, Brenner, Catherine, Guido Kroemer, Kroemer, Guido   +15 more
core   +1 more source

Inhibition of Lung Cancer Proliferation by Wogonin is Associated with Activation of Apoptosis and Generation of Reactive Oxygen Species

Balkan Medical Journal, 2020
Background:Lung cancer has a very high incidence rate and is one of the commonly diagnosed tumors in developed countries.Aims:To investigate the effect of wogonin on A549 and A427 lung cancer cells and explore the mechanism involved.Study Design:Cell ...
Chengyang Wang, Chuangcheng Cui
doaj   +1 more source

Yamogenin-Induced Cell Cycle Arrest, Oxidative Stress, and Apoptosis in Human Ovarian Cancer Cell Line

Molecules, 2022
Steroidal saponins are a group of compounds with complex structures and biological activities. They have anti-inflammatory, antimicrobial, fungicidal, and antitumor properties.
Justyna Stefanowicz-Hajduk, Anna Hering, Magdalena Gucwa, Monika Czerwińska, J. Renata Ochocka   +4 more
doaj   +1 more source

Identification of a new caspase homologue: caspase-14 [PDF]

Cell Death & Differentiation, 1998
Caspases are cysteinyl aspartate-specific proteinases, many of which play a central role in apoptosis. Here, we report the identification of a new murine caspase homologue, viz. caspase-14. It is most related to human/murine caspase-2 and human caspase-9, possesses all the typical amino acid residues of the caspases involved in catalysis, including the
M, Van de Craen, G, Van Loo, S, Pype, W, Van Criekinge, I, Van den brande, F, Molemans, W, Fiers, W, Declercq, P, Vandenabeele   +8 more
openaire   +2 more sources

Oxidative and Non-Oxidative Antimicrobial Activities of the Granzymes

Frontiers in Immunology, 2021
Cell-mediated cytotoxicity is an essential immune defense mechanism to fight against viral, bacterial or parasitic infections. Upon recognition of an infected target cell, killer lymphocytes form an immunological synapse to release the content of their ...
Marilyne Lavergne, Maria Andrea Hernández-Castañeda, Pierre-Yves Mantel, Denis Martinvalet, Denis Martinvalet, Michael Walch   +5 more
doaj   +1 more source

Roles of Bcl-2 and caspase-9 and -3 in CD30-induced human eosinophil apoptosis

Journal of Microbiology, Immunology and Infection, 2017
Background/purpose: Activation of cell surface CD30 by immobilized anti-CD30 monoclonal antibodies (mAb) induces strong apoptosis in human eosinophils.
Hye Jin Lee, Eun-Kyoung Lee, Young Eun Seo, Youn Ho Shin, Hwan Soo Kim, Yoon Hong Chun, Jong-Seo Yoon, Hyun Hee Kim, Man Yong Han, Chang-Keun Kim, Kyu-Earn Kim, Young Yull Koh, Jin Tack Kim   +12 more
doaj   +1 more source

DECAY, a novel Drosophilacaspase related to mammalian caspase-3 and caspase-7. [PDF]

Journal of Biological Chemistry, 1999
Caspases are key effectors of programmed cell death in metazoans. In Drosophila, four caspases have been described so far. Here we describe the identification and characterization of the fifth Drosophila caspase, DECAY. DECAY shares a high degree of homology with the members of the mammalian caspase-3 subfamily, particularly caspase-3 and caspase-7 ...
Dorstyn, L., Read, S., Quinn, L., Richardson, H., Kumar, S.   +4 more
openaire   +3 more sources